Article
Cardiac & Cardiovascular Systems
Tim Koldenhof, Isabelle C. Van Gelder, Harry J. G. M. Crijns, Michiel Rienstra, Robert G. Tieleman
Summary: This study aimed to compare the effects of non-dihydropyridine calcium channel blockers and beta-blockers on heart rate in patients with non-permanent atrial fibrillation. The results showed that calcium channel blockers were associated with a lower incidence of bradycardia during sinus rhythm compared to beta-blockers.
Article
Cardiac & Cardiovascular Systems
Maria Hee Jung Park Frausing, Martijn E. Van De Lande, Alexander H. Maass, Bao-Oanh Nguyen, Martin E. W. Hemels, Robert G. Tieleman, Tim Koldenhof, Mirko De Melis, Dominik Linz, Ulrich Schotten, Vanessa Weberndoerfer, Harry J. G. M. Crijns, Isabelle C. Van Gelder, Jens Cosedis Nielsen, Michiel Rienstra
Summary: This study aimed to examine brady- and tachyarrhythmias using continuous rhythm monitoring in patients with paroxysmal self-terminating AF (PAF). The results showed that almost half of the PAF patients experienced severe bradyarrhythmias or rapid ventricular tachyarrhythmias during continuous rhythm monitoring.
Article
Medicine, General & Internal
Huanhuan Zhang, Meng Zhang, Yanru Du, Jinhua He, Jianli Li
Summary: This study reported a case of a 41-year-old female patient diagnosed with gallbladder polyps who underwent laparoscopic cholecystectomy under general anesthesia. During the operation, sudden bradycardia occurred and atropine was administered intravenously, which resulted in ventricular tachycardia and acute heart failure. Immediate treatment was provided and the patient experienced no complications after 6 months of follow-up.
Review
Cardiac & Cardiovascular Systems
James L. Cox, S. Chris Malaisrie, Andrei Churyla, Chris Mehta, Jane Kruse, Olga N. Kislitsina, Patrick M. McCarthy
Summary: Cryosurgery has been used for treating cardiac arrhythmias for decades, but the mechanisms and techniques for producing optimal cryolesions in atrial fibrillation treatment are still not well understood. The creation of effective cryolesions depends on factors such as cryoprobe temperature, target myocardium temperature, duration of cryothermia application, and the presence of a heat or cooling sink. Cryothermia kills myocardial cells during both freezing and thawing phases, with a critical lethal temperature of -30°C for myocardium.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Jin Joo Park, Hae-Young Lee, Kye Hun Kim, Byung-Su Yoo, Seok-Min Kang, Sang Hong Baek, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Byung-Hee Oh, Dong-Ju Choi
Summary: In patients with heart failure (HF) and atrial fibrillation (AF), those whose acute decompensation is tachycardia-mediated have better in-hospital outcomes, but similar post-discharge outcomes compared to those with sinus rhythm or AF whose decompensation is not tachycardia-mediated.
Article
Cardiac & Cardiovascular Systems
Thomas Koertl, Thea Stehle, Dominic Riedl, Johanna Trausel, Sabine Rebs, Steffen Pabel, Michael Paulus, Andreas Holzamer, Nassir Marrouche, Lars S. Maier, Christian Sohns, Katrin Streckfuss-Boemeke, Samuel Sossalla
Summary: In vitro experiments using induced pluripotent stem cell-derived cardiomyocytes revealed that an atrial fibrillation burden higher than 50% led to significant functional and structural alterations, potentially impairing cardiac contractility. These findings aid in explaining the adverse effects of atrial fibrillation burden observed in previous clinical studies.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andrei Alexandru Mircea, Mihaela Rusu, Elisa Anamaria Liehn, Octavian Bucur
Summary: This review focuses on newly developed strategies, such as vernakalant and stereotactic ablative therapy, for the treatment of arrhythmias. These therapies are important for improving the management of atrial fibrillation and ventricular tachycardia, offering higher success rates and lower costs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Jonas Rusnak, Michael Behnes, Linda Reiser, Tobias Schupp, Armin Bollow, Thomas Reichelt, Martin Borggrefe, Dominik Ellguth, Niko Engelke, Ibrahim El-Battrawy, Uzair Ansari, Max Barre, Kathrin Weidner, Julian Mueller, Christian Barth, Dirk Grosse Meininghaus, Muharrem Akin, Thomas Bertsch, Gabriel Taton, Ibrahim Akin
Summary: Atrial fibrillation is associated with increased rates of recurrent ventricular tachyarrhythmias and appropriate device therapies in implantable cardioverter defibrillator recipients with ventricular tachyarrhythmias.
