Article
Pharmacology & Pharmacy
Narin Ozturk, Dilek Ozturk Civelek, Serap Sancar, Engin Kaptan, Zeliha Pala Kara, Alper Okyar
Summary: The study revealed dosing-time dependent testicular toxicity of everolimus in mice, with greater severity when administered at early rest-span (daytime-ZT1) compared to early activity-span (nighttime-ZT13). These findings support the concept of everolimus chronotherapy for minimizing reproductive toxicity and increasing the tolerability of everolimus, providing a clinical advantage.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Pere Fontova, Helena Colom, Raul Rigo-Bonnin, Lisanne N. van Merendonk, Anna Vidal-Alabro, Nuria Montero, Edoardo Melilli, Maria Meneghini, Anna Manonelles, Josep M. Cruzado, Juan Torras, Josep Maria Grinyo, Oriol Bestard, Nuria Lloberas
Summary: The study compared the pharmacokinetic and pharmacodynamic profiles of tacrolimus between morning and night doses, showing significantly lower drug concentrations in whole blood and intracellular compartments after the night dose compared to the morning dose. However, this lower exposure did not translate into a significant reduction in pharmacodynamic effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yoshihiro Seto, Kentaro Niwa, Fumiyasu Okazaki, Hideto To
Summary: Although cisplatin is an important drug in cancer chemotherapy, it often causes sensory peripheral neuropathy, leading to allodynia in the early stage and hypoalgesia in the severe stage. Research has shown that the timing of cisplatin administration affects oxidative stress levels, and severe oxidative stress is associated with cisplatin-induced hypoalgesia. Therefore, chronotherapy with cisplatin may be beneficial for the treatment of cancer in humans.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
C. Matamoros, I. J. Salfer, P. A. Bartell, K. J. Harvatine
Summary: This study investigated the effects of the timing of acetate infusion on peripheral rhythms of milk synthesis and plasma metabolites in dairy cows. The results showed that the timing of acetate infusion can influence the daily rhythms of milk synthesis and plasma metabolites in cows.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Endocrinology & Metabolism
Mariarosaria Negri, Claudia Pivonello, Chiara Simeoli, Gilda Di Gennaro, Mary Anna Venneri, Francesca Sciarra, Rosario Ferrigno, Cristina de Angelis, Emilia Sbardella, Maria Cristina De Martino, Annamaria Colao, Andrea M. Isidori, Rosario Pivonello
Summary: The study found that late-in-the-day cortisol exposure modulates insulin sensitivity-related gene expression and intracellular insulin signaling in skeletal muscle cells.
NEUROENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Mathilde Reyt, Michele Deantoni, Marion Baillet, Alexia Lesoinne, Sophie Laloux, Eric Lambot, Justine Demeuse, Chiara Calaprice, Caroline LeGoff, Fabienne Collette, Gilles Vandewalle, Pierre Maquet, Vincenzo Muto, Gregory Hammad, Christina Schmidt
Summary: This study found an association between daytime rest and 24-hour rest probability profiles, circadian timing, and neurobehavioral outcomes in healthy older adults. The results suggest that increasing daytime rest frequency is related to more fragmented nighttime rest and lower episodic memory performance.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Sandrine Dulong, Lucas Eduardo Botelho de Souza, Jean Machowiak, Benoit Peuteman, Gaelle Duvallet, Deborah Boyenval, Elise Roth, Afag Asgarova, Yunhua Chang, Xiao-Mei Li, Adlen Foudi, Annabelle Ballesta
Summary: This study investigated the sex- and timing-related factors of hematopoietic toxicities induced by oxaliplatin in mice. The results showed that there were significant circadian rhythms in the counts of white blood cells and bone marrow cellularity in both sexes at different time points.
Editorial Material
Biochemistry & Molecular Biology
Christine Merlin
Summary: The molecular mechanism behind organisms' ability to anticipate variations in environmental conditions caused by tides in the intertidal zone has been unknown. A recent study shows that the circadian clock gene bmal1 is necessary for circatidal rhythms.
Review
Oncology
Yasser F. Ali, Zhiqiang Hong, Ning-Ang Liu, Guangming Zhou
Summary: Numerous studies have shown that tumor cells are often not synchronized with the surrounding healthy tissue. Exploiting this mismatch can lead to significant advantages in the therapeutic window. Based on a review of 24 studies, it was found that radiation therapy administered at specific times may result in less toxicity, possibly due to reduced damage to healthy cells. However, there are discrepancies among the studies, calling for further investigation. Mechanistic studies investigating the relationship between radiotherapy, circadian rhythms, and cell cycle, along with the use of digital or biological chronodata, could assist oncologists in effectively classifying individual patients according to their chronotypes and strategizing treatment plans accordingly.
