Article
Chemistry, Physical
Liya Dai, Pengyao Xing, Aiyou Hao
Summary: In this study, the aryl-group achiral molecular tweezers were found to effectively include chiral guest molecules via halogen bonding and other noncovalent interactions. Experimental and computational calculations revealed the formation of stable 1:1 host-guest complexes, demonstrating the transfer of chirality to achiral host molecules at the supramolecular level.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Huaqiang Ju, Chao Nan Zhu, Hu Wang, Zachariah A. Page, Zi Liang Wu, Jonathan L. Sessler, Feihe Huang
Summary: This study introduces a stimuli-responsive invisible ink for time-dependent encryption of information, which displays time-dependent photochromic behavior with tailorable fading rates by controlling the density of host-guest crosslinks. Encryption security of information is achieved through selectively placing host and guest competitors and UV patterning, providing an initially false image that gradually reveals the encrypted data.
ADVANCED MATERIALS
(2022)
Letter
Chemistry, Multidisciplinary
Ahmed Shaukat, Eduardo Anaya-Plaza, Ngong Kodiah Beyeh, Mauri A. A. Kostiainen
Summary: Our recent publication in Chem. Eur. J. 2022, 28, e202104341 has prompted Prof. Peter B. Crowley (P.C.) to question the concept of electrostatic self-assembly. We address the criticism regarding the role of cationic pillar[5]arene macrocycle and provide NMR evidence proving its incorporation into the frameworks. Additionally, we clarify the role of electrostatic interactions and discuss our ferritin-related research in greater detail.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
I Pisagatti, D. Crisafulli, A. Pappalardo, G. Trusso Sfrazzetto, A. Notti, F. Nastasi, M. F. Parisi, N. Micali, G. Gattuso, V. Villari
Summary: A pillar[5]arene was synthesized and found to form a host-guest complex with a viologen derivative, resulting in the quenching of fluorescence intensity through a photoinduced electron transfer process.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Chenghao Hou, Lijing Liu, Siyang Meng, Yue Wu, Meiran Xie, Yongkui Shan, Pingang He, Pengfei Sun, Xiaojuan Liao
Summary: By constructing pillar[5]arene/silica hybrid vesicles, which combine the high strength of silica and the unique molecular recognition of pillar[5]arene, the pH-triggered release behavior can be tuned and more RhB-C6 can be loaded and released slowly.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Raghu Pradeep Narayanan, Abhay Prasad, Alex Buchberger, Lei Zou, Julio Bernal-Chanchavac, Tara Macculloch, Nour Eddine Fahmi, Hao Yan, Fei Zhang, Matthew J. Webber, Nicholas Stephanopoulos
Summary: The combination of multiple orthogonal interactions enables hierarchical complexity in self-assembled nanoscale materials. This study demonstrates the efficient supramolecular polymerization of DNA origami nanostructures using a multivalent display of small molecule host-guest interactions, and exploits high-affinity CB[7]-adamantane interactions to enable responsive enzymatic actuation.
Article
Chemistry, Physical
Susama Chakraborty, Ankana Karmakar, Suraj Mandal, Tamal Goswami, Pranab Ghosh, Amitava Mandal
Summary: The present study focuses on the supramolecular host-guest complexation of OCASP into b-CD, resulting in a thermoresponsive nanotubular architecture. The inclusion complex was characterized using various techniques, and the formation of nanotubes was observed. The reversible switching of assembly and disassembly of the system was demonstrated by temperature changes. Hydrophobic interactions were identified as the main driving force behind the hierarchical structure formation, as confirmed by control experiments. Molecular dynamics simulations further elucidated the stepwise formation process of this hierarchy. This stimuli-responsive system has the potential to tailor its physical properties and contribute to the fabrication of novel smart materials.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Xuejiao Yang, Bihan Wu, Jiong Zhou, Honglei Lu, Hongyue Zhang, Feihe Huang, Huaimin Wang
Summary: This study demonstrates that host-guest complexation can efficiently regulate enzymatic self-assembly, leading to controlled cancer cell death.
