Review
Immunology
Jun Wang, Miriam Erlacher, Juncal Fernandez-Orth
Summary: Under inflammatory conditions, steady-state hematopoiesis switches to emergency myelopoiesis, leading to different forms of cell death and other changes in the hematopoietic system, ultimately causing loss of hematopoiesis function. In individuals with inherited bone marrow failure syndromes or immune-mediated aplastic anemia, chronic inflammatory signals may aggravate disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Zengdi Zhang, Zan Huang, Mohamed Awad, Mohammed Elsalanty, James Cray, Lauren E. Ball, Jason C. Maynard, Alma L. Burlingame, Hu Zeng, Kim C. Mansky, Hai-Bin Ruan
Summary: In mammals, the interaction between bone marrow stroma and hematopoietic progenitors contributes to bone-BM homeostasis, but the mechanisms and interactions between the development of skeletal and hematopoietic systems are largely unknown. This study reveals that the intracellular O-GlcNAc modification plays a role in dictating the fate and function of early BM stromal cells (BMSCs). O-GlcNAcylation promotes osteogenic differentiation of BMSCs and supports lymphopoiesis, while inhibiting adipogenesis and myelopoiesis. Impaired bone formation and defective hematopoiesis were observed when O-GlcNAc transferase (OGT) was ablated in BMSCs.
Review
Endocrinology & Metabolism
Ziru Li, Clifford J. Rosen
Summary: Bone marrow adipose tissue (BMAT) is a significant component of the bone marrow space in healthy adults, but its expansion is associated with aging, obesity, anorexia nervosa, and irradiation. While traditionally viewed as a negative component, recent studies have revealed that BMAT can serve as an energy reservoir and also plays a role in regulating bone formation and hematopoiesis. This review summarizes the unique characteristics of BMAT and provides an updated understanding of its physiological roles based on a newly established mouse model.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Immunology
Charlotte Hellmich, Edyta E. Wojtowicz
Summary: Normal bone marrow homeostasis relies on a steady supply of nutrients, and changes in metabolite demands can occur in response to infection and immune stress. The right balance of dietary components helps maintain normal homeostasis and cope with systemic stress. Some dietary components can also lead to chronic inflammation, impacting immune function. Optimal nutrition supports immune cell functions to effectively combat pathogens and resolve responses, while avoiding chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jianfang Wang, Qiaoling Zhu, Dandan Cao, Qiqi Peng, Xiaoying Zhang, Chong Li, Chen Zhang, Bo O. Zhou, Rui Yue
Summary: This study identifies bone marrow stromal cells (BMSCs) and megakaryocytes/platelets (MKs/PLTs) as two important sources of IGF-1 that coordinate to maintain and regenerate the adult skeleton, highlighting reciprocal regulation between the hematopoietic and skeletal systems.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Weizhou Wang, Yanghao Wang, Zhihong Tang, Yongcheng Chen, Zhui Liu, Hao Duan, Zongyu Zhong, Fei He
Summary: MSCs transplantation effectively promoted bone density and trabecular number in ovariectomized mice, as well as enhanced vascular repair and prevented osteoporosis development in mice with femoral artery ligation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Dan Huang, Guohuan Sun, Xiaoxin Hao, Xiaoxiao He, Zhaofeng Zheng, Chiqi Chen, Zhuo Yu, Li Xie, Shihui Ma, Ligen Liu, Bo O. Zhou, Hui Cheng, Junke Zheng, Tao Cheng
Summary: Reducing SEV production from endothelial cells significantly delays leukemia progression, without affecting normal hematopoiesis. These findings reveal a role of niche-specific SEVs in cancer development and suggest that targeting ANGPTL2-SEVs released from endothelial cells may be a potential strategy to interfere with certain types of AML.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Steven J. Greco, Seda Ayer, Khadidiatou Guiro, Garima Sinha, Robert J. Donnelly, Markos H. El-Far, Lauren S. Sherman, Yannick Kenfack, Sri Harika Pamarthi, Marina Gergues, Oleta A. Sandiford, Michael J. Schonning, Jean -Pierre Etchegaray, Pranela Rameshwar
Summary: This study demonstrates the potential to reverse age-associated morbidity by restoring the aged hematopoietic system using miRNA cargo to target specific genes. By introducing restorative miRs in aged cells, improvements in aged hallmarks such as altered lymphoid:myeloid ratio, decreased inflammation, and cellular senescence were observed. Additionally, the study found that natural killer cells can eliminate dormant breast cancer cells in vivo, indicating the broad relevance of this approach in preventing and reversing age-associated disorders.
