Article
Chemistry, Physical
Yungeun Kwon, Wei Zhang, Qiu Wang
Summary: A copper-catalyzed aminoheteroarylation of unactivated alkenes was developed for the synthesis of valuable heteroarylethylamine motif. This reaction is applicable to alkenes containing alcohol, amide, and ether groups, allowing for the introduction of diverse aliphatic amines. The migration-involved reaction serves as a powerful ring-expansion approach in medicinal chemistry.
Article
Nanoscience & Nanotechnology
Y. Zhao, A. V. Kuklin, H. Huang, Q. Zhang, S. Wei, H. Zhang, C. Yu, Y. Li, H. Agren, L. Gao
Summary: Bi nanoplatelets (NPLs) with narrow size distribution and high yield were fabricated by a novel two-step sonication-assisted solvothermal method. The Bi NPLs exhibited pronounced photo-response from ultraviolet to visible regions when used as photo-electrochemical (PEC)-type photodetectors (PDs). The photo-response performance of Bi NPLs-based PDs was adjusted by external conditions and interpreted by density functional theory calculations. The optimal photocurrent density (P-ph) and photoresponsivity (R-ph) of Bi NPLs-based PDs reached 12.27 µA/cm² and 3016 µA/W in alkaline electrolytes, respectively. Moreover, the Bi NPLs-based PDs demonstrated superb long-term cycling stability (around 97.86% remained after 1000 cycles). Bi NPLs show great promise as a building block for high-performance PEC-type PDs and other optoelectronic devices.
MATERIALS TODAY NANO
(2023)
Review
Chemistry, Multidisciplinary
Yuval Elani
Summary: The construction of artificial cells is a major challenge today, with potential applications in clinical and industrial settings. Artificial cells currently cannot match the complexity of biological cells, leading researchers to explore hybrid living/synthetic systems that combine the advantages of both.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Juanjuan Wang, Wei-Hai Fang, Ling-Bo Qu, Lin Shen, Feliu Maseras, Xuebo Chen
Summary: This study expands an innovative single electron transfer (SET) model by integrating nonadiabatic crossing with the rate-determining step of 1,5-hydrogen atom transfer (HAT) reactions, providing a control mechanism for radical decay dynamics in the amide-directed distal sp(3) C-H bond alkylation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Chemistry, Multidisciplinary
Zheao Zhang, Kelong Fan
Summary: Transition metal catalysts (TMCs) based bioorthogonal reactions have potential for biomedical applications, but their toxicity, stability and targeting properties limit their widespread use in vivo. Bioorthogonal nanozymes, which combine the catalytic activity of TMCs, physical and chemical properties of nanomaterials, and enzymatic properties of classical nanozymes, provide opportunities to address these challenges and serve as multifunctional catalytic platforms for disease treatment.
Review
Multidisciplinary Sciences
Mirja Md Mahamudul Hassan, Saikat Guria, Sayan Dey, Jaitri Das, Buddhadeb Chattopadhyay
Summary: Transition metal-catalyzed C-H bond activation and borylation is a powerful synthetic method for transforming organoboron compounds to various functional groups. Remote C-H borylation is more challenging than ortho-borylation due to the inaccessibility of the C-H bonds. Recent discoveries in catalyst/ligand design, such as steric effects and noncovalent interactions, have enabled remote C-H borylation and its application in natural product synthesis. Ir-catalyzed C-H borylation is currently predominant, but cobalt catalysts are also being explored for sustainable and cost-effective development.
Article
Environmental Sciences
Valeria Lencioni, Cristiana Rizzi, Mauro Gobbi, Andrea Mustoni, Sara Villa
Summary: Pesticides, synthetic fragrances and polycyclic aromatic hydrocarbons have contaminated glacier-fed streams and a spring in the Italian Alps, accumulating in aquatic larvae and carabids. The concentration of xenobiotics was higher in larvae than in water, indicating trophic transfer to riparian predators.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Engineering, Biomedical
He Ding, Jinhu Chang, Fei He, Shili Gai, Piaoping Yang
Summary: Advances in nanotechnology have led to the rapid development of therapeutic nanomaterials for gas therapy, particularly with H2S-responsive properties. The interdisciplinary study of H2S is a scientific hotspot exploring its chemical properties, biological mechanisms, and therapeutic effects, showcasing potential for treating diseases in biological systems.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Physical
Arjan Atwal, Tina P. Dale, Martyn Snow, Nicholas R. Forsyth, Pooya Davoodi
Summary: The impairment of articular cartilage poses challenges, but recent advancements in regenerative medicine, particularly the use of injectable hydrogels, offer promising prospects for cartilage regeneration. Hydrogels can mimic the characteristics of native cartilage and provide minimally invasive delivery of bioactive agents to the damaged site, accelerating cartilage healing and modulating inflammation.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Nanoscience & Nanotechnology
Yating Xu, Anqi Chen, Jiehong Wu, Yan Wan, Mingfeng You, Xinmei Gu, Hongxiu Guo, Sengwei Tan, Quanwei He, Bo Hu
Summary: This review discusses the recent advances in nanomedicines for the treatment of hemorrhagic stroke, including hemostasis, drug delivery, neuroprotection, and nerve regeneration. Nanomedicines offer new possibilities for effective therapies for hemorrhagic stroke.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Immunology
Amrita Das, Nahid Ali
Summary: Nanovaccines, as efficient vaccine delivery systems, show great potential in improving tissue targeting, antigen presentation, and targeted delivery, providing promising strategies to combat infectious diseases and cancer.