Article
Chemistry, Physical
Tobias Dwyer, Timothy C. Moore, Joshua A. Anderson, Sharon C. Glotzer
Summary: Entropy compartmentalization provides new self-assembly routes to colloidal host-guest structures. By modifying the shape of guest particles, a variety of crystal structures and pore motifs can be formed when mixed with star-shaped host particles. The assembly is driven by entropy compartmentalization, with different contributions from the host and guest particles to the free energy of the system.
Article
Chemistry, Physical
Tobias Dwyer, Timothy C. Moore, Joshua A. Anderson, Sharon C. Glotzer
Summary: Entropy compartmentalization provides a new self-assembly route for colloidal host-guest (HG) structures. Leveraging host particle shape has been recently proposed and demonstrated for the assembly of HG structures. However, the influence of guest particles on the porous network structure of host particles has not been explored.
Article
Crystallography
Nucharee Chongboriboon, Kodchakorn Samakun, Winya Dungkaew, Filip Kielar, Mongkol Sukwattanasinitt, Kittipong Chainok
Summary: Halogen bonding is capable of self-assembly and recognition processes in both solution and solid phase. Different types of solvents lead to different supramolecular assemblies, and the strength of the halogen bond depends on the type of hydrogen bond.
Article
Biochemistry & Molecular Biology
S. Soltani, R. Emadi, S. Haghjoo Javanmard, M. Kharaziha, A. Rahmati
Summary: The study developed a novel nanohybrid shear-thinning hydrogel with fast gelation and variable mechanical and biological properties through self-assembly and crosslinking processes. By controlling macromere concentration and host-guest ratio, the rheological and mechanical properties of hydrogels can be modulated, affecting crosslinking density and network structure. The designed nanohybrid hydrogel exhibited excellent durability and biocompatibility based on the specified parameters.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Multidisciplinary
Yutong Li, Jia Wen, Jiangshan Li, Zejia Wu, Wei Li, Kui Yang
Summary: Pillar[ n]arene, as a novel synthetic supra-molecular macrocyclic host, shows great potential for diverse applications due to its rigid structure, facile synthesis, ease of functionalization, and outstanding host-guest chemistry, especially in the field of chemosensing and imaging. Its unique advantages in guest-host recognition mechanisms contribute to its significant roles and advantages in chemosensing and imaging.
Review
Chemistry, Physical
Weilin Qi, Cheng Ma, Yun Yan, Jianbin Huang
Summary: Chiral materials, particularly cyclodextrins, have gained attention in recent years for their potential in supramolecular chirality manipulation. By applying Harata Kodaka's rule to natural cyclodextrins, chirality inversion materials can be easily created through crystalline self-assembly in an environmentally friendly manner. The future outlook on the rapid development of theory and application in this area is promising.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Article
Chemistry, Physical
Shanchao Tan, Hongyu Shi, Xin Du, Kunpeng Wang, Haijun Xu, Junhua Wan, Ke Deng, Qingdao Zeng, Yuhong Liu
Summary: Controlling friction by the electric field is a promising approach to improve the tribological performance. This study demonstrates the effective control of assembly structure and microscale superlubricity of a host-guest assembly using the electric field. The assembly behaviors of fullerene derivatives at different probe biases are characterized using STM and DFT techniques, and the controllability of the friction coefficient is confirmed by AFM. The insights gained from this research not only contribute to the understanding of the host-guest assembly mechanism controlled by the electric field, but also promote the application of fullerene in MEMS.
