Article
Multidisciplinary Sciences
Antonio Molina, Eva Miedes, Laura Bacete, Tinguaro Rodriguez, Hugo Melida, Nicolas Denance, Andrea Sanchez-Vallet, Marie-Pierre Riviere, Gemma Lopez, Amandine Freydier, Xavier Barlet, Sivakumar Pattathil, Michael Hahn, Deborah Goffner
Summary: Plant cell walls play a crucial role in disease resistance responses, with Arabidopsis cell wall mutants showing altered resistance responses to different pathogens compared to wild-type plants. Enhanced resistance of the mutants negatively impacted their fitness traits, despite not involving canonical immune pathways, suggesting the importance of plant wall composition in immune response modulation and trade-offs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Veterinary Sciences
Donald Sockett, Ryan M. Breuer, Lindsey W. Smith, Nicholas S. Keuler, Thomas Earleywine
Summary: This study investigates the use of a digital Brix refractometer to predict colostrum IgG concentration. The results show that the refractometer is not suitable for predicting IgG concentration, but different %Brix cutoffs can be used for estimating minimum colostral IgG concentrations.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sheng-Nan Yuan, Cai-Yun Feng, Yao Rong, Xu Guo, Ying-Ying Chen, M. Fraga-Corral, Miguel A. Prieto, Xiao-Yue Zhang, Ning-Yang Li, Chao Liu, Jin-Yue Sun
Summary: This study investigated the immunomodulatory potential of nervonic acid (NA) on murine RAW264.7 macrophages. The effects of NA were evaluated through various assays and techniques, including assessment of nitric oxide levels, cytokine secretion, phagocytic activity, reactive oxygen species generation, and NF-κB signaling pathway. The results showed that NA can promote the production of NO, TNF-α, IL-1β, IL-6, and ROS in RAW264.7 cells, and upregulate the expression of iNOS, TNF-α, IL-1β, and IL-6 mRNA. Additionally, NA increased the expression of TLR4 protein and the phosphorylation level of NF-κB in a concentration-dependent manner. In conclusion, NA has immunomodulatory potential by activating the NF-κB signaling pathway through the TLR4 signaling pathway.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Immunology
Huiying Pan, Zhiyuan Wu, Haiping Zhang, Jie Zhang, Yue Liu, Zhiwei Li, Wei Feng, Guiqi Wang, Yong Liu, Deli Zhao, Zhiyi Zhang, Yuqin Liu, Zhe Zhang, Xiangtong Liu, Lixin Tao, Yanxia Luo, Xiaonan Wang, Xinghua Yang, Feng Zhang, Xia Li, Xiuhua Guo
Summary: This study explores the association between altered IgG N-glycosylation and the progression of esophageal squamous cell carcinoma (ESCC), and proposes IgG N-glycosylation and a glycan score as potential predictive markers for ESCC, providing innovative tools for early prevention of esophageal cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Guangcan Chen, Xia Huo, Xiuli Luo, Zhiheng Cheng, Yuling Zhang, Xijin Xu
Summary: Research findings indicate that exposure to polycyclic aromatic hydrocarbon (PAH) pollutants in e-waste areas can significantly impact the intestinal mucosal immunity of children, leading to changes in immune responses such as increased SLA levels, white blood cell counts, decreased CD4(+) T cell percentage, and higher risk of diarrhea. Specific PAH compounds were found to be correlated with different immune markers, with OH-PAH concentrations negatively affecting child growth and certain PAH compounds positively impacting secretory immunoglobulin A levels.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Immunology
Orsolya Oravecz, Roberto Romero, Eszter Toth, Judit Kapitany, Mate Posta, Dahiana M. Gallo, Simona W. Rossi, Adi L. Tarca, Offer Erez, Zoltan Papp, Janos Matko, Nandor Gabor Than, Andrea Balogh
Summary: Galectin-13 and galectin-14 play important immunoregulatory roles during pregnancy by inducing apoptosis of immune cells and promoting cytokine production. These findings provide further understanding of the mechanisms underlying placental immune regulation during a healthy pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Haci Mehmet Kayili, Zidan M. E. Ragoubi, Bekir Salih
Summary: Glycosylation is a crucial post-translational modification that influences cellular events and protein functions. This study developed an integrated stage-tip application for simple and rapid N-glycosylation profiling, reducing analysis time and enabling direct analysis from human plasma.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Food Science & Technology
Jin Zhang, Yirui Chen, Jiaqi Zhang, Yitong Wang, Yanan Liu
Summary: Extra-cellular polysaccharides (EPSs) exhibit excellent immunomodulatory functions, enhancing immune indices of the spleen and thymus significantly. They also have an impact on the release of immune factors.