EXPERT REVIEW OF VACCINES
(2021)
Article
Chemistry, Multidisciplinary
Jamie A. Leitch, Duncan L. Browne
Summary: Recent research has shown that mechanochemical activation of piezoelectric materials can open new avenues in redox chemistry, mimicking established photoredox catalytic cycles. Proof-of-concept studies have demonstrated that mechanoredox chemistry holds great potential in sustainable and efficient radical-based synthesis.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Popat Kumbhar, Kapil Kole, Tejashree Yadav, Ashwini Bhavar, Pramod Waghmare, Rajdeep Bhokare, Arehalli Manjappa, Niraj Kumar Jha, Dinesh Kumar Chellappan, Sunita Shinde, Sachin Kumar Singh, Kamal Dua, Ahmad Salawi, John Disouza, Vandana Patravale
Summary: Skin cancer is a common form of cancer, and its treatment with chemotherapy has limitations. Drug repurposing, using previously approved drugs for the treatment of other diseases like cancer, offers a promising approach with advantages in time and cost.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Chemistry, Physical
Shuya Wang, Qiaohui Chen, Tianjiao Zhao, Kelong Ai, Changping Hu
Summary: Pulmonary hypertension (PH) is a deadly disease with a high incidence and limited treatment options. Nanomedicines have shown great potential in the treatment of PH by improving drug delivery, enhancing drug efficacy, and reducing side effects. However, there are significant professional barriers hindering the exploration of this promising field. This comprehensive review provides an overview of the pathological features of PH, current treatment options, and the progress of nanomedicines in PH treatment.
Review
Biochemistry & Molecular Biology
Francisco Sadras, Gregory R. Monteith, Sarah J. Roberts-Thomson
Summary: Tumors interact with their microenvironment, particularly with cancer-associated fibroblasts (CAFs), which play a significant role in supporting cancer development through various processes like cell-cell contact, paracrine signaling, and extracellular matrix remodeling. Calcium signaling, a key player in intra- and intercellular pathways, is less explored in connection with CAFs, but it contributes to cancer progression, especially in processes like migration, proliferation, chemoresistance, and genetic instability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Sheng Tang, Hong-Hao Zhang, Shouyun Yu
Summary: A dual photoredox/palladium catalyzed regio- and enantioselective reductive cross-coupling of allylic acetates with tertiary/secondary alkyl bromides has been achieved using Hantzsch ester as a homogeneous organic reductant. This protocol facilitates the stereoselective construction of C(sp(3))-C(sp(3)) bonds under mild conditions.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Qing-Yun Fang, Jie Han, Mingzhe Qin, Weipeng Li, Chengjian Zhu, Jin Xie
Summary: Reported here is a three-component 1,2-difunctionalization reaction of alkenes, unactivated alkyl bromides, and nucleophiles (e.g., amines and indoles) using a trinuclear gold catalyst [Au-3(tppm)(2)](OTf)(3). This reaction enables facile 1,2-aminoalkylation and 1,2-alkylarylation and exhibits a broad reaction scope and excellent functional group compatibility (>100 examples with up to 96% yield). It also provides a robust formal [2+2+1] cyclization strategy for the concise construction of pyrrolidine skeletons under mild reaction conditions. Mechanistic studies support an inner-sphere single electron transfer pathway for the successful cleavage of inert C-Br bonds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Wenliang Wang, Meiling Ding, Chuan-Gang Zhao, Shuai Chen, Chengjian Zhu, Jie Han, Weipeng Li, Jin Xie
