期刊
CLINICAL & TRANSLATIONAL ONCOLOGY
卷 21, 期 2, 页码 167-177出版社
SPRINGER INT PUBL AG
DOI: 10.1007/s12094-018-1902-8
关键词
Drug-eluting beads transarterial chemoembolization (DEB-TACE); Efficacy; Safety; Previous cTACE treatment; Liver cancer
类别
资金
- National Nature Science Foundation of China [81371658]
- Zhejiang Provincial Natural Science Foundation of China [LZ18H180001]
PurposeTo assess the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) in liver cancer patients with different times of previous conventional transarterial chemoembolization (cTACE) treatments.Methods367 liver cancer patients about to receive DEB-TACE treatment were enrolled in this prospective cohort study. All patients were divided into no previous cTACE group (NPC group), 1-2 times previous cTACE group (PC group) and triple or above previous cTACE group (TPC group) according to the times of previous cTACE treatments.ResultsThere was no difference in complete response (CR) (P=0.671) and objective response rate (ORR) (P=0.062) among three groups. Additionally, no difference in overall survival (OS) among groups (P=0.899) was found. As to liver function, most liver function indexes were deteriorative at 1week after DEB-TACE operation, but returned to baseline at 1-3months after DEB-TACE operation in all three groups, while percentage of abnormal total bile acid (TBA) patients was higher in TPC group than NPC and PC groups at 1-3month post-DEB-TACE (P=0.018). As for safety profiles, the incidence of pain during DEB-TACE operation was lower in TPC group compared to NPC and PC groups (P=0.005), while no difference of other adverse events was found during and 1month post-DEB-TACE treatment among three groups.ConclusionDEB-TACE treatment was equally efficient and tolerated in liver cancer patients with different times of previous cTACE treatments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据