Article
Biochemistry & Molecular Biology
Ayelet Peres, William D. Lees, Oscar L. Rodriguez, Noah Y. Lee, Pazit Polak, Ronen Hope, Meirav Kedmi, Andrew M. Collins, Mats Ohlin, Steven H. Kleinstein, Corey T. Watson, Gur Yaari
Summary: In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele associated with each T- and B-cell receptor sequence is challenging. In this study, we propose an alternative naming scheme for V alleles and a novel method to infer individual genotypes. We validate the effectiveness of our approach and implement it in a freely available R package (PIgLET).
NUCLEIC ACIDS RESEARCH
(2023)
Article
Peripheral Vascular Disease
Domagoj Kifer, Panayiotis Louca, Ana Cvetko, Helena Deris, Ana Cindric, Harald Grallert, Annette Peters, Ozren Polasek, Olga Gornik, Massimo Mangino, Tim D. Spector, Ana M. Valdes, Sandosh Padmanabhan, Christian Gieger, Gordan Lauc, Cristina Menni
Summary: This study found that the glycome of IgG can change before the onset of hypertension, and four specific glycan traits are predictive of incident hypertension. These findings provide insights into the mechanisms of disease development.
JOURNAL OF HYPERTENSION
(2021)
Article
Fisheries
Ghasem Mohammadi, Mahmoud Hafezieh, Ali Akbar Karimi, Mohamad Nor Azra, Hien Van Doan, Wanaporn Tapingkae, Hisham A. Abdelrahman, Mahmoud A. O. Dawood
Summary: This study evaluated the effects of pistachio hulls derived polysaccharide (PHDP) and Pediococcus acidilactici (PA) separately or as a synbiotic on the growth performance, immune responses, and disease resistance of Nile tilapia. The results showed significantly improved growth performance, immune responses, and disease resistance in fish fed with the synbiotic feed additive compared to the control group.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Satoshi Haga, Yutaka Suzuki, Masafumi Miwa, Kaiyu Kubota, Miki Sakatani
Summary: This study evaluated changes in salivary IgA and IgG concentrations in Japanese Black cows during calving, revealing that salivary IgA concentrations decrease drastically after calving, while IgG concentrations decrease gradually. This is important for understanding maternal immunity in cattle.
ANIMAL SCIENCE JOURNAL
(2022)
Review
Immunology
Marcos Jesse Abrahao Silva, Layana Rufino Ribeiro, Karla Valeria Batista Lima, Luana Nepomuceno Gondim Costa Lima
Summary: Through this study, we can gain a brief overview of the main immunological biomarkers and their function in specific cell types during SARS-CoV-2 infection. In critically ill patients, adaptive immunity is diverse, aberrantly compromised, and appears late. The T-cell response, in particular, is an essential component for immunological memory and should be addressed in vaccine formulation strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Daniel Hirschberg, Bertil Ekman, Jeanette Wahlberg, Eva Landberg
Summary: The study found that patients with hyperprolactinemia have significantly higher levels of galactosylation in IgG1 and IgG2/3, potentially impacting IgG interactions with Fc receptors, complement, and lectins, leading to altered immune response.
Article
Food Science & Technology
Wenqi Cai, Hongyun Zhang, XinRu Chen, Shiyu Yan, Lina Yang, Hong Song, Jun Li, Jun Liu, Hansong Yu, He Liu, Danshi Zhu
Summary: This study investigated the impact of extraction method on the physicochemical and structural properties of soy hull polysaccharide (SHP). The results indicated that the polysaccharide extraction rate and composition varied with different extraction methods, but the main chain composition and molecular weight were similar.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
