Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA
出版年份 2018 全文链接
标题
Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis
InhA
作者
关键词
-
出版物
ChemMedChem
Volume 13, Issue 7, Pages 672-677
出版商
Wiley
发表日期
2018-02-05
DOI
10.1002/cmdc.201700774
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- An algorithm to identify functional groups in organic molecules
- (2017) Peter Ertl Journal of Cheminformatics
- N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-transEnoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity
- (2016) Ana Guardia et al. ChemMedChem
- When Does Chemical Elaboration Induce a Ligand To Change Its Binding Mode?
- (2016) Shipra Malhotra et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor
- (2016) Renato Ferreira de Freitas et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach
- (2016) Chao Chen et al. ACS Medicinal Chemistry Letters
- Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor
- (2016) María Martínez-Hoyos et al. EBioMedicine
- Current kinase inhibitors cover a tiny fraction of fragment space
- (2015) Hongtao Zhao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Slow-Onset Inhibition of Mycobacterium tuberculosis InhA: Revealing Molecular Determinants of Residence Time by MD Simulations
- (2015) Benjamin Merget et al. PLoS One
- Direct inhibitors of InhA are active against Mycobacterium tuberculosis
- (2015) U. H. Manjunatha et al. Science Translational Medicine
- Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA
- (2014) Lourdes Encinas et al. JOURNAL OF MEDICINAL CHEMISTRY
- The role of ligand efficiency metrics in drug discovery
- (2014) Andrew L. Hopkins et al. NATURE REVIEWS DRUG DISCOVERY
- Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase
- (2014) Christopher N. Johnson et al. ACS Medicinal Chemistry Letters
- Fragment-based hit identification: thinking in 3D
- (2013) Andrew D. Morley et al. DRUG DISCOVERY TODAY
- Methyl-Thiazoles: A Novel Mode of Inhibition with the Potential to Develop Novel Inhibitors Targeting InhA in Mycobacterium tuberculosis
- (2013) Pravin S. Shirude et al. JOURNAL OF MEDICINAL CHEMISTRY
- Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein–Protein Interactions?
- (2013) David M. Dias et al. ACS Medicinal Chemistry Letters
- Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface
- (2012) Inge Van Molle et al. CHEMISTRY & BIOLOGY
- Targeting InhA, the FASII Enoyl-ACP Reductase: SAR Studies on Novel Inhibitor Scaffolds
- (2012) Pan Pan et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Molecular complexity and fragment-based drug discovery: ten years on
- (2011) Andrew R Leach et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs
- (2011) P. E. Almeida Da Silva et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Deconstruction of Non-Nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1 for Exploration of the Optimization Landscape of Fragments
- (2011) Peter Brandt et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Structure–Activity Relationships of 4-Pyridones as Potential Antimalarials
- (2008) Clive L. Yeates et al. JOURNAL OF MEDICINAL CHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now