Article
Multidisciplinary Sciences
Rida Al-Rifai, Marie Vandestienne, Jean-Remi Lavillegrand, Tristan Mirault, Julie Cornebise, Johanne Poisson, Ludivine Laurans, Bruno Esposito, Chloe James, Olivier Mansier, Pierre Hirsch, Fabrizia Favale, Rayan Braik, Camille Knosp, Jose Vilar, Giuseppe Rizzo, Alma Zernecke, Antoine-Emmanuel Saliba, Alain Tedgui, Maxime Lacroix, Lionel Arrive, Ziad Mallat, Soraya Taleb, Marc Diedisheim, Clement Cochain, Pierre-Emmanuel Rautou, Hafid Ait-Oufella
Summary: JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm.
NATURE COMMUNICATIONS
(2022)
Article
Hematology
Peng Li, Shobi Venkatachalam, Daniela Ospina Cordona, Lorena Wilson, Tibor Kovacsovics, Karen A. Moser, Rodney R. Miles, David B. Beck, Tracy George, Srinivas K. Tantravahi
Summary: This article describes the characteristic hematologic findings in patients with VEXAS, including anemia, thrombocytopenia, and bone marrow hyperplasia. It provides awareness of the clinical and hematologic features of this disease, helping to improve the accuracy of diagnosis.
Review
Chemistry, Multidisciplinary
Chao Ye, Fen Zheng, Nan Wu, Guo-qing Zhu, Xiu-zhen Li
Summary: Vascular remodeling plays a crucial role in the development of various vascular diseases and is closely associated with the release of extracellular vesicles (EVs). EVs impact vascular remodeling by affecting oxidative stress, inflammation, calcification, and lipid plaque formation. Therefore, EVs have the potential to be used as biomarkers for diagnosis and prognosis, as well as therapeutic targets for vascular remodeling and cardiovascular diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Endocrinology & Metabolism
Matthew J. Kim, Rodrigo J. Valderrabano, Joy Y. Wu
Summary: This article discusses various populations of osteoblasts at different stages of differentiation and summarizes the role of the osteoblast lineage in supporting hematopoiesis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Hematology
Thomas Breuer, Michael Jimenez, Jay D. Humphrey, Toshiharu Shinoka, Christopher K. Breuer
Summary: The research group has been using regenerative medicine strategies to develop improved biomaterials for congenital heart surgery for over 25 years. They have successfully developed a tissue-engineered vascular graft (TEVG) by combining tubular biodegradable polymeric scaffolds with autologous bone marrow-derived mononuclear cells. However, the first clinical trial revealed a high incidence of early TEVG stenosis, which hindered its widespread use. Through animal models and computational simulations, the group discovered the mechanism of TEVG stenosis and designed strategies to inhibit it.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Medical Laboratory Technology
Na He, Min Liu, Yue Wu
Summary: Hematopoietic stem cells are the origin of all blood cells, with the ability to self-renew and differentiate. Bone marrow adipocytes play important roles in regulating hematopoiesis, with conflicting effects on the process.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Review
Nutrition & Dietetics
Fabiana Da Silva Lima, Carlos Eduardo Da Silva Goncalves, Ricardo Ambrosio Fock
Summary: There has been a global increase in the older population in recent decades, leading to complex metabolic and epigenetic changes that may trigger health complications. Older individuals may experience reduced dietary intake or nutrient absorption, affecting tissues with high nutrient requirements. Hematopoiesis, the process of blood cell formation, is particularly susceptible to factors like aging and micronutrient deficiency, including zinc. This review aims to explore the relationship between zinc and the regulation of hematopoietic tissue, shedding light on its potential role in age-related disorders.
