期刊
CHINESE JOURNAL OF POLYMER SCIENCE
卷 36, 期 5, 页码 576-583出版社
SPRINGER
DOI: 10.1007/s10118-018-2032-z
关键词
Antibacterial surface; Metal-phenolic coating; DNA-cleavage; Biomimetic surface
资金
- Jilin University [419080500665, 451170301076]
- Natural Science Foundation of Shandong Province [ZR2015EM036]
Despite the fact that numerous infection-resistant surfaces have been developed to prevent bacterial colonization and biofilm formation, developing a stable, highly antibacterial and easily produced surface remains a technical challenge. As a crucial structural component of biofilm, extracellular DNA (eDNA) can facilitate initial bacterial adhesion, subsequent development, and final maturation. Inspired by the mechanistic pathways of natural enzymes (deoxyribonuclease), here we report a novel antibacterial surface by employing cerium (Ce(IV)) ion to mimic the DNA-cleavage ability of natural enzymes. In this process, the coordination chemistry of plant polyphenols and metal ions was exploited to create an in situ metal-phenolic film on substrate surfaces. Tannic acid (TA) works as an essential scaffold and Ce(IV) ion acts as both a cross-linker and a destructor of eDNA. The Ce(IV)-TA modified surface exhibited highly enhanced bacteria repellency and biofilm inhibition when compared with those of pristine or Fe(III)-TA modified samples. Moreover, the easily produced coatings showed high stability under physiological conditions and had nontoxicity to cells for prolonged periods of time. This as-prepared DNA-cleavage surface presents versatile and promising performances to combat biomaterial-associated infections.
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