Article
Biochemistry & Molecular Biology
Anna Baranska, Paulina Sicinska, Jaromir Michalowicz
Summary: This study found that 2,4,6-TBP and PBP can induce apoptosis in human PBMCs and have effects on multiple parameters of the cells. The mitochondrial pathway plays a major role in the apoptosis process of PBMCs exposed to these substances.
Article
Biochemistry & Molecular Biology
Anna Baranska, Bozena Bukowska, Jaromir Michalowicz
Summary: The study found that both TBBPA and TBBPS can induce apoptosis in human leukocytes, primarily through the mitochondrial pathway.
Article
Environmental Sciences
Shanshan Hou, Xiayu Zhang, Xiaofan Ning, Hao Wu, Xinyue Li, Kai Ma, Huifang Hao, Chunping Lv, Chunrui Li, Zhongjun Du, Haiying Du, Minghua Jin
Summary: This study explores the role of ROS-mediated PARP/AIF apoptosis signaling pathway in MeHg-induced cell death. The results suggest that increased levels of ROS and calcium ion, as well as the activation of caspase cascades and PARP, are involved in MeHg-induced apoptosis. The inhibition of ROS production can reduce the apoptosis rate. The PARP/AIF apoptotic pathway is independent of the caspase pathway and regulates it.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Tayyebeh Ghaffari, Solmaz Asnaashari, Ebrahim Irannejad, Abbas Delazar, Safar Farajnia, Joo-Hyun Hong, Changhyun Pang, Hamed Hamishehkar, Ki Hyun Kim
Summary: The study revealed that extracts from Pinus eldarica possess inhibitory effects on human lung cancer A549 cells, with pollen hexane extract, bark essential oil, and methanolic needle extract showing superior results. These extracts induced apoptosis, inhibited cell proliferation, and affected cell cycle progression, suggesting their potential as new therapeutic agents for lung cancer.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Md Ezazul Haque, Shofiul Azam, Mahbuba Akther, Duk-Yeon Cho, In-Su Kim, Dong-Kug Choi
Summary: The proton-activated G protein-coupled receptor 4 (GPR4) plays a role in protecting dopaminergic neurons in a mouse model of Parkinson's disease. The GPR4 antagonist NE52-QQ57 shows potential therapeutic benefits by reducing neuronal loss and improving motor and memory functions in MPTP-treated mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Waseem El-Huneidi, Khuloud Bajbouj, Jibran Sualeh Muhammad, Arya Vinod, Jasmin Shafarin, Ghalia Khoder, Mohamed A. Saleh, Jalal Taneera, Eman Abu-Gharbieh
Summary: Carnosic acid inhibits proliferation and survival of human gastric cancer cells in a dose-dependent manner by suppressing the phosphorylation/activation of Akt and mTOR, and enhancing cleavage of PARP as well as downregulating survivin expression.
Article
Medicine, Research & Experimental
Xiaowei Xing, Shuang Guo, Yusheng Liu, Jiangying Kuang, Zhiwei Huang, Xin Wang, Qinghua Lu
Summary: SAX shows potential therapeutic effects in diabetic nephropathy by reducing renal cell apoptosis and pathological outcomes, likely through downregulating the expression of caspase 3 and PARP-1 in the apoptosis pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Trinh Hua, Melanie Robitaille, Sarah J. Roberts-Thomson, Gregory R. Monteith
Summary: Apoptosis is a complex and regulated cell death pathway, and calcium signaling plays a crucial role in its regulation. The initiation and execution of apoptosis are controlled by different groups of cysteine proteases, including caspases, calpains, and cathepsins. Evading apoptosis is a hallmark of cancer cells, which can be achieved through deregulation of cysteine proteases and remodeling of calcium signaling. This review explores the involvement of calcium in the regulation of cysteine protease activity and its impact on intracellular calcium handling during apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Food Science & Technology
Hyeon-Ju Lee, Se-Young Oh, Inho Jo
Summary: This study found that Zearalenone induces endothelial cell apoptosis through activation of an ERK1/2/p53/caspase 3 signaling pathway via release of Ca2+ from the endoplasmic reticulum, independent of reactive oxygen species production and estrogen receptor activation.
