Article
Medicine, General & Internal
Kun Jin, Shi Qiu, Bo Chen, Zilong Zhang, Chichen Zhang, Xianghong Zhou, Lu Yang, Jianzhong Ai, Qiang Wei
Summary: This study aimed to investigate the role and mechanisms of DOK3 in prostate cancer (PCa). The findings showed that DOK3 was up-regulated in PCa tissues and cell lines, and its high expression was predictive of higher pathological stages and worse prognoses. Knocking down DOK3 inhibited cell proliferation and promoted apoptosis by suppressing the activation of the NF-kappa B pathway.
CHINESE MEDICAL JOURNAL
(2023)
Article
Oncology
Yang Lyu, Bowen Duan, Ziming Liu, Fan Yang, Chen Chen, Xuejiao Jiang, Xiang Liu
Summary: This study found that Sparstolonin B inhibits the growth and induces apoptosis of pancreatic cancer cells through the NFxB signaling pathway, making it a potential novel drug for pancreatic cancer treatment.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Chemistry, Medicinal
Xue Han, Jiajia Zhang, Li Zhou, Jiajia Wei, Yu Tu, Qiaojuan Shi, Yi Zhang, Juan Ren, Yi Wang, Huazhong Ying, Guang Liang
Summary: Sclareol may prevent and ameliorate diabetic nephropathy through its anti-inflammatory effects, which involve the regulation of the MAPK/NFKB signaling pathway.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sisi Huang, Kaiyue Wang, Dongyan Huang, Xin Su, Rongfu Yang, Congcong Shao, Juan Jiang, Jianhui Wu
Summary: This study found that lower doses of BPAF can promote dorsal prostatic hyperplasia in rats by interfering with multiple biomarkers in the NF-kappa B signaling pathway. These findings further confirm the toxic effect of BPAF on prostate health and provide important clues to the underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Hongru Lin, Xuehan Wu, Yaqin Yang, Ziwei Wang, Weilu Huang, Ling-Fang Wang, Quan-Wen Liu, Xiao-Hui Guan, Ke-Yu Deng, Tao-Sheng Li, Yisong Qian, Hong-Bo Xin
Summary: Nicaraven effectively inhibits TNF alpha-induced endothelial activation and inflammatory response by suppressing NF-kappa B signaling pathway, thereby improving endothelial cell functions.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Review
Materials Science, Multidisciplinary
Haiyuan Xing, Ruiyan Li, Yun'an Qing, Boda Ying, Yanguo Qin
Summary: Through the study of Osteoimmunomodulation (OIM) and the TLR4-NF-kappa B pathway, it has been found that immune cells play a crucial role in bone integration and healing, leading to a better understanding of the mechanism behind bone regeneration.
APPLIED MATERIALS TODAY
(2021)
Article
Biochemistry & Molecular Biology
Kaiyue Wang, Dongyan Huang, Ping Zhou, Xin Su, Rongfu Yang, Congcong Shao, Aicui Ma, Jianhui Wu
Summary: BPA and BPAF can induce prostatic hyperplasia in rats and modulate the regulation of the NF-kB signaling pathway. In addition, combined exposure to BPA and BPAF can also increase proliferation and reduce apoptosis in human prostate cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eiichi Kusagawa, Chiharu Okuda, Rikako Yamaguchi, Kaori Nakano, Yasunobu Miyake, Takao Kataoka
Summary: Cucurbitacin B down-regulates TNF-alpha-induced ICAM-1 expression and inhibits the inflammatory response in lung adenocarcinoma cells by modulating the TNF-R1 expression in the NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Wenyi Qin, Xiaofeng Rong, Chao Yu, Ping Jia, Juan Yang, Guoqing Zhou
Summary: This study found that the SLAMF8 gene is aberrantly expressed in rheumatoid arthritis (RA) patients and plays an important role in initiating inflammation and maintaining a pro-inflammatory environment. Targeted inhibition of SLAMF8 can attenuate the severity of RA by blocking the TLR4/NF-kappa B signaling pathway. This research provides a new potential target for the treatment of RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Ming Jing, Junjie Yang, Lirong Zhang, Jing Liu, Sen Xu, Meiling Wang, Leiming Zhang, Yue Sun, Weibin Yan, Guige Hou, Chunhua Wang, Wenyu Xin
Summary: The study demonstrates that Celastrol effectively alleviates rheumatoid arthritis (RA) symptoms by inhibiting the activation of the NF-κB signaling pathway and NLRP3 inflammasome, ultimately suppressing inflammation. Celastrol also inhibits ROS production induced by LPS and ATP, suggesting a potential therapeutic mechanism for treating RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Respiratory System
Wei Zhou, Yapeng Hou, Tong Yu, Tingyu Wang, Yan Ding, Hongguang Nie
Summary: This study investigated the effects of hypoxia on the expression of epithelial sodium channel (ENaC) and its associated mechanisms, providing a potential treatment strategy for edema-related pulmonary diseases. The results showed that hypoxia downregulated the protein/mRNA expression of ENaC and activated the ERK/NF-kappa B signaling pathway. Inhibition of this pathway reversed the downregulation of ENaC and alleviated pulmonary edema.
