Review
Cardiac & Cardiovascular Systems
Gbolahan Olatunji, Emmanuel Kokori, Ismaila Yusuf, Emmanuel Ayanleke, Olakanmi Damilare, Samson Afolabi, Busayo Adetunji, Saad Mohammed, Olumide Akinmoju, Gbolahan Aboderin, Nicholas Aderinto
Summary: This review explores the evolving landscape of stem cell-based therapies for heart failure management, including mechanisms of action, clinical evidence, ethical considerations, and regulatory challenges. Key findings include the potential for improved cardiac function, enhanced quality of life, and long-term benefits associated with stem cell therapies. Future directions include optimizing stem cell types, delivery techniques, dosing strategies, and long-term safety assessments to improve efficacy and safety.
HEART FAILURE REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Gregory J. Bittle, David Morales, Nicholas Pietris, Nathaniel Parchment, Dawn Parsell, Kiel Peck, Kristopher B. Deatrick, Luis Rodriguez-Borlado, Rachel R. Smith, Linda Marban, Sunjay Kaushal
Summary: In a juvenile porcine model, human CDC-derived exosome administration showed significant preservation of RV systolic function in the setting of acute pressure overload, leading to improved cardiac function and reduced cardiomyocyte hypertrophy. These acellular preparations may be superior to whole cells and represent a novel therapeutic approach to clinical myocardial injury.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Lilian Grigorian-Shamagian, Ricardo Sanz-Ruiz, Andreu Climent, Lina Badimon, Lucio Barile, Roberto Bolli, Steven Chamuleau, Diederick E. Grobbee, Stefan Janssens, Jens Kastrup, Leyla Kragten-Tabatabaie, Rosalinda Madonna, Anthony Mathur, Philippe Menasche, Giulio Pompilio, Felipe Prosper, Emily Sena, Nicola Smart, Wolfgram-Hubertus Zimmermann, Francisco Fernandez-Aviles
Summary: The text highlights the potential and challenges of regenerative and reparative medicine in the treatment of cardiovascular diseases, particularly heart failure. It discusses the discrepancies between preclinical studies and clinical trials, as well as the barriers to clinical translation. It also calls for a better preparation for stem cell and gene therapy products in the clinical setting.
CARDIOVASCULAR RESEARCH
(2021)
Review
Polymer Science
Cecilie Hoeeg, Alireza Dolatshahi-Pirouz, Bjarke Follin
Summary: Cell therapy has the potential to regenerate cardiac tissue and treat various cardiac diseases. Injectable hydrogels have been investigated for their potential to improve cell graft retention and enhance the effects of cardiac cell therapy.
Review
Biochemistry & Molecular Biology
Matthias Mietsch, Rabea Hinkel
Summary: With the prevalence of cardiovascular diseases, there is an urgent need for new treatment strategies. While stem cell based approaches have shown promise in improving cardiac functions, recent research has highlighted the potential importance of mitochondria in these treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Hsuan Peng, Kazuhiro Shindo, Renee R. Donahue, Ahmed Abdel-Latif
Summary: Stem cell-based cardiac therapies present challenges in cell delivery, engraftment, and differentiation, but still lead to sustained cardiac benefits. Current research focuses on exploring the mechanisms of stem cell-mediated cardiac immunomodulation, with efforts to improve current strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Javier Morales, Yehuda Handelsman
Summary: Chronic kidney disease (CKD) and cardiovascular disease (CVD) are significantly related in diabetic patients. Controlling blood pressure, dyslipidemia, and glucose levels is a common treatment approach, but a high residual risk remains. This review focuses on pharmacotherapy for patients, exploring new and existing cardiorenal therapies to reduce cardiovascular risk beyond traditional treatments. Ongoing studies are expected to provide further insights into potential synergistic effects.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Reem Saud Alhejailan, Gloria Garoffolo, Vineesh Vimala Raveendran, Maurizio Pesce
Summary: After more than 20 years of research in regenerative medicine, the best cell types and materials to effectively translate into clinical practice for cardiac diseases are still uncertain. It is now clear that the heart lacks a consistent reservoir of stem cells for generating new myocytes, and other cells may only contribute with their pro-angiogenic or immunomodulatory potential. New developments in somatic cells' reprogramming, material science, and cell biophysics may be helpful in protecting the heart and enhancing its lost regenerative potential.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Loan Bui, Shanique Edwards, Eva Hall, Laura Alderfer, Kellen Round, Madeline Owen, Pietro Sainaghi, Siyuan Zhang, Prakash D. Nallathamby, Laura S. Haneline, Donny Hanjaya-Putra
Summary: This study presents a strategy to improve the vasculogenic potential of vascular progenitor cells exposed to gestational diabetes mellitus by conjugating drug-loaded liposomal nanoparticles to the surface of the cells. The strategy successfully rejuvenates the cells and improves their therapeutic potential, offering a promising approach to address cardiovascular complications and advance tissue repair and regenerative medicine.