Article
Hematology
Shin-Young Park, Alessandro Matte, Yookyung Jung, Jina Ryu, Wilson Babu Anand, Eun-Young Han, Min Liu, Carmine Carbone, Davide Melisi, Takashi Nagasawa, Joseph J. Locascio, Charles P. Lin, Leslie E. Silberstein, Lucia De Franceschi
Article
Cardiac & Cardiovascular Systems
Sebastian Cremer, Maximilian J. Schloss, Claudio Vinegoni, Brody H. Foy, Shuang Zhang, David Rohde, Maarten Hulsmans, Paolo Fumene Feruglio, Stephen Schmidt, Greg Wojtkiewicz, John M. Higgins, Ralph Weissleder, Filip K. Swirski, Matthias Nahrendorf
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Review
Cardiac & Cardiovascular Systems
Wolfram C. Poller, Matthias Nahrendorf, Filip K. Swirski
CIRCULATION RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Maximilian J. Schloss, Filip K. Swirski, Matthias Nahrendorf
CIRCULATION RESEARCH
(2020)
Article
Nanoscience & Nanotechnology
Max L. Senders, Anu E. Meerwaldt, Mandy M. T. van Leent, Brenda L. Sanchez-Gaytan, Jan C. van de Voort, Yohana C. Toner, Alexander Maier, Emma D. Klein, Nathaniel A. T. Sullivan, Alexandros Marios Sofias, Hannah Groenen, Christopher Faries, Roderick S. Oosterwijk, Esther M. van Leeuwen, Francois Fay, Elena Chepurko, Thomas Reiner, Raphael Duivenvoorden, Lior Zangi, Rick M. Dijkhuizen, Sjoerd Hak, Filip K. Swirski, Matthias Nahrendorf, Carlos Perez-Medina, Abraham J. P. Teunissen, Zahi A. Fayad, Claudia Calcagno, Gustav J. Strijkers, Willem J. M. Mulder
NATURE NANOTECHNOLOGY
(2020)
Article
Cell Biology
Jouha Min, Lip Ket Chin, Juhyun Oh, Christian Landeros, Claudio Vinegoni, Jeeyeon Lee, Soo Jung Lee, Jee Young Park, Ai-Qun Liu, Cesar M. Castro, Hakho Lee, Hyungsoon Im, Ralph Weissleder
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Alexander Heyde, David Rohde, Cameron S. McAlpine, Shuang Zhang, Friedrich F. Hoyer, Jeffrey M. Gerold, David Cheek, Yoshiko Iwamoto, Maximilian J. Schloss, Katrien Vandoorne, Oriol Iborra-Egea, Christian Munoz-Guijosa, Antoni Bayes-Genis, Johannes G. Reiter, Morgan Craig, Filip K. Swirski, Matthias Nahrendorf, Martin A. Nowak, Kamila Naxerova
Summary: Clonal hematopoiesis, a condition where certain hematopoietic stem cell clones generate a disproportionate fraction of blood leukocytes, is correlated with increased risk for cardiovascular disease. Research shows that in individuals with atherosclerosis, hematopoietic stem cell division rates are elevated, leading to an increased risk of clonal hematopoiesis. The study suggests that increased hematopoietic stem cell proliferation is an important factor contributing to the association between cardiovascular disease and clonal hematopoiesis.
Article
Multidisciplinary Sciences
Cameron S. McAlpine, Joseph Park, Ana Griciuc, Eunhee Kim, Se Hoon Choi, Yoshiko Iwamoto, Mate G. Kiss, Kathleen A. Christie, Claudio Vinegoni, Wolfram C. Poller, John E. Mindur, Christopher T. Chan, Shun He, Henrike Janssen, Lai Ping Wong, Jeffrey Downey, Sumnima Singh, Atsushi Anzai, Florian Kahles, Mehdi Jorfi, Paolo Fumene Feruglio, Ruslan Sadreyev, Ralph Weissleder, Benjamin P. Kleinstiver, Matthias Nahrendorf, Rudolph E. Tanzi, Filip K. Swirski
Summary: Communication within the glial cell ecosystem is essential for neuronal and brain health. This study demonstrates that astrocyte-sourced interleukin-3 programs microglia to ameliorate the pathology of Alzheimer's disease by enhancing their ability to clear aggregates of beta-amyloid and tau, ultimately restricting disease progression and cognitive decline. These findings highlight IL-3 as a key mediator of astrocyte-microglia cross-talk and a potential therapeutic target for Alzheimer's disease.
Review
Medicine, General & Internal
Ashish Tiwari, Betsalel Elgrably, Galit Saar, Katrien Vandoorne
Summary: Cardiovascular diseases cause systemic changes in the blood vessels, particularly in the endothelial cells that line them. Inflammation triggers adjustments in endothelial cells, leading to changes in blood flow and permeability, expression of adhesion molecules, vessel wall inflammation, thrombosis, angiogenic processes, and extracellular matrix production. Advancements in imaging techniques have allowed for preclinical multi-scale imaging of these endothelial changes, providing insights into vascular biology and potential diagnostic applications in managing cardiovascular diseases.
