期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 14, 页码 3345-3353出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201705335
关键词
antitumor agents; bioinorganic chemistry; heterometallic complexes; luminescence; theranosis
资金
- Ministerio de Economia y Competitividad [MINECO-FEDER CTQ2016-75816-C2-1-P, CTQ2015-70371-REDT]
- Gobierno de Aragon-Fondo Social Europeo [E77]
The design of more efficient anticancer drugs requires a deeper understanding of their biodistribution and mechanism of action. Cell imaging agents could help to gain insight into biological processes and, consequently, the best strategy for attaining suitable scaffolds in which both biological and imaging properties are maximized. A new concept arises in this field that is the combination of two metal fragments as collaborative partners to provide the precise emissive properties to visualize the cell as well as the optimum cytotoxic activity to build more potent and selective chemotherapeutic agents.
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