期刊
CHEMICAL SOCIETY REVIEWS
卷 47, 期 10, 页码 3543-3557出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cs00154e
关键词
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资金
- European Research Council (Advanced ERC) [ERC-AdG-2012-321295]
- Human Frontier Science Program Long-Term Fellowship
- Uehara Memorial Foundation Research Fellowship
- ETH Zurich Postdoctoral Fellowship
- Marie Curie Actions program
- ETH Zurich
Nanoscale compartments formed by hierarchical protein self-assembly are valuable platforms for nanotechnology development. The well-defined structure and broad chemical functionality of protein cages, as well as their amenability to genetic and chemical modification, have enabled their repurposing for diverse applications. In this review, we summarize progress in the engineering of the cage-forming enzyme lumazine synthase. This bacterial nanocompartment has proven to be a malleable scaffold. The natural protein has been diversified to afford a family of unique proteinaceous capsules that have been modified, evolved and assembled with other components to produce nanoreactors, artificial organelles, delivery vehicles and virus mimics.
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