Article
Chemistry, Multidisciplinary
Zheng-Hua Zhang, You-Ming Zhang, Wen-Juan Qu, Bingbing Shi, Hong Yao, Tai-Bao Wei
Summary: In this paper, a series of tripodal nitrogen mustard derivatives (TMs) were developed, and the host-guest binding model was successfully tuned by rationally designing the intramolecular alkyl chain lengths of the host. This transformation from pi-pi to multiple hydrogen bonds enhanced the host-guest binding force and recognition efficiency.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Zibin Zhang, Yu Yao, Lang He, Tao Hong, Shijun Li, Feihe Huang, Peter J. Stang
Summary: Coordination-driven self-assembly was utilized to construct two metallacycles using a dicarboxylate-functionalized dibenzo-18-crown-6 in combination with either a 0 degrees anthracene-based clip-type acceptor or a 60 degrees phenanthrene-based acceptor. The angularities of these components enabled the formation of a [2 + 2] rectangle and a [3 + 3] triangle, respectively. The synthesis, characterization, and host-guest chemistry of the two metallacycles were described and supported by 31P{1H}, 1H NMR spectra, and electrospray mass spectrometry. (c) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Zhiguo Zhang, Xiyang Cao, Xiaoqing Song, Gang Wang, Bingbing Shi, Xiang Li, Nana Ma, Lantao Liu, Guisheng Zhang
Summary: Atom- and step-economy in IBX-assisted diversity-oriented synthesis is achieved with a versatile AQ auxiliary alpha-amino acid analogs, offering rapid access to polycyclic spiro-quinolines featuring a quaternary stereocenter in 20%-91% yields under mild conditions via 7,8-dearomatization of quinolines. The highlight of this intramolecular oxidation spiroannulation tandem reaction is the absence of a preinstalled activation group. These traditionally difficult-to-access N-heterospirocycles may provide a potentially interesting scaffold for synthetic and medicinal chemistry.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Xiao-Mei Sun, Juan Liu, Zhao-Hui Li, Yong-Peng Fu, Ting-Ting Huang, Zhong-Di Tang, Bingbing Shi, Hong Yao, Tai-Bao Wei, Qi Lin
Summary: In the past twenty years, aggregation-induced emission (AIE) has gained widespread interest due to its promising applications. The development of novel and easily synthesized AIE luminogens (AIEgens) is a fascinating research topic. This study aims to investigate the structure-property relationship of AIEgens by using a series of azine derivatives (ADs) as models.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Yu Yao, Jiyong Liu, Peiling Zhang, Kechang Sun, Leqiong Jin, Shijun Li, Feihe Huang, Zhigang Ni, Zibin Zhang
Summary: Self-assembly is a fundamental tool for constructing materials. Copillar[5]arenes, driven by CH center dot center dot center dot 7r interactions, are optimal models for building heteroditopic monomers. The self-assembly manner of copillar[5]arenes in the solid state depends on the competition between the pillar[5]arene cavity and the threading guest moiety or solvent molecules.
CRYSTAL GROWTH & DESIGN
(2023)
Review
Chemistry, Multidisciplinary
Peiren Liu, Fang Fang, Haochen Wang, Niveen M. Khashab
Summary: Stimuli-responsive or smart materials have had a significant impact on material science and engineering, thanks to the exponential development of synthetic host molecules (SHMs) and their corresponding host-guest chemistry. This Minireview presents recent advancements in synthetic host-based smart materials, including fabrication strategies and state-of-the-art applications such as adsorption, separation, luminescence, self-healing, and actuation. The role of host-guest chemistry is highlighted throughout to showcase the potential of emerging materials for future economies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Xiaodan Xu, Rui Wang, Dongdong Li, Jiajia Xiang, Wei Zhang, Xueying Shi, Hongxia Xu, Shasha Yao, Jiwei Liu, Shiqun Shao, Zhuxian Zhou, Feihe Huang, Youqing Shen, Jianbin Tang
Summary: In this study, a pH-responsive polymer nanocarrier modified with aminoguanidine was developed for efficient delivery of bortezomib. The nanoparticles exhibited pH-responsive release in the acidic tumor microenvironment and induced immune activation and antigen uptake by dendritic cells. Consequently, they stimulated cytotoxic T lymphocyte infiltration and triggered robust antitumor immune responses, showing potent antitumor efficacy when combined with an immune checkpoint-blocking antibody.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Huaqiang Ju, Haoke Zhang, Li Xin Hou, Min Zuo, Miao Du, Feihe Huang, Qiang Zheng, Zi Liang Wu
