Article
Biotechnology & Applied Microbiology
Nisha Mahey, Rushikesh Tambat, Dipesh Kumar Verma, Nishtha Chandal, Krishan Gopal Thakur, Hemraj Nandanwar
Summary: In this study, the researchers identified five azoles as potential efflux pump inhibitors (EPIs) for Staphylococcus aureus, demonstrating synergistic effects with tetracycline against the bacterium and reducing biofilm formation significantly at clinically relevant concentrations. This suggests that repurposing approved drugs like azoles could be a promising strategy for combating antimicrobial resistance and reducing biofilm formation in clinical settings.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Chemistry, Applied
Debora Feitosa Muniz, Cristina Rodrigues dos Santos Barbosa, Irwin Rose Alencar de Menezes, Erlanio Oliveira de Sousa, Raimundo Luiz Silva Pereira, Joao Tavares Calixto Junior, Pedro Silvino Pereira, Yedda M. L. S. de Matos, Roger H. S. da Costa, Cicera Datiane de Morais Oliveira-Tintino, Henrique Douglas Melo Coutinho, Jose Maria Barbosa Filho, Gabriela Ribeiro de Sousa, Jaime Ribeiro Filho, Jose Pinto Siqueira-Junior, Saulo Relison Tintino
Summary: This study evaluated the antibacterial activity of eugenol and its derivatives against Staphylococcus aureus NorA efflux pump, showing synergistic effects with some compounds. The findings suggest the potential use of eugenol derivatives in antibacterial drug development, particularly in strains carrying the NorA pump.
Article
Microbiology
Nisha Mahey, Rushikesh Tambat, Nishtha Chandal, Dipesh Kumar Verma, Krishan Gopal Thakur, Hemraj Nandanwar
Summary: This study identified six clinically approved drugs that can inhibit the NorA efflux pump, showing synergism with fluoroquinolones and reducing antibiotic resistance in Staphylococcus aureus. These drugs also displayed anti-biofilm properties and efficacy in treating severe S. aureus infections in animal models.
MICROBIOLOGY SPECTRUM
(2021)
Article
Biochemistry & Molecular Biology
Gautam Kumar, Asha Kiran Tudu
Summary: Staphylococcus aureus (S. aureus) is a pathogen responsible for various infections with life-threatening complications. The misuse of antibiotics has led to the emergence of multidrug-resistant pathogens. Bacteria have developed mechanisms to avoid the effects of antibiotics. Inhibitors of multidrug efflux pumps are considered alternative therapeutic options. Natural products and their derived compounds can serve as NorA efflux pump inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Microbiology
Nishtha Chandal, Rushikesh Tambat, Ritu Kalia, Gautam Kumar, Nisha Mahey, Sanjay Jachak, Hemraj Nandanwar
Summary: In this study, a chemically synthesized indole derivative, SMJ-5, was found to be a potent NorA efflux pump inhibitor in Staphylococcus aureus. It increased the accumulation of ethidium bromide and norfloxacin, eradicated biofilm, and prolong the post-antibiotic effect when combined with ciprofloxacin. SMJ-5 also inhibited the staphyloxanthin virulence and showed enhanced bactericidal activity against S. aureus. Additionally, SMJ-5 indirectly inhibited the NorA efflux pump at the transcriptional level.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Nishtha Chandal, Rushikesh Tambat, Ritu Kalia, Gautam Kumar, Nisha Mahey, Sanjay Jachak, Hemraj Nandanwar
Summary: In this study, chemically synthesized indole derivatives were screened and a potent NorA efflux pump inhibitor, SMJ-5, was identified. The combination of SMJ-5 and ciprofloxacin showed enhanced bactericidal activity against S. aureus, and could eradicate S. aureus biofilm and prolong the post-antibiotic effect. SMJ-5 also inhibited staphyloxanthin virulence and NorA efflux pump at the transcriptional level indirectly.
MICROBIOLOGY SPECTRUM
(2023)
Review
Biochemistry & Molecular Biology
Bhawandeep Kaur, Jeena Gupta, Sarika Sharma, Divakar Sharma, Sandeep Sharma
Summary: Staphylococcus aureus is a common pathogen causing various infections, with Methicillin-Resistant Staphylococcus aureus (MRSA) being particularly concerning. The primary antimicrobial resistance mechanisms in S. aureus involve efflux pumps and biofilm formation, with quorum sensing and drug efflux playing crucial roles. Efflux pump inhibitors (EPIs) have been identified as a promising approach to combat bacterial resistance, by inhibiting drug efflux mechanisms and transport of quorum sensing signalling molecules.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Fatima Naaz, Arif Khan, Anchala Kumari, Intzar Ali, Faiz Ahmad, Bilal Ahmad Lone, Nazia Ahmad, Inshad Ali Khan, Vikrant Singh Rajput, Abhinav Grover, Syed Shafi
Summary: The NorA efflux pump plays a key role in antibiotic resistance in Staphylococcus aureus. A capsaicin-based compound, 17i, showed significant inhibitory effects on NorA and could potentially serve as a template for drug discovery.