ARCHIVES OF CARDIOVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Parag Goyal, Michael Kim, Udhay Krishnan, Stephen A. Mccullough, Jim W. Cheung, Luke K. Kim, Ambarish Pandey, Barry A. Borlaug, Evelyn M. Horn, Monika M. Safford, Hooman Kamel
Summary: The study found that post-operative atrial fibrillation is associated with incident heart failure hospitalization among patients undergoing both cardiac and non-cardiac surgeries. These findings highlight the adverse prognostic impact of post-operative atrial fibrillation and suggest that it may be a marker for identifying patients with subclinical heart failure and those at elevated risk for heart failure.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Zefferino Palama, Antonio Gianluca Robles, Matteo Paoletti, Martina Nesti, Ermenegildo De Ruvo, Antonio Scara, Alessio Borrelli, Gabriele De Masi De Luca, Mariano Rillo, Leonardo Calo, Elena Cavarretta, Silvio Romano, Luigi Sciarra
Summary: The study assessed the inducibility of supraventricular tachycardia (SVT) in patients referred for atrial fibrillation (AF) ablation and the effects of SVT ablation on AF recurrences. It found that 19% of patients had inducible SVT, and SVT ablation had a preventive effect on AF recurrences.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Leonard Bergau, Philipp Bengel, Vanessa Sciacca, Thomas Fink, Christian Sohns, Philipp Sommer
Summary: Atrial fibrillation is the most common sustained arrhythmia worldwide and is strongly associated with heart failure. Two therapeutic strategies, rhythm control and rate control, are accepted as the standard of care in AF patients with heart failure. Recent important studies have investigated the optimal therapeutic strategy in HF patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Lucas Malta Westergaard, Amna Alhakak, Rasmus Rorth, Emil L. Fosbol, Soren L. Kristensen, Jesper H. Svendsen, Claus Graff, Jonas B. Nielsen, Gunnar H. Gislason, Lars Kober, Christian Torp-Pedersen, Christina J. Y. Lee, Peter E. Weeke
Summary: This study aimed to evaluate the risk of new-onset heart failure and all-cause mortality in patients with atrial fibrillation (AF) according to ventricular rate. The results showed that patients with ventricular rates ≥100 bpm had a higher risk of new-onset heart failure and all-cause mortality compared to those with rates of 60-79 bpm. This suggests that ventricular rates ≥100 bpm may be associated with increased risk in AF patients receiving rate control drug treatment.
Article
Cardiac & Cardiovascular Systems
Mohamed B. Elshazly, Bruce L. Wilkoff, Khaldoun Tarakji, Yuping Wu, Eoin Donnellan, Charbel Abi Khalil, Nidal Asaad, Wael Jaber, Oussama Wazni, Leslie Cho
Summary: In patients with HF and AF, higher resting ventricular rate and lower peak exercise ventricular rate are associated with worse exercise capacity, while lower exercise ventricular rate parameters are linked to higher mortality. Further studies are needed to determine if modulating exercise ventricular rate can improve exercise performance and outcomes.
CIRCULATION-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Yogesh N. Reddy, Barry A. Borlaug, Bernard J. Gersh
Summary: Atrial fibrillation is the most common arrhythmia in heart failure patients and can be both the cause and consequence of clinical heart failure. Some patients may benefit from maintaining sinus rhythm with catheter ablation. There is a close relationship between atrial fibrillation, left atrial myopathy, mitral regurgitation, and heart failure with preserved ejection fraction, with potential clinical benefits to catheter ablation therapy. Treatment of atrial fibrillation also requires consideration of the degree of atrial myopathy and chronicity of atrial fibrillation.
