Expanding the SAR of Nontoxic Antiplasmodial Indolyl-3-ethanone Ethers and Thioethers

Emergence of Indigenous Artemisinin-Resistant Plasmodium falciparum in Africa

(2017) Feng Lu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unexpected transformations of 3-(bromoacetyl)coumarin provides new evidence for the mechanism of thiol mediated dehalogenation of α-halocarbonyls

(2017) Faith N. Magwenzi et al.   TETRAHEDRON LETTERS

6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis

(2017) Amy S. T. Tong et al.   ACS Medicinal Chemistry Letters

Indolyl-3-ethanone-α-thioethers: A promising new class of non-toxic antimalarial agents

(2016) Archibald L. Svogie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Genotypic and Phenotypic Stability of Plasmodium falciparum Field Isolates in Continuous In Vitro Culture

(2016) Redemptah Yeda et al.   PLoS One

Variation in susceptibility of African Plasmodium falciparum malaria parasites to TEP1 mediated killing in Anopheles gambiae mosquitoes

(2016) Maarten Eldering et al.   Scientific Reports

Discovery of Inhibitors ofTrypanosoma bruceiby Phenotypic Screening of a Focused Protein Kinase Library

(2015) Andrew Woodland et al.   ChemMedChem

Facile synthesis and biological evaluation of assorted indolyl-3-amides and esters from a single, stable carbonyl nitrile intermediate

(2015) Clinton G.L. Veale et al.   TETRAHEDRON LETTERS

Multi-target pharmacology: possibilities and limitations of the “skeleton key approach” from a medicinal chemist perspective

(2015) Alan Talevi   Frontiers in Pharmacology

Functional Analysis of Sirtuin Genes in Multiple Plasmodium falciparum Strains

(2015) Catherine J. Merrick et al.   PLoS One

Synthetic indole and melatonin derivatives exhibit antimalarial activity on the cell cycle of the human malaria parasite Plasmodium falciparum

(2014) Desirée C. Schuck et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors

(2014) Shailesh N. Mistry et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-Aryl-2-aminobenzimidazoles: Novel, Efficacious, Antimalarial Lead Compounds

(2014) Sreekanth Ramachandran et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Analogues of the Marine Bisindole Deoxytopsentin: Potent Selective Inhibitors of MRSA Pyruvate Kinase

(2014) Clinton G. L. Veale et al.   JOURNAL OF NATURAL PRODUCTS

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis and MRSA PK inhibitory activity of thiazole containing deoxytopsentin analogues

(2014) Clinton G.L. Veale et al.   TETRAHEDRON

Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

(2013) Heike Schönherr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Drug Discovery for Neglected Diseases: Molecular Target-Based and Phenotypic Approaches

(2013) Ian H. Gilbert   JOURNAL OF MEDICINAL CHEMISTRY

Approaches to Protozoan Drug Discovery: Phenotypic Screening

(2013) Melissa L. Sykes et al.   JOURNAL OF MEDICINAL CHEMISTRY

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

(2012) Rainer Wilcken et al.   JOURNAL OF MEDICINAL CHEMISTRY

Melatonin and IP3-induced Ca2+Release from Intracellular Stores in the Malaria ParasitePlasmodium falciparumwithin Infected Red Blood Cells

(2010) Eduardo Alves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

(2010) Fraser F. Fleming et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Synthesis of chalcones and flavanones using Julia–Kocienski olefination

(2010) Atul Kumar et al.   TETRAHEDRON