BIOORGANIC CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Janaina Esmeraldo Rocha, Thiago Sampaio de Freitas, Jayze da Cunha Xavier, Raimundo Luiz Silva Pereira, Francisco Nascimento Pereira Junior, Carlos Emidio Sampaio Nogueira, Marcia Machado Marinho, Paulo Nogueira Bandeira, Mateus Rodrigues de Oliveira, Emmanuel Silva Marinho, Alexandre Magno Rodrigues Teixeira, Helcio Silva dos Santos, Henrique Douglas Melo Coutinho
Summary: A large number of infections worldwide are caused by multi-resistant bacteria, resulting in approximately 700,000 deaths per year. Chalcones, a class of compounds known for their broad biological activities, including antimicrobial and anticancer properties, are being studied for their potential to combat microbial drug resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Medicinal
Tommaso Felicetti, Nicholas Cedraro, Andrea Astolfi, Giada Cernicchi, Gianmarco Mangiaterra, Salvatore Vaiasicca, Serena Massari, Giuseppe Manfroni, Maria Letizia Barreca, Oriana Tabarrini, Francesca Biavasco, Violetta Cecchetti, Carla Vignaroli, Stefano Sabatini
Summary: Antimicrobial resistance (AMR) is a serious global health issue. Efflux pumps play a significant role in the development of resistance and biofilm formation. The search for non-antibiotic molecules that can block efflux pumps is a promising strategy. This study reports a new series of potent derivatives that block efflux pumps and demonstrate synergy with ciprofloxacin against resistant strains of Staphylococcus aureus.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Microbiology
Honghao Huang, Peng Wan, Xinyue Luo, Yixing Lu, Xiaoshen Li, Wenguang Xiong, Zhenling Zeng
Summary: Previous analysis has shown that overexpression of MepA is an exact mechanism involved in tigecycline resistance apart from the rpsJ mutation and is usually dependent on the mutant mepR. However, no research has evaluated the effects of diverse mutations discovered in TRSA in MepA. This study explores mutations in the mepA genes and identifies tigecycline resistance-associated mutations T29I, E287G, and T29I+E287G in MepA, demonstrating their role in promoting tigecycline efflux and providing genetic references for identifying TRSA.
MICROBIOLOGY SPECTRUM
(2023)
Article
Chemistry, Multidisciplinary
Maria Rayane Correia de Oliveira, Maria Gabriely de Lima Silva, Cicera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Janaina Esmeraldo Rocha, Francisco Ernani Alves Magalhaes, Roger Henrique Sousa da Costa, Renata Torres Pessoa, Isabel Sousa Alcantara, Anita Oliveira Brito Pereira Bezerra Martins, Henrique Douglas Melo Coutinho, Antonio Raposo, Conrado Carrascosa, Jose Raduan Jaber, Rogerio Aquino Saraiva, Irwin Rose Alencar de Menezes
Summary: The present study evaluated the antibacterial effect and inhibitory capacity of a, b, and d-damascone compounds against multidrug-resistant Staphylococcus aureus. These compounds showed clinically relevant effects against S. aureus standard strain and modulating effects with antibiotics against multidrug-resistant strains. They also demonstrated a modulating effect with antibiotics on efflux pumps, with d-damascone showing an inhibitory effect. In terms of ADME properties, a, b, and d-damascone exhibited favorable physicochemical properties, pharmacokinetic characteristics, and good interactions with the critical residues of the MepA receptor.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Infectious Diseases
Elisa Rampacci, Tommaso Felicetti, Giada Cernicchi, Valentina Stefanetti, Stefano Sabatini, Fabrizio Passamonti
Summary: One approach to treating antibiotic-resistant bacteria is to co-administer efflux pump inhibitors (EPIs) with antibiotics to break resistances connected with antibacterial efflux. In this study, ten compounds were evaluated for their ability to inhibit efflux and synergize with different antibiotics in Staphylococcus pseudintermedius. Hit compounds 1, 6, and 8 were considered the best EPIs for S. pseudintermedius. These findings provide valuable data for further optimization and development of EPIs for treating staphylococcal infections.