Article
Endocrinology & Metabolism
Mohammed Al Dubayee, Awad Alshahrani, Dana Aljada, Mahmoud Zahra, Ahmed Alotaibi, Ibrahim Ababtain, Malik Alnaim, Ali Alahmari, Abdullah Aljarallah, Muhammad Affan Elahi, Hana M. A. Fakhoury
Summary: Insulin resistance in obesity and T2DM is associated with cardiovascular complications such as atherosclerosis, with reduced apoptosis in macrophages linked to accelerated atherosclerosis. This study found changes in apoptosis-related gene expression in PBMCs of diabetic individuals, with metformin treatment significantly inhibiting the expression of some apoptosis-related proteins and upregulating the Bad/Bax/caspase-7 apoptotic pathway. Further research is needed to elucidate the apoptotic pathways in PBMCs of T2DM patients and following metformin treatment.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Md. Selim Hossain, Vijay Sankar Ramasamy, Il-Seon Park
Summary: In this study, the cytotoxic signal transduction pathway related to the increase in cytoplasmic calcium concentration (CCC) induced by Amyloid-beta (A beta) peptide in Alzheimer's disease was explored. The results showed that A beta 42 induces an increase in CCC and this increase is an upstream event of cytotoxic processes. Additionally, it was found that A beta 42 induces a specific cytotoxic pathway involving AILF via increased CCC.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Food Science & Technology
David S. Dang, Chandler D. Stafford, Mackenzie J. Taylor, Jared F. Buhler, Kara J. Thornton, Sulaiman K. Matarneh
Summary: The study found that ultrasonication improved beef tenderness by increasing the activities of calpain-1 and caspase-3. These effects may be achieved by increasing cytosolic calcium and inducing mitochondrial dysfunction.
Article
Immunology
Suji Kim, Hyun-Eui Park, Woo Bin Park, Seo Yihl Kim, Hong-Tae Park, Han Sang Yoo
Summary: The study investigated the host immune response against Mycobacterium avium in dogs, revealing that different immune responses are triggered at different time points after infection. Early induction of Th1-associated genes was observed, followed by an increase in Th17-associated genes. Additionally, a decrease in apoptosis-related gene expression and an increase in intracellular M. avium abundance were observed in monocyte-derived macrophages after 24 hours of infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Rui Miao, Cong Jiang, Winston Y. Chang, Haiwei Zhang, Jinsu An, Felicia Ho, Pengcheng Chen, Han Zhang, Caroline Junqueira, Dulguun Amgalan, Felix G. Liang, Junbing Zhang, Charles L. Evavold, Iva Hafner-Bratkovic, Zhibin Zhang, Pietro Fontana, Shiyu Xia, Markus Waldeck-Weiermair, Youdong Pan, Thomas Michel, Liron Bar-Peled, Hao Wu, Jonathan C. Kagan, Richard N. Kitsis, Peng Zhang, Xing Liu, Judy Lieberman
Summary: Gasdermin D (GSDMD)-activated inflammatory cell death causes mitochondrial damage, leading to reduced mitochondrial numbers, mitophagy, ROS, loss of transmembrane potential, attenuated oxidative phosphorylation (OXPHOS), and release of mitochondrial proteins and DNA. Mitochondrial damage occurs independently of the B-cell lymphoma 2 family and depends on the binding of GSDMD-NT to cardiolipin. Cardiolipin synthase and scramblase play a role in suppressing inflammasome activation and mitochondrial damage.