Summary: In this study, a gold(I)-catalyzed iodo-alkynylation of benzyne was reported, which involves the merging of migratory insertion and oxidative addition processes in the gold catalytic cycle. Various alkynyl iodides, both aliphatic and aromatic, are good coupling partners in this transformation, leading to highly functionalized 1,2-disubstituted aromatics in moderate to good yields. The reaction exhibits good compatibility with functional groups and can be applied to complex molecules, demonstrating its synthetic robustness. Mechanistic studies suggest the feasibility of oxidative addition and DFT calculations support the possible migratory insertion of benzyne into Au-III-carbon bonds, representing an important step towards understanding elementary reactions in gold chemistry research.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yubo Pang, Shuai Chen, Jie Han, Chengjian Zhu, Chuan-Gang Zhao, Jin Xie
Summary: Here we describe a manganese-catalyzed hydroalkenylation reaction that selectively introduces branched groups to terminal alkynes under mild conditions using a removable silanol directing group. Coupling with an alkenyl boronic acid partner yields (E,E)-1,3-dienes with high regio-, chemo- and stereoselectivity. The reaction proceeds at room temperature in air and is compatible with various functional groups. The resulting 1,3-dienesilanol products can be used as versatile building blocks for downstream synthesis of branched or linear 1,3-dienes and 1,3,5-trienes by removing the silanol group. Additionally, a Diels-Alder cycloaddition delivers silicon-containing pentasubstituted cyclohexenes. Mechanistic studies and DFT calculations support a bimetallic synergistic activation model for the enhanced catalytic efficiency and regioselectivity observed.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Shijie Wei, Hongcen Zheng, Jia-Jia Zhao, Shouyun Yu, Bingdang Wu, Guoyang Zhang, Shujuan Zhang
Summary: Self-sensitized degradation is a common fate of azo dyes in aquatic systems, but its kinetics is too slow for complete decolorization. Small diketones can enhance the degradation of dyes under UV irradiation, and the introduction of an electron-denoting group at the α-position of the simplest β-diketone (acetylacetone, AA) further enhances the degradation. However, it is unclear if such enhancement effects exist in solar-irradiated systems. To investigate this, the effects of three AA derivatives on Acid Orange 7 (AO7) were studied. 3,5-diacetylheptane-2,6-dione (AA-CH2-AA) showed over a 2-fold stronger enhancement effect compared to the derivatives with a methyl or ethyl group. Nonstoichiometric enhancement of AA-CH2-AA on AO7 photodegradation revealed a novel pathway for dye degradation.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Chuan-Gang Zhao, Chaoyu Du, Zhenyu Guo, Weipeng Li, Jie Han, Jin Xie
Summary: This study achieved the selective hydroalkenylation of unsaturated aldehydes and ketones using a cooperative catalysis strategy involving manganese and iminium catalysis. The method exhibits several advantages such as simple operation, good functional group compatibility, and good regioselectivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Duan-Yang Liu, Jie Han, Kai Liu, Yaohang Cheng, Hairen Tan, Xiaoliang Yang, Weipeng Li, Jin Xie
Summary: This study presents a gold-catalyzed para-C-H arylation reaction at room temperature, successfully applied to monofluoroarenes. The method shows high para-selectivity and a broad substrate scope, providing a concise and efficient strategy for constructing structurally diverse para-arylated monofluoroarenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Jie Han, Jin Xie
Summary: Photo-induced electron transfer is a crucial process in photochemical reactions, but traditional outer-sphere single electron transfer mechanisms have limitations due to the requirement of redox potential matching. In this review, we focus on the inner-sphere single electron transfer mechanism exhibited by polynuclear gold photocatalysts and emphasize its significant role in photocatalysis.