Article
Medicine, Research & Experimental
Katerina Holasova, Bara Krizkovska, Lan Hoang, Simona Dobiasova, Jan Lipov, Tomas Macek, Vladimir Kren, Katerina Valentova, Tomas Ruml, Jitka Viktorova
Summary: Antibiotic resistance is a serious health problem, and the discovery of new antibiotics alone is no longer sufficient in combating multidrug-resistant infections. Adjuvant therapy and reducing bacterial virulence are gaining importance. Silymarin, a complex of flavonoids and flavonolignans, has a wide range of biological activities and can modulate drug resistance in cancer. This study tested eleven optically pure silymarin flavonolignans and found that some of them can reverse the multidrug resistance phenotype of Staphylococcus aureus and reduce its virulence.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Banani Deka, Mrinaly Suri, Sangita Sarma, Anamika Bora, Tejosmita Sen, Anjum Dihingia, Pallab Pahari, Anil Kumar Singh, Moirangthem Veigyabati Devi
Summary: The study synthesized 17 dihydroquinazoline analogues and found that they significantly reduced drug resistance in S. aureus 1199B as NorA efflux pump inhibitors, with low toxicity in human cells, indicating potential as a therapeutic approach.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Paulo Fernando da Silva Santos Junior, Joao Xavier de Araujo Junior, Edeildo Ferreira da Silva Junior
Summary: Infections caused by the Hepatitis C virus (HCV) have a global impact, affecting 70 million people and leading to serious liver problems. Despite therapeutic advancements, a significant percentage of infected individuals are unable to eliminate the virus, highlighting the need for effective antiviral strategies. Targeting the entry of HCV into host cells has emerged as a promising approach for developing antiviral molecules.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Joao Paulo Noe, Jamylle Nunes De Souza-Ferro, Erica Erlanny Da Silva-Rodrigues, Edeildo Ferreira Da Silva-Junior, Magna Suzana Alexandre-Moreira, Joao Xavier De Araujo-Junior, Emiliano Barreto
Summary: In this study, a compound called LQM10 was found to have antinociceptive and anti-inflammatory effects in mice. LQM10 reduced nociceptive behavior in certain pain models and inhibited inflammatory responses in carrageenan-induced pleurisy. These results suggest that LQM10 has potential as a treatment for pain and inflammation by acting on peripheral mechanisms and reducing leucocyte migration and proinflammatory mediators.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Microbiology
Natalia Ferreira de Sousa, Helivaldo Diogenes da Silva Souza, Renata Priscila Barros de Menezes, Francinara da Silva Alves, Chonny Alexander Herrera Acevedo, Thais Amanda de Lima Nunes, Zoe L. Sessions, Luciana Scotti, Eugene N. Muratov, Francisco Jaime Bezerra Mendonca-Junior, Klinger Antonio da Franca Rodrigues, Petronio Filgueiras de Athayde Filho, Marcus Tullius Scotti
Summary: The World Health Organization classifies Leishmania as one of the 17 neglected diseases. We analyzed organoselenides for potential anti-leishmanial effects due to their reduced toxicity and displayed biological activity. In silico models predicted the activity of 77 compounds, and subsequent experimental validation confirmed the effectiveness of the methodology, with several compounds showing strong inhibition profiles.
Article
Chemistry, Medicinal
Sonaly Lima Albino, Willian Charles da Silva Moura, Malu Maria Lucas dos Reis, Gleyton Leonel Silva Sousa, Pablo Rayff da Silva, Mayara Gabriele Carvalho de Oliveira, Tatiana Karla dos Santos Borges, Lucas Fraga Friaca Albuquerque, Sinara Monica Vitalino de Almeida, Maria do Carmo Alves de Lima, Selma Aparecida Souza Kuckelhaus, Igor Jose dos Santos Nascimento, Francisco Jaime Bezerra Mendonca Jr, Teresinha Goncalves da Silva, Ricardo Olimpio de Moura
Summary: The present study synthesized a new acridine derivative and characterized its chemical properties. Its potential as an antileishmanial agent was investigated through in vitro assays. The compound showed good antileishmanial activity and non-cytotoxicity to macrophages. It also exhibited a slight immunomodulatory activity and interacted with DNA, suggesting a potential molecular target.