Review
Medicine, General & Internal
Michael Derndorfer, Shaojie Chen, Helmut Puererfellner
Summary: Atrial fibrillation (AF) and heart failure (HF) are closely linked, with successful treatment of one potentially benefiting the other; adherence to guidelines is crucial, with AF patients potentially benefiting from ablation and HF patients having alternative treatment options depending on their LVEF levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Jonathan B. Berlowitz, Wubin Xie, Alyssa F. Harlow, Michael J. Blaha, Aruni Bhatnagar, Emelia J. Benjamin, Andrew C. Stokes
Summary: E-cigarette use is associated with pulmonary inflammation, functional respiratory changes, and chronic lung disease. Most population-level E-cigarette research has utilized point-in-time measures of E-cigarette exposures, which may not generalize to adults who transition between cigarettes and E-cigarettes. Transitions from nonuse to exclusive E-cigarette use are associated with increased incidence rate of wheeze, while transitions from cigarettes to E-cigarettes or from dual use to E-cigarette use are associated with reduced incidence rates of wheeze and dry nighttime cough. Further research is needed to assess the risks and benefits of E-cigarette-assisted cigarette cessation.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Darae Ko, Emelia J. Benjamin
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Mathematical & Computational Biology
Qiuxi Huang, Ludovic Trinquart
Summary: When comparing the performance of competing tests, power is commonly focused on in simulation studies. However, comparing tests based solely on power can be misleading if the test sizes differ. We introduce relative positive and negative likelihood ratios to consider both power and size in the comparison of multiple tests, deriving sample size formulas for a comparative simulation study. Using the example of small-study effects in meta-analyses, we demonstrate the limitations of comparing power alone and the benefits of the proposed likelihood ratio approach in accurately evaluating the trade-off between power and size.
BIOMETRICAL JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Amy A. Sarma, Samantha M. Paniagua, Emily S. Lau, Dongyu Wang, Elizabeth E. Liu, Martin G. Larson, Naomi M. Hamburg, Gary F. Mitchell, Jorge Kizer, Bruce M. Psaty, Norrina B. Allen, A. Titia Lely, Ronald T. Gansevoort, Emily Rosenberg, Kenneth Mukamal, Emelia J. Benjamin, Ramachandran S. Vasan, Susan Cheng, Daniel Levy, Rudolf A. de Boer, John S. Gottdiener, Sanjiv J. Shah, Jennifer E. Ho
Summary: This study aimed to explore the relationship between the number of live births and cardiac structure and function. The findings showed that an increased number of live births was associated with worse cardiac structure and function, including impaired left ventricular fractional shortening and cardiac mechanics. Additionally, a higher number of live births was associated with an increased risk of heart failure with reduced ejection fraction, while a lower risk of heart failure with preserved ejection fraction was observed.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Health Care Sciences & Services
Ludovic Trinquart, Chunyu Liu, David McManus, Christopher Nowak, Honghuang Lin, Nicole L. Spartano, Belinda Borrelli, Emelia J. Benjamin, Jonne M. Murabito
Summary: This study aimed to evaluate the impact of smartphone messaging interventions on remote transmission of blood pressure (BP) and heart rate (HR) data. The results showed that personalized notifications increased longitudinal adherence to BP and HR transmission, suggesting that personalized messaging is an effective tool in promoting adherence to mobile health systems in cardiovascular research.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Emelia J. Benjamin, Kevin L. Thomas, Alan S. Go, Patrice Desvigne-Nickens, Christine M. Albert, Alvaro Alonso, Alanna M. Chamberlain, Utibe R. Essien, Inmaculada Hernandez, Mellanie True Hills, Kiarri N. Kershaw, Phillip D. Levy, Jared W. Magnani, Daniel D. Matlock, Emily C. O'Brien, Carlos J. Rodriguez, Andrea M. Russo, Elsayed Z. Soliman, Lawton S. Cooper, Sana M. Al-Khatib
Summary: The contributions of social determinants of health to atrial fibrillation (AF) have received little attention. Social determinants of health affect access to care and management decisions for AF, increasing the likelihood of adverse outcomes among individuals who experience systemic disadvantages. Research is needed to eliminate the substantive inequities in health care delivery and outcomes in AF.