Article
Chemistry, Multidisciplinary
Meiling Ding, Sitian Zhou, Shunruo Yao, Chengjian Zhu, Weipeng Li, Jin Xie
Summary: In this paper, a mild and noble-metal-free method for the synthesis of secondary amines has been developed, which involves the decarboxylative amination of carboxylic acids with nitroarenes. This transformation provides structurally diverse secondary amines in good yields (up to 94%) with good functional group tolerance.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tao Zhong, Chengyihan Gu, Yuhang Li, Jun Huang, Jian Han, Chengjian Zhu, Jie Han, Jin Xie
Summary: In this paper, a novel bimetallic relay catalysis of Mn2(CO)10 and cobaloxime has been developed for the divergent dehydrogenative difluoroalkylation of alkenes using commercially available difluoroalkyl bromides. A wide range of structurally diverse difluoroalkylated allylic products and difluoromethylated cyclic products were efficiently synthesized, accompanied with the production of H2 as the by-product. This bimetallic relay strategy features broad substrate scope, mild reaction conditions, and excellent functional group compatibility.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Cheng-Long Ji, Xinyi Zhai, Qing-Yun Fang, Chengjian Zhu, Jie Han, Jin Xie
Summary: In recent years, the activation of unactivated alkyl chlorides through light-induced processes has become a promising field in radical chemistry, allowing for the easy construction of carbon-carbon and carbon-heteroatom bonds. Recent studies in medicinal chemistry show that their presence is associated with high success rates in clinical trials. This review summarizes the recent advances in the photoinduced activation of unactivated alkyl chlorides and discusses the underlying mechanistic aspects, aiming to inspire developments in organic chemistry, drug synthesis, materials science, and related disciplines.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Jie Ding, Ye Yang, Mingzhen Xue, Xukai Gong, Hu Cai, Wentao Xu
Summary: In this article, we showcase the utilization of continuous flow technology for the synthesis of hydrazine derivatives through deoxygenation of free alcohols using di-tert-butylazodicarboxylate. This straightforward method demonstrates excellent tolerance towards various functional groups and allows for large-scale synthesis and late-stage functionalization. Furthermore, it presents a pathway to access three families of pharmacological compounds.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jiajun Li, Xinyi Zhai, Cheng-Long Ji, Weipeng Li, Jin Xie
Summary: A dinuclear gold-catalyzed radical difunctionalization of alkyl bromides with 1,7-enynes has been developed via dehalogenation and 1,5-HAT processes. This protocol efficiently constructs cyclopenta[c]quinolines bearing two quaternary carbon centers with good yields (28 examples, up to 84% yield). The reaction exhibits excellent functional group compatibility and scalability, demonstrating its synthetic robustness.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Siyu Xia, Weipeng Li, Hongliang Chen, Chengjian Zhu, Jie Han, Jin Xie
Summary: In this study, the first visible-light-mediated, external oxidant-free Au(I)/Au(III) redox couple was reported. By using commercially available Mn-2(CO)(10) to generate Mn-Au(III)-Mn intermediates, a wide range of structurally diverse Au-Mn complexes can be readily constructed under mild reaction conditions, representing an important progress in gold chemistry research. The resulting complexes also exhibit unique catalytic activity and can be used for the synthesis of azoxybenzenes, azobenzenes, and hydrazobenzenes in moderate to good yields.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yi Jiao, Xiaoran Shi, Shouyun Yu
Summary: In this study, a strategy for synthesizing C-heteroaryl glycosides through photoredox catalysis was reported. The method allows for the synthesis of C6-glycosylated phenanthridine derivatives with high selectivity and functional group tolerance.
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Yikuan Liu, Xiaona Liu, An Su, Chengtao Gong, Shenwei Chen, Liwei Xia, Chengwei Zhang, Xiaohuan Tao, Yue Li, Yonghe Li, Tulai Sun, Mengru Bu, Wei Shao, Jia Zhao, Xiaonian Li, Yongwu Peng, Peng Guo, Yu Han, Yihan Zhu
Summary: Covalent organic frameworks are crystalline porous materials with designable structures and functions, which can acquire multifunctionalities and have versatile applications in gas separation/storage, catalysis, and optoelectronic devices.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Heyang Zhang, Jo Vandesompele, Kevin Braeckmans, Stefaan C. De Smedt, Katrien Remaut
Summary: Gene therapy has the potential to revolutionize the treatment of inherited and acquired diseases, but its success rate is currently limited. This review focuses on the obstacles faced by gene therapies in the human body, such as nucleic acid degradation by abundant nucleases, and discusses strategies to reduce degradation and methods to assess nucleic acid integrity.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Chenxi Duan, Chunming Cui
Summary: Low valent group 14 compounds with diazaborolyl substituents exhibit unique structures and reactivity due to the combination of sigma-electron donation and steric hindrance. The modulation of the HOMO-LUMO gap by the diazaborolyl substituents results in novel reaction patterns in the activation of small molecules and inert chemical bonds.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
David E. Salazar Marcano, Nada D. Savic, Kilian Declerck, Shorok A. M. Abdelhameed, Tatjana N. Parac-Vogt
Summary: Metal-oxo clusters have great potential in various fields and can react with biomolecules, making them promising for applications in disease treatment and energy development. They can also be used in the development of inorganic drugs and bioanalytical tools.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Lana K. Moree, Logan A. V. Faulkner, James D. Crowley
Summary: In this tutorial review, the general methods for synthesizing heterometallic metallosupramolecular architectures (MSAs), specifically heterometallic cages, are examined. The intrinsic properties and potential applications of these cages as host-guest systems and reaction catalysts are discussed.
CHEMICAL SOCIETY REVIEWS
(2024)
