Visible light-mediated oxidative C(sp(3))-H phosphonylation for alpha-aminophosphonates under oxidant-free conditions

An external oxidant-free synthesis of alpha-aminophosphonates by synergistically combining photocatalysis and proton-reduction catalysis is developed herein. The gram-scale experiment demonstrates the potential utility of this protocol. This study may have important implications for the functionalization of oxidant-sensitive C(sp(3))-H bonds.