Article
Cardiac & Cardiovascular Systems
Jeremiah Wasserlauf, Kelly Vogel, Cailin Whisler, Emelia Benjamin, Robert Helm, Daniel A. Steinhaus, Omair Yousuf, Rod S. Passman
Summary: The aim of this study was to determine the accuracy of the irregular rhythm notification (IRN) feature of the Apple watch in subjects with a previous diagnosis of nonpermanent atrial fibrillation (AF). The results showed that the IRN had a low rate of false positive detections and high specificity in a population with known AF. However, increased sensitivity and wear times would be necessary for disease management.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Health Care Sciences & Services
Ayelet Shapira-Daniels, Jelena Kornej, Nicole L. Spartano, Xuzhi Wang, Yuankai Zhang, Chathurangi H. Pathiravasan, Chunyu Liu, Ludovic Trinquart, Belinda Borrelli, David McManus, Joanne M. Murabito, Emelia J. Benjamin, Honghuang Lin
Summary: This study investigated the association between daily step count and the predicted 5-year risk of atrial fibrillation (AF). It found that every 1000 steps were associated with a 0.08% lower AF risk. The association was stronger in men and individuals with obesity. The use of a wearable daily step counter for reducing AF risk deserves further investigation.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Reza Mohebi, Dongyu Wang, Emily S. Lau, Juhi K. Parekh, Norrina Allen, Bruce M. Psaty, Emelia J. Benjamin, Daniel Levy, Thomas J. Wang, Sanjiv J. Shah, John S. Gottdiener, James L. Januzzi, Jennifer E. Ho
Summary: This study compares the prevalence and prognosis of heart failure (HF) stages according to the 2013 and 2022 ACC/AHA/HFSA definitions. The new standards result in a substantial shift of individuals from stage A to stage B, and those in stage B have a higher risk of progression to symptomatic HF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Computer Science, Information Systems
Carl G. Streed Jr, Dana King, Chris Grasso, Sari L. Reisner, Kenneth H. Mayer, Guneet K. Jasuja, Tonia Poteat, Monica Mukherjee, Ayelet Shapira-Daniels, Howard Cabral, Vin Tangpricha, Michael K. Paasche-Orlow, Emelia J. Benjamin
Summary: The study aims to validate an algorithm for identifying transgender and gender diverse (TGD) patients within electronic health record (EHR) data and evaluate its accuracy. The algorithm was validated in an EHR data set with self-reported gender identity using TGD-related diagnosis and procedure codes, and hormone therapy prescription data. The results showed that the algorithm had good sensitivity, specificity, positive predictive value, and negative predictive value in identifying TGD patients in administrative data. Further categorization based on prescription data also had high accuracy.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Gary F. Mitchell, Jian Rong, Martin G. Larson, Leroy L. Cooper, Vanessa Xanthakis, Emelia J. Benjamin, Naomi M. Hamburg, Ramachandran S. Vasan
Summary: Systolic blood pressure increases with age after midlife, particularly in women, and contributes to development of wide pulse pressure hypertension in middle-aged and older adults. The relative contributions of aortic stiffness and premature wave reflection to increases in pulse pressure remain controversial.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Yi Li, Ayana Gray, Liying Xue, Melissa G. Farb, Nir Ayalon, Charlotte Andersson, Darae Ko, Emelia J. Benjamin, Daniel Levy, Ramachandran S. Vasan, Martin G. Larson, Jian Rong, Vanessa Xanthakis, Chunyu Liu, Jessica L. Fetterman, Deepa M. Gopal
Summary: This study investigates the association between metabolomics and cardiovascular health (CVH) and finds that certain metabolites mediate the relationship between CVH and the development of atrial fibrillation (AF) and heart failure (HF).
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Clinical Neurology
Lu-Chen Weng, Shaan Khurshid, Sophia Gunn, Ludovic L. Trinquart, Kathryn Lunetta, Huichun J. Xu, Patrick T. NINDS Stroke Genetics Network, Emelia D. Benjamin, Patrick A. Ellinor, Christopher Anderson, Steven Lubitz
Summary: The polygenic risk score for atrial fibrillation can help distinguish between cardioembolic and noncardioembolic strokes. It improves the discrimination and reclassification of stroke subtypes when combined with clinical risk factors.
Review
Health Care Sciences & Services
Ellen Boakye, John Erhabor, Olufunmilayo Obisesan, Erfan Tasdighi, Mohammadhassan Mirbolouk, Ngozi Osuji, Albert D. Osei, Jieun Lee, Andrew P. Defilippis, Andrew C. Stokes, Glenn A. Hirsch, Emelia J. Benjamin, Rose Marie Robertson, Aruni Bhatnagar, Omar El Shahawy, Michael J. Blaha
Summary: Surveillance of e-cigarette use is crucial for evaluating tobacco regulatory policies. This review identified 13 national epidemiologic surveys that assess e-cigarette use among U.S. youth and adults, which have been instrumental in e-cigarette surveillance. These surveys vary in scope and detail, providing unique strengths and the ability to answer specific regulatory questions.
LANCET REGIONAL HEALTH-AMERICAS
(2023)