Summary: We propose a facile strategy to achieve room-temperature phosphorescence in conventional hydrogels by polymerization-induced crystallization of dopant molecules, leading to clusterization-induced phosphorescence. Crown ethers dissolved in a concentrated acrylamide aqueous solution crystallize during polymerization to form large spherulites in the hydrogel, resulting in carbonyl clusters and phosphorescence emission. This strategy is universally applicable to hydrogels with different polymeric matrices and dopant molecules. The development of hydrogels with mechanical and phosphorescent properties holds great potential in the biomedical and engineering fields.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Huangtianzhi Zhu, Junkai Liu, Yitao Wu, Lei Wang, Haoke Zhang, Qi Li, Hu Wang, Hao Xing, Jonathan L. Sessler, Feihe Huang
Summary: In this study, a room-temperature phosphorescence (RTP) system responsive to alkyl halides was described. The system consisted of a meta-formylphenyl-bearing pillar[5]arene derivative that supported effective through-space charge transfer. Treatment with bromoethane enhanced the emission. An isomeric para-formylphenyl-bearing pillar[5]arene system proved ineffective in producing an RTP effect.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Biochemistry & Molecular Biology
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao, Yuan Ding, Weilin Wang
Summary: With the increasing demand for personalized medical care, supramolecular theranostic systems based on cyclodextrins (CDs) have become popular due to their reversible switchable structures, sensitive response to biological stimuli, and ability to integrate multiple capabilities in a programmable manner. This review focuses on the design of various functional modules and interactions in CD-based supramolecular systems for cancer diagnostics and therapeutics. By providing state-of-the-art examples, the review aims to enhance the understanding of the important role of cyclodextrin-based nanoplatforms in advancing supramolecular cancer theranostics.
Review
Polymer Science
Ruoqian Zhang, Rongrong Li, Feihe Huang, Mingming Zhang
Summary: This review summarizes the progress of metallacycle/metallacage-cored supramolecular networks, focusing on the structures connected by covalent or non-covalent interactions. The detailed descriptions of the structures, properties, functions, and applications of such networks are provided to showcase the exciting achievements in this emerging field. The review also highlights the remaining challenges and perspectives to attract more scientists to contribute to this promising area.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Zuping Xiong, Jianyu Zhang, Lei Wang, Yuan Xie, Yipu Wang, Zujin Zhao, Haoke Zhang, Jing Zhi Sun, Feihe Huang, Ben Zhong Tang
Summary: Nonconjugated clusteroluminogens (CLgens), such as proteins and polystyrene, have become increasingly important in photophysics due to their advantages over traditional conjugated dyes in biological applications. However, their weak visible emissions in the aggregate state have hindered their development. This study proposes a strategy to construct a higher-level intramolecular through-space interaction (TSI) in multi-aryl-substituted alkanes, resulting in efficient clusteroluminescence (CL) with high luminescence quantum yield and long emission wavelength.
Article
Chemistry, Multidisciplinary
Bohan Zhao, Jianwei Wang, Li Shao, Yitao Wu, Ming Li, Bin Hua, Feihe Huang
Summary: An efficient adsorptive separation method using nonporous adaptive crystals of perbromoethylated pillar[5]arene (BrP5) for monobromotoluene isomers is reported. The purity of separated m-bromotoluene from an equal volume mixture of m-bromotoluene and o-bromotoluene reaches 96.6% in one cycle, and the adsorbent BrP5 can be reused without losing separation performance.
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Dan Wu, Jiaqi Lei, Zhankui Zhang, Feihe Huang, Marija Buljan, Guocan Yu
Summary: The synthesis of vital biomacromolecules through the polymerization of small biomolecules to support and multiply life is an emerging field that showcases the diversity and efficiency of chemistry as well as the flexibility and ingenuity of physiological environment. Efforts have been made to design and develop in situ intra/extracellular polymerization reactions, which have found applications in various important research areas, including cell surface engineering, biocompatible polymerization, cell behavior regulation, living cell imaging, targeted bacteriostasis, and precise tumor therapy.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Haozhong Liang, Yuting Yang, Li Shao, Weijie Zhu, Xiaofeng Liu, Bin Hua, Feihe Huang
Summary: In this study, pillar[5]arene was used as a host molecule to encapsulate NLO molecules (OM, DAST, and MNS) in order to change their solid-state packing and manipulate their centrosymmetric arrangements. Experimental results showed that different packing arrangements resulted in different levels of second harmonic generation (SHG). This research provides a new approach to construct solid-state organic NLO materials with potential applications in high-power lasers, optical switches, and imaging.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