CANCER BIOLOGY & THERAPY
(2022)
Article
Endocrinology & Metabolism
Javiera Cortes-Rios, Maria Rodriguez-Fernandez
Summary: The timing of antihypertensive medications affects the long-term cardiovascular risk of hypertensive individuals. However, the underlying causes and mechanisms of this timing-dependent antihypertensive effect are not yet understood.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Marriam Ali, Sirimon Reutrakul, Gregory Petersen, Kristen L. Knutson
Summary: The timing of eating is associated with metabolic health, with earlier eating start time being associated with lower fasting glucose and estimated insulin resistance. This suggests that meal timing is an important characteristic of dietary patterns that can affect metabolism.
Article
Anesthesiology
M. L. van Zuylen, A. J. G. Meewisse, W. Ten Hoope, W. J. Eshuis, M. W. Hollmann, B. Preckel, S. E. Siegelaar, D. J. Stenvers, J. Hermanides
Summary: This study found peri-operative changes in diurnal sleep-wake patterns in patients undergoing surgery and general anaesthesia, leading to decreased sleep quality and increased daytime fatigue.
Article
Clinical Neurology
Meltem Guemues, Maryam Said, Mehdi Chihi, Thiemo F. Dinger, Jan Rodemerk, Benedikt Frank, Marvin Darkwah Oppong, Philipp Dammann, Karsten H. Wrede, Michael Forsting, Ulrich Sure, Ramazan Jabbarli
Summary: This study analyzes the temporal distribution of aneurysmal subarachnoid hemorrhage (SAH) and explores the impact of socio-demographic and clinical characteristics on the timing of the rupture event. The results show two peaks in the circadian rhythm of SAH, with the strongest alterations observed for weekdays, age, sex, and ethnicity. The study also indicates that the rupture timing has no influence on the severity, complications, and outcome of SAH patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Angela Montaruli, Lucia Castelli, Antonino Mule, Raffaele Scurati, Fabio Esposito, Letizia Galasso, Eliana Roveda
Summary: Circadian rhythm is crucial in regulating key biological functions, with individual chronotypes influencing preferred times for activity and sleep, impacting health differently. Understanding and addressing these differences helps reduce risks of diseases and sleep disorders.
Article
Engineering, Environmental
Tianxu Zhang, Lingyan Zhu, Yumeng Sun, Liping Yang, Shujun Yi, Wenjue Zhong
Summary: As an alternative to traditional per- and polyfluoroalkyl substances (PFAS), perfluoroalkyl phosphonic acids (PFPiAs) can induce pigmentation in Xenopus laevis tadpoles by up-regulating MITF and damaging retinal function, disrupting circadian rhythm. The exposure to 6:6 PFPiA resulted in evident pigmentation, thinner retinal layers, reduced photosensitivity, disturbed circadian rhythm, higher and relatively stable levels of melanin throughout the light/dark cycle, distinct oxidative damage, and significantly increased expression of MITF. Molecular docking analysis suggested that 6:6 PFPiA can directly activate MITF by forming strong interactions in its binding pocket.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Oncology
Ozlem Tufekci, Melike Sezgin Evim, Adalet Meral Gunes, Tiraje Celkan, Deniz Yilmaz Karapinar, Zuhre Kaya, Birsen Baysal, Birol Baytan, Ulker Kocak, Sebnem Yilmaz, Suzan Cinar, Hale Oren
Summary: Assessing minimal residual disease (MRD) is crucial for risk classification and personalized therapy in childhood acute lymphoblastic leukemia (ALL). A study in Turkey retrospectively collected data of pediatric ALL patients treated with Berlin-Frankfurt-Munster (BFM) protocols. MRD assessment was done using real-time quantitative polymerase chain reaction (qPCR) and multiparametric flow cytometry (MFC). MRD monitoring led to upgrading 2% of patients from intermediate risk group to high-risk group. Factors such as age ≥10 years, poor response to prednisone, PCR-MRD ≥10(-3) on day 33 and day 78 were identified as poor prognostic factors affecting event-free survival (EFS). Establishing infrastructure and ensuring standardization for MRD methods are crucial for optimal management of children with ALL.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2022)
Article
Oncology
Ayse Engin, Akif Turna, Fehim Esen, Melek Agkoc, Duygu Ilke Cikman, Omer Faruk Saglam, Gunnur Deniz, Esin Cetin Aktas
Summary: Removal of mediastinal lymph node (MLN) by video-assisted mediastinoscopic lymphadenectomy (VAMLA) improves the phenotype and function of CTLs in patients with non-small cell lung cancer (NSCLC), including reducing immunosenescent cells, decreasing immune checkpoint receptor expression, and enhancing cytotoxicity.