Review
Chemistry, Medicinal
Weslany Souza Rocha, Peng Zhan, Edeildo Ferreira da Silva
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has led to millions of deaths and poses a serious threat to public health. The emergence of novel SARS-CoV-2 variants, such as the Omicron variant, with multiple mutations and increased transmissibility, has further worsened the situation. The Omicron variant is able to evade the host immune system, making it resistant to neutralizing antibodies and some vaccines. It is crucial to study and develop effective antiviral agents to combat this threatening variant.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Isadora Silva Luna, Thalisson Amorim de Souza, Marcelo Sobral da Silva, Klinger Antonio da Franca Rodrigues, Luciana Scotti, Marcus Tullius Scotti, Francisco Jaime Bezerra Mendonca-Junior
Summary: In this study, a series of 2-amino-thiophene (2-AT) derivatives were virtually screened and evaluated using cheminformatics tools. Eleven potential anti-leishmanial 2-AT derivatives were identified, which exhibited good activity against the parasite and low cytotoxicity. Ligand-based virtual screening proved to be effective in selecting candidates for the development of new anti-leishmanial agents, and 2-AT derivatives showed promise as hit compounds.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jessica Alves Nunes, Rodrigo Santos Aquino de Araujo, Fabricia Nunes da Silva, Joanna Cytarska, Krzysztof Z. Laczkowski, Silvia Helena Cardoso, Francisco Jaime Bezerra Mendonca-Junior, Edeildo Ferreira da Silva-Junior
Summary: Cancer is a serious global health problem, with melanoma as the most aggressive and fatal type of skin cancer. Coumarin-based compounds, such as FN-19, have shown potential as anti-melanoma agents and tyrosinase inhibitors. The study demonstrated that FN-19 exhibited potent anti-tyrosinase activity, acting as a mixed inhibitor, and its binding with tyrosinase was stabilized by van der Waals interactions. The data obtained from this study will be valuable for the development of novel coumarin-based analogs targeting the tyrosinase enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Fernando Ferreira Leite, Natalia Ferreira de Sousa, Bruno Hanrry Melo de Oliveira, Gabrielly Diniz Duarte, Maria Denise Leite Ferreira, Marcus Tullius Scotti, Jose Maria Barbosa Filho, Luis Cezar Rodrigues, Ricardo Olimpio de Moura, Francisco Jaime Bezerra Mendonca-Junior, Luciana Scotti
Summary: This study investigated the role of natural and synthetic chalcones and their anticancer activity in vitro reported from 2019 to 2023. The analysis found that the presence of polar radicals such as hydroxyl and methoxyl contributed to the anticancer activity of chalcones derivatives. The results hope to aid in the development of effective drugs to inhibit colon adenocarcinoma.
Review
Chemistry, Medicinal
Jessica Alves Nunes, Adrielle Firmino da Silva Nunes, Dimas Jose da Paz Lima, Edeildo Ferreira da Silva
Summary: This review summarizes the studies on the application of natural naphthoquinones in targeting melanoma, providing information on the mechanisms of action investigated for these compounds. It may contribute to the discovery of promising compounds for the treatment of melanoma.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Editorial Material
Chemistry, Medicinal
Chuanfeng Liu, Lide Hu, Huinan Jia, Jiwei Zhang, Guanyu Dong, Edeildo Ferreira da Silva-Junior, Xinyong Liu, Peng Zhan
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jessica Alves Nunes, Fabricia Nunes da Silva, Elany Barbosa da Silva, Clara Andrezza Crisostomo Bezerra Costa, Johnnatan Duarte de Freitas, Francisco Jaime Bezerra Mendonca-Junior, Miriam Aparecida Giardini, Jair Lage de Siqueira-Neto, James H. McKerrow, Thaiz Rodrigues Teixeira, Louis William Odeesho, Conor R. Caffrey, Silvia Helena Cardoso, Edeildo Ferreira da Silva-Junior
Summary: A virtual fragment-based drug design approach was used to develop coumarin-based analogs that can inhibit two cysteine proteases of Trypanosoma cruzi and T. brucei. One compound, FN-27, showed inhibitory activity against both CRZ and TbrCATL, as well as trypanocidal activity against T. cruzi-infected cells. Another compound, FN-10, exhibited activity against T. brucei trypomastigotes but did not inhibit CRZ or TbrCATL. Molecular dynamics simulations confirmed the binding modes of FN-27 with both proteases. These findings are valuable for the development of novel natural-product-based inhibitors targeting these cysteine proteases.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Chuanfeng Liu, Ying Zhang, Ping Li, Huinan Jia, Jiwei Zhang, Edeildo Ferreira da Silva-Junior, Sunanda Samanta, Parimal Kar, Bing Huang, Xinyong Liu, Peng Zhan
Summary: Compound IIB-2, identified through structural optimization, demonstrated comparable inhibitory effects on oseltamivir-resistant strains to its precursor compound A9, while exhibiting reduced toxicity. Further investigations revealed that compound IIB-2 impedes virus proliferation by blocking the export of influenza virus nucleoprotein.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)