COMMUNICATIONS BIOLOGY
(2022)
Article
Medicine, General & Internal
Teruhiko Imamura, Nikhil Narang, Koichiro Kinugawa
Summary: The retrospective analysis of consecutive patients receiving Pemafibrate therapy suggests that it may have the potential to lower the triglyceride/HDL-cholesterol ratio and decrease cardiovascular events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yuki Hida, Teruhiko Imamura, Koichiro Kinugawa
Summary: This retrospective study found that pemafibrate therapy can reduce the levels of small dense LDL-cholesterol in patients with hypertriglyceridemia. The treatment also significantly decreased the rate of cardiovascular events.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Jyotsna Joshi, Bing Xu, Michael Rubart, Yun Chang, Xiaoping Bao, Hari P. Chaliki, Luis R. Scott, Wuqiang Zhu
Summary: This study established an in vivo model for optogenetic-based modulation of the excitability of donor cardiomyocytes, providing unique value for studying electromechanical coupling and molecular interactions between donor cardiomyocytes and recipient hearts in live animals.
Review
Biochemistry & Molecular Biology
Lindsay Kraus, Brianna Beavens
Summary: Cardiovascular diseases are a leading global cause of death, lacking a cure. Epigenetics and chromatin remodeling have emerged as promising interventions. Recent advancements in bioinformatics and gene therapy have particularly advanced the field of chromatin remodeling, specifically for the treatment of heart failure. Understanding changes to chromatin architecture has revealed potential methods for altering the progression of cardiac diseases through genomic sequencing, targeting cardiac genes, utilizing RNA molecules, and employing chromatin remodeler complexes. This understanding may lead to individualized pharmaceutical interventions and biomarkers for major disease states, ultimately paving the way for future therapeutic approaches.
Review
Biochemistry & Molecular Biology
Arianne Caudal, Lu Ren, Chengyi Tu, Joseph C. Wu
Summary: This review summarizes the recent advancements in the study of mitochondrial diseases of the heart, emphasizing the importance of using iPSC-CMs for research in this field.
Article
Cardiac & Cardiovascular Systems
Patrick B. Mark, Juan J. Carrero, Kunihiro Matsushita, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Josef Coresh, Aditya Surapaneni, Nigel J. Brunskill, John Chalmers, Lili Chan, Alex R. Chang, Rajkumar Chinnadurai, Gabriel Chodick, Massimo Cirillo, Dick de Zeeuw, Marie Evans, Amit X. Garg, Orlando M. Gutierrez, Hiddo J. L. Heerspink, Gunnar H. Heine, William G. Herrington, Junichi Ishigami, Florian Kronenberg, Jun Young Lee, Adeera Levin, Rupert W. Major, Angharad Marks, Girish N. Nadkarni, David M. J. Naimark, Christoph Nowak, Mahboob Rahman, Charumathi Sabanayagam, Mark Sarnak, Simon Sawhney, Markus P. Schneider, Varda Shalev, Jung-Im Shin, Moneeza K. Siddiqui, Nikita Stempniewicz, Keiichi Sumida, Jose M. Valdivielso, Jan van den Brand, Angela Yee-Moon Wang, David C. Wheeler, Lihua Zhang, Frank L. J. Visseren, Benedicte Stengel
Summary: This study investigated the association between cardiovascular disease (CVD) and future risk of kidney failure with replacement therapy (KFRT). It found that both prevalent and incident CVD were strongly associated with KFRT risk, with incident HF showing the strongest association.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
David E. Ebeid, Farid G. Khalafalla, Kathleen M. Broughton, Megan M. Monsanto, Carolina Y. Esquer, Veronica Sacchi, Nirmala Hariharan, Kelli Korski, Maryam Moshref, Jacqueline Emathinger, Christopher T. Cottage, Pearl J. Quijada, Jonathan H. Nguyen, Roberto Alvarez, Mirko Volkers, Mathias H. Konstandin, Bingyan J. Wang, Fareheh Firouzi, Julian M. Navarrete, Natalie A. Gude, Marie-Jose Goumans, Mark A. Sussman
Summary: Pim1 maintains telomere lengths in cardiomyocytes by inhibiting phosphorylation of the TGF beta pathway downstream effectors Smad2 and Smad3, which prevents repression of telomerase reverse transcriptase.
CARDIOVASCULAR RESEARCH
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Megan M. Monsanto, Fareheh Firouzi, Mark A. Sussman
CARDIOVASCULAR RESEARCH
(2021)
Article
Engineering, Biomedical
Jaeyeaon Cho, Sangsung Kim, Hyein Lee, Woongchan Rah, Hee Cheol Cho, Nam Kyun Kim, Seongho Bae, Dong Hoon Shin, Min Goo Lee, In-Hyun Park, Yoshiaki Tanaka, Eric Shin, Hong Yi, Ji Woong Han, Patrick Tae Joon Hwang, Ho-Wook Jun, Hun-Jun Park, Kyuwon Cho, Sang Wook Lee, Jae Kyung Jung, Rebecca D. Levit, Mark A. Sussman, Richard P. Harvey, Young-sup Yoon
Summary: The direct reprogramming of mouse fibroblasts into cardiomyocytes, endothelial cells, and smooth muscle cells to form cardiac tissue structures improved cardiac function when implanted into infarcted mouse hearts.