Article
Rheumatology
Selma Sari, Suzan Cinar, Yasemin Yalcinkaya, Bahar Artim-Esen, Yasemin Ozluk, Ahmet Gul, Lale Ocal, Gunnur Deniz, Murat Inanc
Summary: This study aimed to investigate the association between serum B-cell activating factor (BAFF) and A proliferation-inducing ligand (APRIL) levels with disease activity and clinical findings in SLE patients. The results showed that both BAFF and APRIL levels were higher in patients with SLE compared to the control group, but there was no correlation between BAFF/APRIL levels and disease activity scores. Serum BAFF levels were higher in patients with renal disease activity, while APRIL levels were significantly correlated with proteinuria. The study suggests that BAFF can be a valuable biomarker in SLE, especially in patients with renal activity.
Article
Immunology
Zakya Shoub Elshari, Serdar Nepesov, Ilhan Tahrali, Ayca Kiykim, Yildiz Camcioglu, Gunnur Deniz, Umut Can Kucuksezer
Summary: This study investigated and compared mitogen-stimulated proliferation responses of lymphocytes in children and adult healthy donors. The findings revealed similarities between the two age groups, with the only difference being a significantly high proliferation of pediatric CD4(+) T cells in response to PHA. The study also found that the CD4(+) T cell responses against PHA diminished with advancing age in pediatric individuals.
IMMUNOLOGIC RESEARCH
(2023)
Editorial Material
Hematology
Zuhre Kaya, Serap Kirkiz, Suzan Cinar, Ulker Kocak
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2023)
Article
Cell Biology
Neslihan Cabioglu, Esin Cetin Aktas, Selman Emiroglu, Mustafa Tukenmez, Enver Ozkurt, Mahmut Muslumanoglu, Abdullah Igci, Vahit Ozmen, Gunnur Deniz, Ahmet S. Dinccag, Yusuf Guven
Summary: This study evaluated the changes in intracellular cytokine expression patterns in different T-lymphocyte subsets after ozone therapy in patients with refractory idiopathic granulomatous mastitis (IGM). The results showed that ozone therapy stimulated a specific immune response in T cells and downregulated the expression of TGF-β in regulatory T cells. These immune system changes can improve wound healing and restore immune dysfunction in patients with refractory IGM.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Immunology
Burcin Aydin Ozgur, Suzan Adin Cinar, Ender Coskunpinar, Abdullah Yilmaz, Derya Altunkanat, Gunnur Deniz, Ali Osman Gurol, M. Temel Yilmaz
Summary: Th cells are involved in the pathogenesis of type 1 diabetes. CD4(+)CD25(high) cell ratios are reduced in newly diagnosed and 1-year diabetic patients. Additionally, higher Th1/Th2, Th17/Treg, and Th1/Treg ratios are observed in patient groups.
IMMUNOLOGIC RESEARCH
(2023)
Article
Microbiology
Metin Yusuf Gelmez, Kaya Koksalan, Suzan Cinar, Nevin Hatipoglu, Taner Coskuner, Zeynep Topkarci, Selda Hancerli Torun, Asuman Demirbuga, Esra Yucel, Ayca Kiykim, Haluk Cezmi Cokugras, Hatice Betul Gemici-Karaaslan, Yasemin Kendir-Demirkol, Gunnur Deniz
Summary: This study aimed to determine the expression of IFN-gamma R1 and IL-12R beta 1 in patients with MSMD, their relatives, and healthy individuals, and to evaluate the importance of flow cytometry as a fast and reliable method in the diagnosis of MSMD. The results showed that the determination of IL-12R beta 1 and IFN-gamma R1 deficiencies by flow cytometry can be used as a rapid and reliable method for the diagnosis of MSMD.
MIKROBIYOLOJI BULTENI
(2023)
Article
Chemistry, Multidisciplinary
Belma Zengin Kurt, Gulsen Celebi, Dilek Ozturk Civelek, Atilla Akdemir, Andrea Angeli, Fatih Sonmez, Claudiu T. Supuran
Summary: In this study, sixty novel coumarin-monoterpene compounds were synthesized and evaluated for their inhibitory effects on hCA isoforms and anticancer potentials. All synthesized molecules selectively inhibited CA IX and XII, with compounds 23 and 42 showing the strongest inhibitory activity against hCA IX. Cytotoxicity evaluation revealed that compounds 14 and 63 exhibited the highest cytotoxicity on MCF-7 cells, while compound 23 showed the strongest cytotoxic effect on both PC-3 and HT-29 cell lines. Furthermore, compounds 14, 23, and 66 showed a reduction in CA IX and CA XII protein expression and increased apoptosis in different cell lines. The modeling studies demonstrated that only the open coumarin form of the compounds could interact directly with the active-site Zn2+ ion.