FRONTIERS IN MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Jina Ko, Martin Wilkovitsch, Juhyun Oh, Rainer H. Kohler, Evangelia Bolli, Mikael J. Pittet, Claudio Vinegoni, David B. Sykes, Hannes Mikula, Ralph Weissleder, Jonathan C. T. Carlson
Summary: SAFE is a method for comprehensive longitudinal imaging of living cells using immunofluorescence, allowing multiparameter temporal and spatial imaging. It is non-toxic and functional in various living samples.
NATURE BIOTECHNOLOGY
(2022)
Article
Neurosciences
Fadi E. Pulous, Jean C. Cruz-Hernandez, Chongbo Yang, Zeynep Kaya, Alexandre Paccalet, Gregory Wojtkiewicz, Diane Capen, Dennis Brown, Juwell W. Wu, Maximilian J. Schloss, Claudio Vinegoni, Dmitry Richter, Masahiro Yamazoe, Maarten Hulsmans, Noor Momin, Jana Grune, David Rohde, Cameron S. McAlpine, Peter Panizzi, Ralph Weissleder, Dong-Eog Kim, Filip K. Swirski, Charles P. Lin, Michael A. Moskowitz, Matthias Nahrendorf
Summary: Interactions between the immune and central nervous systems are crucial for brain health. Meningeal gateways through brain border tissues facilitate communication between these systems. The cerebrospinal fluid can exit into the skull bone marrow, allowing outward signaling beyond the blood-brain barrier.
NATURE NEUROSCIENCE
(2022)
Article
Oncology
Muhammad Ali, Giulia Fulci, Mantas Grigalavicius, Benjamin Pulli, Anning Li, Gregory R. Wojtkiewicz, Cuihua Wang, Kevin Li-Chun Hsieh, Jenny J. Linnoila, Theodossis A. Theodossiou, John W. Chen
Summary: The study illustrates that post-radiation MPO activity has significant impacts on tumor development and survival outcomes, with MPO inhibition or absence leading to increased tumor growth and decreased host survival.
Article
Multidisciplinary Sciences
Seung-Hyun Jung, Byung-Hee Hwang, Sun Shin, Eun-Hye Park, Sin-Hee Park, Chan Woo Kim, Eunmin Kim, Eunho Choo, Ik Jun Choi, Filip K. Swirski, Kiyuk Chang, Yeun-Jun Chung
Summary: Heart failure is a common consequence of myocardial infarction. This study used spatial transcriptomics and single-cell RNA-sequencing to investigate the dynamics of immune cells after myocardial infarction in a mouse model. The researchers identified twelve major immune cell populations, with macrophages being the most abundant. They found that Trem2 expression in macrophages was upregulated during the late phase after myocardial infarction. Injection of soluble Trem2 led to significant improvements in functional and structural aspects of infarcted hearts.
NATURE COMMUNICATIONS
(2022)
Review
Neurosciences
Kenny L. Chan, Wolfram C. Poller, Filip K. Swirski, Scott J. Russo
Summary: Stress is associated with psychiatric disorders and systemic inflammation. Recent studies have shown that stress alters haematopoiesis and leads to inflammation in peripheral tissues. This peripheral inflammation contributes to the development of psychiatric symptoms and co-morbidities.
NATURE REVIEWS NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Maarten Hulsmans, Maximilian J. Schloss, I-Hsiu Lee, Aneesh Bapat, Yoshiko Iwamoto, Claudio Vinegoni, Alexandre Paccalet, Masahiro Yamazoe, Jana Grune, Steffen Pabel, Noor Momin, Hana Seung, Nina Kumowski, Fadi E. Pulous, Daniel Keller, Constanze Bening, Ursula Green, Jochen K. Lennerz, Richard N. Mitchell, Andrew Lewis, Barbara Casadei, Oriol Iborra-Egea, Antoni Bayes-Genis, Samuel Sossalla, Chin Siang Ong, Richard N. Pierson, Jon C. Aster, David Rohde, Gregory R. Wojtkiewicz, Ralph Weissleder, Filip K. Swirski, George Tellides, George Tolis, Serguei Melnitchouk, David J. Milan, Patrick T. Ellinor, Kamila Naxerova, Matthias Nahrendorf
Summary: This study deciphered the role of immune and stromal cells in atrial fibrillation and identified SPP1(+) macrophages as potential targets for immunotherapy in atrial fibrillation.