期刊
CHEMISTRY OF MATERIALS
卷 30, 期 2, 页码 517-525出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemmater.7b04751
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资金
- National Key R&D Program of China [2017YFA0205601]
- National Natural Science Foundation of China [51473043, 51773067, 51603150]
- Natural Science Foundation for Distinguished Young Scholars of Guangdong Province [2017B030306002]
- Fundamental Research Funds for the Central Universities
Drug delivery systems with remotely controlled drug release capability are rather attractive options for cancer therapy. Herein, a reactive oxygen species (ROS)-sensitive polymeric nanocarrier TK-PPE@NPCe6/DOX was explored to realize remotely controlled drug release by light-activated size shrinkage. The TK-PPE@NPCe6/DOX encapsulating chlorin e6 (Ce6) and doxorubicin (DOX) was self-assembled from an innovative ROS-sensitive polyiner TK-PPE with the assistance of an amphiphilic copolymer poly(ethylene glycol)-b-poly(epsilon-caprolactone) (PEG-b-PCL). Under the 660 nm red light irradiation, ROS generated by the encapsulated Ce6 were capable,of cleaving the TK linker in situ, which resulted in the rapid degradation of the TK-PPE@NPCe6/DOX core. Consequently, the size of TK-PPE@NPCe6/DOX shrank from 154 +/- 4 nm to 72 +/- 3 nm, and such size shrinkage affected further triggered rapid DOX release. As evidenced by both in vitro and in vivo experiments, such ROS-sensitive polymeric nanocarriers with light-induced size shrinkage capability offer remarkable therapeutic effects in cancer treatment. This concept provides new avenues for the development of light-activated drug delivery systems for remotely controlled drug release in vivo.
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