期刊
CIRCULATION RESEARCH
卷 122, 期 9, 页码 1221-1237出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.118.310966
关键词
cardiovascular diseases; mass spectrometry; post-translational protein modifications; proteome; proteomics
资金
- Barbara Streisand Women's Heart Center
- Smidt Heart Institute at Cedars Sinai Medical Center
- Erika Glazer Endowed Chair in Women's Heart Health
- [1K99HL128787-01A1]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K99HL128787] Funding Source: NIH RePORTER
There is an exponential increase in biological complexity as initial gene transcripts are spliced, translated into amino acid sequence, and post-translationally modified. Each protein can exist as multiple chemical or sequencespecific proteoforms, and each has the potential to be a critical mediator of a physiological or pathophysiological signaling cascade. Here, we provide an overview of how different proteoforms come about in biological systems and how they are most commonly measured using mass spectrometry-based proteomics and bioinformatics. Our goal is to present this information at a level accessible to every scientist interested in mass spectrometry and its application to proteome profiling. We will specifically discuss recent data linking various protein post-translational modifications to cardiovascular disease and conclude with a discussion for enablement and democratization of proteomics across the cardiovascular and scientific community. The aim is to inform and inspire the readership to explore a larger breadth of proteoform, particularity post-translational modifications, related to their particular areas of expertise in cardiovascular physiology.
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