Article
Chemistry, Physical
Wei Guo, Jing Chang, Shuo Wang, Qingxia Liu, Haijun Zhang
Summary: The presence of Ca2+/ Mg2+ affects the surface potential of minerals during flotation, but the specific adsorption mechanism on different crystal planes is not fully understood. Using the DLVO model, the surface potential of scheelite (112) and (001) surfaces at pH 8 and 11 under the effect of Ca2+/Mg2+ was determined. It was found that increasing Ca2+/Mg2+ concentration made the (112) surface less negative. Charge reversal occurred at pH 11 with 1 mM Mg2+, indicating specific adsorption of MgOH+ on the scheelite (112) surface. However, the (001) surface showed inert adsorption towards Ca2+/ Mg2+ at pH 8 and 11. Understanding the adsorption mechanisms on different crystal planes can help design a more efficient flotation process for scheelite.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Food Science & Technology
Marta Kwiatkowska, Jaromir Michalowicz, Pawel Jarosiewicz, Daria Pingot, Paulina Sicinska, Bogumila Huras, Jerzy Zakrzewski, Monika Jarosiewicz, Bozena Bukowska
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Toxicology
Ewelina Wozniak, Edyta Reszka, Ewa Jablonska, Katarzyna Mokra, Aneta Balcerczyk, Bogumila Huras, Jerzy Zakrzewski, Bozena Bukowska
TOXICOLOGY IN VITRO
(2020)
Article
Environmental Sciences
Anna Wluka, Agnieszka Wozniak, Ewelina Wozniak, Jaromir Michalowicz
Article
Multidisciplinary Sciences
Paulina Sicinska, Katarzyna Mokra, Katarzyna Wozniak, Jaromir Michalowicz, Bozena Bukowska
Summary: The study demonstrates that phthalates and their metabolites can induce DNA damage and oxidative stress, with parent phthalates DBP and BBP causing more pronounced DNA damage compared to their metabolites.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Katarzyna Mokra
Summary: Endocrine disruptors are chemical compounds that cause hormonal imbalance in the body even at low concentrations, leading to various harmful health disorders. PFASs, particularly long- and short-chain variants, have gained significant attention due to their long-lasting presence in the human body and environment, potentially causing short- and long-term health effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ewelina Wozniak, Edyta Reszka, Ewa Jablonska, Jaromir Michalowicz, Bogumila Huras, Bozena Bukowska
Summary: The research found that glyphosate and AMPA can alter the expression of genes related to chromatin structure in human PBMCs, with glyphosate affecting multiple genes and showing a stronger effect at lower concentrations compared to AMPA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Piotr Duchnowicz, Radoslaw Pilarski, Jaromir Michalowicz, Bozena Bukowska
Summary: Extracts from Uncaria tomentosa affect the morphology and membrane properties of human erythrocytes. The compounds mainly incorporate into the outer hydrophilic monolayer of the erythrocyte membrane, providing protection against oxidative stress.
Review
Environmental Sciences
Jaromir Michalowicz, Anna Wluka, Bozena Bukowska
Summary: This review focuses on the sources and impact of three commonly used brominated phenols in the industry, as well as their toxicity and transformation processes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Bozena Bukowska, Katarzyna Mokra, Jaromir Michalowicz
Summary: Benzo[a]pyrene (B[a]P) is a representative polycyclic aromatic hydrocarbon (PAH) that is commonly found in the environment and human surroundings. It has been shown to have toxic effects on DNA, reproduction, neurology, and development. The metabolism of B[a]P is mediated by cytochrome P450 (CYP P450) and its polymorphism determines the sensitivity to B[a]P. Additionally, B[a]P may facilitate the replication of viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anna Baranska, Paulina Sicinska, Jaromir Michalowicz
Summary: This study found that 2,4,6-TBP and PBP can induce apoptosis in human PBMCs and have effects on multiple parameters of the cells. The mitochondrial pathway plays a major role in the apoptosis process of PBMCs exposed to these substances.
Review
Environmental Sciences
Bozena Bukowska, Ewelina Wozniak, Paulina Sicinska, Katarzyna Mokra, Jaromir Michalowicz
Summary: Glyphosate has been shown to induce epigenetic changes that may be associated with carcinogenesis. These changes include alterations in DNA methylation, gene expression, chromatin structure, and the regulation of non-coding RNA molecules. These epigenetic changes can persist over time and be passed on to future generations, potentially leading to the development of diseases such as prostate disease or obesity. More research is needed to fully understand the metabolic effects of these changes on organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biology
Arnau Llobet Rosell, Maria Paglione, Jonathan Gilley, Magdalena Kocia, Giulia Perillo, Massimiliano Gasparrini, Lucia Cialabrini, Nadia Raffaelli, Carlo Angeletti, Giuseppe Orsomando, Pei-Hsuan Wu, Michael P. Coleman, Andrea Loreto, Lukas Jakob Neukomm
Summary: This study demonstrates the critical role of NMN in neurodegeneration in flies, beyond axonal injury, by successfully preserving severed axons through lowering NMN levels.
Article
Biochemistry & Molecular Biology
Anna Baranska, Bozena Bukowska, Jaromir Michalowicz
Summary: The study found that both TBBPA and TBBPS can induce apoptosis in human leukocytes, primarily through the mitochondrial pathway.