NATURE BIOMEDICAL ENGINEERING
(2021)
Review
Cardiac & Cardiovascular Systems
Oscar Echeagaray, Clarissa Savko, Andrea Gallo, Mark Sussman
Summary: This review summarizes the cardiovascular consequences of vaping and highlights the importance of research in this area. Recent findings indicate that vaping can have an impact on cardiovascular homeostasis, inflammation, and molecular changes, suggesting potential health issues associated with vaping and the need for further investigation into the pathogenesis.
CURRENT OPINION IN CARDIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Oscar Echeagaray, Taeyong Kim, Alex Casillas, Megan Monsanto, Mark Sussman
Summary: Ex vivo expansion of cells is crucial in regenerative medicine to generate large populations for therapeutic use. The adaptation to culture conditions leads to increased transcriptome diversity and decreased population heterogeneity in cKit+ cardiac interstitial cells (cCICs). The transcriptional profiles of cells from different origins, such as neonatal versus adult tissue, show contrasting imprint of age influence on cell cycle, senescence, RNA transport, and ECM-receptor/fibrosis pathways.
Article
Biology
Carolina Esquer, Oscar Echeagaray, Fareheh Firouzi, Clarissa Savko, Grant Shain, Pria Bose, Abigail Rieder, Sophie Rokaw, Andrea Witon-Paulo, Natalie Gude, Mark A. Sussman
Summary: Vaping of flavored liquids can lead to pulmonary injury, with profound pathological changes in upper airway, lung tissue, and cellular structure. This study also highlights the potential transcriptional reprogramming and impaired cardiac function associated with vaping.
LIFE SCIENCE ALLIANCE
(2022)
Review
Pharmacology & Pharmacy
Mark A. Sussman
Summary: Modern vaping, a rapidly growing industry, has raised concerns about its impact on human health, particularly on the lungs and cardiopulmonary system. Studies are urgently needed to understand the biological effects of vaping and develop strategies to mitigate the associated harmful effects.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Kathleen Broughton, Carolina Esquer, Oscar Echeagaray, Fareheh Firouzi, Grant Shain, David Ebeid, Megan Monsanto, Dena Yaareb, Leila Golgolab, Natalie Gude, Mark A. Sussman
Summary: This study reveals that surface Lin28A serves as a marker for oxidative stress in cardiac interstitial cells (CICs) and its expression can be antagonized by antioxidant treatment. The altered localization of Lin28A is associated with senescence markers and oxidative stress pathways in CICs. These findings provide important insights into the mechanisms of cardiac stress and aging.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fareheh Firouzi, Oscar Echeagaray, Carolina Esquer, Natalie A. Gude, Mark A. Sussman
Summary: The heterogeneity and plasticity of cardiac fibroblast population pose challenges for the study of cardiac biology and intervention strategies. This study evaluates the role of c-Kit biology within the population of cardiac fibroblasts, providing a fundamental basis for future research.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kathleen M. Broughton, Carolina Esquer, Oscar H. Echeagaray, Fareheh Firouzi, Grant Shain, David Ebeid, Megan M. Monsanto, Dena Yaareb, Leila Golgolab, Natalie A. Gude, Mark A. Sussman
Meeting Abstract
Cardiac & Cardiovascular Systems
Mark A. Sussman, Clarissa Savko, Pria Bose, Sophie Rokaw, Abbie Rieder, Taha Alani, Tyler Hopkins, Carolina Esquer, Grant Shain
CIRCULATION RESEARCH
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Oscar E. Echeagaray, Taeyong Kim, Alex Casillas, Megan M. Monsanto, Mark A. Sussman
Meeting Abstract
Cardiac & Cardiovascular Systems
Fareheh Firouzi, Oscar H. Echeagaray, Carolina Y. Esquer, Natalie A. Gude, Mark A. Sussman
Meeting Abstract
Cardiac & Cardiovascular Systems
Kathleen M. Broughton, Carolina Esquer, Oscar Echeagaray, Mark A. Sussman
Meeting Abstract
Cardiac & Cardiovascular Systems
Mark A. Sussman, Carolina Esquer, Clarissa Savko, Grant Shain, Oscar E. Echeagaray, Fareheh Firouzi, Pria Bose, Abbie Rieder, Sophie Rokaw, Andrea Witon-Paulo, Natalie A. Gude
CIRCULATION RESEARCH
(2021)
