Review
Pharmacology & Pharmacy
Chiara Ferraris, Clara Rimicci, Sara Garelli, Elena Ugazio, Luigi Battaglia
Summary: Nanosystems have various cosmetic functions and properties being widely used in the global market. However, safety concerns and regulatory landscape still need to be considered. The European context shows the most restrictive regulations and main safety concerns regarding nanomaterials.
Article
Environmental Sciences
Chusheng Liu, Yanjing Wang, Gaofei Zhang, Xuebin Pang, Jiao Yan, Xiaoou Wu, Yingheng Qiu, Ping Wang, Houshuang Huang, Xiaowei Wang, Haiyuan Zhang
Summary: This study discovered various shapes of gold nanomaterials in commercial cosmetics and investigated their toxicity on the skin, finding that embedding these materials in cosmetics can alleviate their toxic effects.
Article
Chemistry, Physical
Lucia Salvioni, Lucia Morelli, Evelyn Ochoa, Massimo Labra, Luisa Fiandra, Luca Palugan, Davide Prosperi, Miriam Colombo
Summary: The role of cosmetic products in society is evolving rapidly, with the importance of personal wellness contributing to their increasing use. This necessitates a detailed explanation of the use of nanoparticles in cosmetics. Nanotechnology has been shown to improve the performance of cosmetics in various ways, particularly in skincare, and despite concerns about nanoparticle toxicity, there are detailed examples of nanocosmetic products with investigated safety.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, M. A. Cancellieri, H. Chon, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
Summary: The safety assessment supports the use of this material. Evaluations on various aspects of 3-methoxy-5-cresol indicate low risks in terms of genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Medicine, Legal
Ulrike Bernauer, Laurent Bodin, Qasim Chaudhry, Pieter Jan Coenraads, Maria Dusinska, Eric Gaffet, Eirini Panteri, Vera Rogiers, Christophe Rousselle, Maciej Stepnik, Tamara Vanhaecke, Susan Wijnhoven, Natalie von Goetz, Wim H. de Jong
Summary: The European Commission regulates the risk of nanomaterials in cosmetic products through SCCS scientific opinions, focusing on identifying safety concerns and prioritizing nanomaterials for assessment. SCCS advises on key aspects of nanomaterial safety and revisits previous inconclusive opinions to ensure consumer safety.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Review
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. A. Cancellieri, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
Summary: The assessment on citronellyl acetate indicates low risk in terms of genotoxicity, repeated dose toxicity, and reproductive toxicity, while also meeting environmental safety standards.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. A. Cancellieri, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
Summary: The existing data supports the use of alpha-cyclohexylidene benzeneacetonitrile in safety assessment for various aspects. The material is not genotoxic and shows a Margin of Exposure (MOE) > 100 for repeated dose toxicity and reproductive toxicity. Additionally, it is found to have a No Expected Sensitization Induction Level (NESIL) for skin sensitization and is not expected to be phototoxic/ photoallergenic.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Yoonjung Huh, Do-Hyeon Lee, Dalwoong Choi, Kyung-Min Lim
Summary: This study investigated the dermal permeation profiles of 1,2-Benzisothiazolin-3-one (BIT) and assessed its safety for dermal use. The results showed that BIT can permeate the skin quickly, but its amount in the stratum corneum and skin deposit is reduced. The risk assessment based on skin absorption rate indicated that BIT is safe for use in dermally exposed consumer products.
Review
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. A. Cancellieri, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
Summary: The compound 2-cyclohexylidene-2-o-tolylacetonitrile has shown non-genotoxic properties and a calculated Margin of Exposure (MOE) > 100 for repeated dose toxicity and reproductive toxicity. It is considered a skin sensitizer with a No Expected Sensitization Induction Level (NESIL) of 1200 μg/cm². Phototoxicity/photoallergenicity is not expected, and its environmental impact is deemed to be low based on the risk quotients.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. A. Cancellieri, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I. Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
Summary: Based on the evaluation of various endpoints, data show that 2,6-nonadienenitrile does not pose any safety concerns for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Jr Jr Burton, M. A. Cancellieri, H. Chon, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
Summary: Based on various toxicity tests and environmental safety assessments, isodecyl acetate is determined to be safe for use at the declared levels, as it does not present genotoxicity, repeated dose toxicity, reproductive toxicity, phototoxicity/photoallergenicity, or skin sensitization concerns. The substance is also found to have low environmental risk quotients.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. A. Cancellieri, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
Summary: The safety assessment of carvyl acetate indicates that it is not toxic in various aspects, such as genotoxicity. The skin sensitization data show a No Expected Sensitization Induction Level of 550 mu g/cm(2) for carvyl acetate. The environmental evaluation reveals that carvyl acetate is not Persistent, Bioaccumulative, and Toxic.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, M. A. Cancellieri, H. Chon, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
Summary: This safety assessment confirms that methyl propionate has no safety concerns in terms of genotoxicity, repeated dose toxicity, reproductive toxicity, skin sensitization, and environmental safety. Data from analogs also support the lack of adverse effects on health and the environment.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. A. Cancellieri, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
Summary: The safety assessment supports the use of citronellyl butyrate in various aspects such as genotoxicity, repeated dose toxicity, reproductive toxicity, and skin sensitization. It also meets environmental standards and is not persistent, bioaccumulative, or toxic.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, M. A. Cancellieri, H. Chon, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
Summary: Based on the safety assessment, the existing information supports the use of carvyl propionate in various aspects such as genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