RESPIRATORY RESEARCH
(2023)
Article
Fisheries
Renjie Chang, Weiwei Zheng, Yuena Sun, Tianjun Xu
Summary: This study elucidated the mechanism by which miR-1388-5p regulates the NF-kappa B signaling pathway by targeting the IRAK1 gene, enriching the miRNA-mediated regulatory networks in fish innate immunity.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Linjiang Song, Shaomi Zhu, Chi Liu, Qinxiu Zhang, Xin Liang
Summary: Baicalin is an efficient inhibitor of NF-κB with good anti-tumor effect on colorectal cancer. It triggers mitochondria-mediated apoptosis, inhibits migration, and enhances anti-tumor immunity via the TLR4/NF-κB signaling pathway.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Plant Sciences
In Gyoung Ju, Eugene Huh, Namkwon Kim, Seungmin Lee, Jin Gyu Choi, Jongki Hong, Myung Sook Oh
Summary: This study showed that Artemisiae Iwayomogii Herba (AIH) attenuates neuroinflammation by regulating the NF-kappa B and MAPK pathways, and it may be used for treating neurological diseases. The inhibitory effects of AIH on microglia-mediated neuroinflammation and NLRP3 inflammasome formation were demonstrated both in vitro and in a mouse model.
Article
Biochemistry & Molecular Biology
Eduardo E. Vargas-Pozada, Erika Ramos-Tovar, Juan D. Rodriguez-Callejas, Irina Cardoso-Lezama, Silvia Galindo-Gomez, Daniel Talamas-Lara, Veronica Rocio Vasquez-Garzon, Jaime Arellanes-Robledo, Victor Tsutsumi, Saul Villa-Trevino, Pablo Muriel
Summary: This study evaluated the effect of caffeine on the NLRP3 inflammasome signaling pathway in a rat model of NASH. The findings suggest that caffeine inhibits NLRP3 inflammasome activation by suppressing the TLR4/MAPK/NF-κB signaling pathway, thereby reducing fat accumulation, necrosis, cholestasis, oxidative stress, and fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Dangui Chen, Di Zhou, Jingyan Xu, Rongfu Zhou, Jian Ouyang, Bing Chen
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2019)
Article
Oncology
Dan Guo, Peipei Xu, Chaoyang Guan, Yong Xu, Yonggong Yang, Jingyan Xu, Rongfu Zhou, Bing Chen
Article
Oncology
Peipei Xu, Rongfu Zhou, Jingyan Xu, Jian Ouyang, Xiaoyan Shao, Bing Chen
TRANSLATIONAL CANCER RESEARCH
(2019)
Meeting Abstract
Hematology
Peipei Xu, Guo Dan, Bing Chen, Quan Zhao, Rong-Fu Zhou, Jian Ouyang
Meeting Abstract
Hematology
Rong-Fu Zhou, Wang Jun, Xu Peng, Hui Zeng, Yong Xu, Yueyi Xu, Min Zhou, Peipei Xu, Bing Chen
Article
Hematology
Sha Liu, Rong-fu Zhou, Zhi-bin Jin, Min Wu, Ping-yang Zhang
Article
Hematology
Cuiling Zhang, Haibo Dong, Yipeng Lin, Peipei Xu, Rongfu Zhou, Hui Zeng
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2020)
Article
Oncology
Jing Wang, Min Zhou, Rongfu Zhou, Jingyan Xu, Bing Chen
FRONTIERS IN ONCOLOGY
(2020)
Review
Medicine, General & Internal
Jing Wang, Min Zhou, Jing-Yan Xu, Rong-Fu Zhou, Bing Chen, Yuan Wan
Letter
Hematology
Sha Liu, Ping-yang Zhang, Zhi-bin Jin, Yan-hui Yuan, Min Wu, Rong-fu Zhou
Article
Materials Science, Biomaterials
Peipei Xu, Ying Jiang, Huaqin Zuo, Xu Liu, Tian Xia, Rongfu Zhou, Bing Chen, Jian Ouyang
BIOMATERIALS SCIENCE
(2019)
Article
Medicine, Research & Experimental
Bo Gao, Yu Liu, Rongfu Zhou, Ping Xu, Min Zhou, Yong Xu, Ping Li
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2019)
Review
Medicine, Research & Experimental
Yueyi Xu, Jian Ouyang, Min Zhou, Yong Xu, Ping Li, Xiaoyan Shao, Bing Chen, Rongfu Zhou
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2019)
Meeting Abstract
Hematology
Rong-Fu Zhou, Qian Li, Min Zhou
Meeting Abstract
Hematology
Qian Li, Hui Zeng, Yong Xu, Min Zhou, Bing Chen, Rong-Fu Zhou
