期刊
CHINESE CHEMICAL LETTERS
卷 29, 期 1, 页码 127-130出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2017.07.006
关键词
Chalcone derivatives; 6-Chloro-purine; Antiviral activity; Cucumber mosaic virus; Tobacco mosaic virus; Interaction mechanisms
资金
- National Natural Science Foundation of China [21562013, 21362004]
- Subsidy Project for Outstanding Key Laboratory of Guizhou Province in China [20154004]
- Provincial University Cooperation Plan of Guizhou Province in China [20147001]
- Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan
A series of novel chalcone derivatives containing purine moiety was designed and synthesized, and their antiviral activities against cucumber mosaic virus (CMV) and tobacco mosaic virus (TMV) were evaluated in vivo. Bioactivity assays indicated that some compounds showed good antiviral activities against CMV and TMV. It is worth mentioning that compounds 3o, 3s, 3w, and 3x exhibited excellent curative activity against CMV, with EC50 values of 301.1 mu g/mL, 315.7 mu g/mL, 282.3 mu g/mL, 230.5 mu g/mL, respectively, which were better than that of Dufulin (373.7 mu g/mL) and Ribavirin (726.3 mu g/mL). In addition, the fluorescence spectroscopy experiment results showed that compound 3o showed strong combining capacity to tobacco mosaic virus coat protein. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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