期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 15, 页码 3721-3724出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201800314
关键词
carbenes; dearomatization; gold; spirocyclohexadienones; water
资金
- JST, ACT-C, Japan
- Waseda University Grant for Special Research Projects
- Early Bird grant for young researcher at Waseda Research Institute for Science and Engineering
An intramolecular catalytic dearomatization of phenols via gold carbene species proceeded to provide 2-azaspiro[4.5]decan-3-ones. The use of NHC ligand and water as a co-solvent was critical for achieving high reactivity. This reaction did not require hazardous diazo compounds as carbene sources and proceeded even under air. The obtained spirocyclic product could be readily transformed into a gabapentin derivative by hydrogenation and deprotection.
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