Article
Medicine, General & Internal
Amani Alkendi, Metin Yusuf Gelmez, Ilhan Tahrali, Gonul Aydogan, Gunnur Deniz, Suzan Cinar
Summary: Acute lymphoblastic leukemia (ALL) is the most common type of cancer in children, and multidrug resistance is a major obstacle in its treatment. This study investigates the expression of multidrug resistance-related protein 1 (MRP1) in children with B-ALL and compares it with other prognostic factors. The results show that there is no significant difference in MRP1 expression between different risk groups and other prognostic factors such as flow cytometric minimal residual disease (MRD) and DNA index.
Article
Biology
Yasemin Kubra Akyel, Dilek Ozturk Civelek, Narin Ozturk Seyhan, Seref Gul, Isil Gazioglu, Zeliha Pala Kara, Francis Levi, Ibrahim Halil Kavakli, Alper Okyar
Summary: The circadian timing system is responsible for regulating the pharmacokinetics of drugs over a 24-hour period. Understanding the temporal changes in pharmacokinetics is crucial for anticancer drugs with narrow therapeutic ranges and dose-limiting side effects. This study evaluated the diurnal rhythm-dependent metabolism of capecitabine and found that the levels of metabolizing enzymes varied throughout the day, leading to differences in pharmacokinetics. This highlights the importance of considering the administration time of capecitabine to maximize efficacy and minimize adverse effects.
JOURNAL OF BIOLOGICAL RHYTHMS
(2023)
Article
Medicine, Research & Experimental
Ozden Ozcan, Metin Yusuf Gelmez, Suzan Cinar, Gunnur Deniz, Melih Aktan
Summary: In this study, STAT3 and IL-10 levels were investigated in CLL patients. The results showed increased IL-10+CD19+, IL-10+ and STAT3+CD19+ in lymphocytes of patients compared to healthy subjects. The expression of IL-10 was found to be increased in CD19+ B cells of CLL patients, while the expression of STAT3 was lower in patients compared to healthy controls. These findings suggest that the levels of IL-10 and STAT3 expression in CLL B cells differ from normal B lymphocytes and may play a role in the biology of CLL.
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hivda Ulbegi Polat, Irem Abaci, Arzu Tas Ekiz, Ozge Aksoy, Fatma Betul Oktelik, Vuslat Yilmaz, Saban Tekin, Alper Okyar, Oral Oncul, Gunnur Deniz
Summary: The study aimed to determine the antiviral activity of C-Vx against SARS-CoV-2 infection. The results showed that C-Vx provided 90% protection against the virus in K18-hACE2 transgenic mice, demonstrating its antiviral efficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Erkan Civelek, Dilek Ozturk Civelek, Yasemin Kubra Akyel, Deniz Kaleli Durman, Alper Okyar
Summary: The circadian timing system (CTS) is vital for adapting to cyclical changes and regulating energy homeostasis. Adipose tissue plays a crucial role in energy storage and its physiological processes, including circadian rhythm, are associated with metabolic diseases. This review summarizes the current knowledge on circadian rhythmicity in adipose tissue and examines the potential links between alterations in adipose tissue and metabolic diseases, as well as discussing therapeutic approaches and clock genes as potential targets for chronotherapy.
Article
Pharmacology & Pharmacy
Erkan Civelek, Dilek Ozturk Civelek
Summary: The study investigated the role of nitric oxide (NO) in HUVEC cells under inflammatory conditions induced by tumor necrosis factor alpha (TNF-a). The phosphorylation of ERK, Akt, and eNOS was examined to identify TNF-a induction mechanisms. Sildenafil and L-NAME were used to examine the role of NO. The results showed that TNF-a increased nitrite/nitrate production and decreased cell viability, while sildenafil and L-NAME had no effect on cell viability but decreased nitrite/nitrate levels in stimulated HUVEC cells. TNF-a had no effect on the phosphorylation of ERK, Akt, and eNOS, but increased total eNOS levels. Sildenafil and L-NAME had no effect on protein phosphorylation.
JOURNAL OF RESEARCH IN PHARMACY
(2023)