A self-assembled peroxidase from 5′-GMP and heme

Guanosine 5 '-monophosphate (5 '-GMP) and Fe(III)-heme form a supramolecular catalyst with peroxidase activity. Catalysis, which depends on self-assembly of 5 '-GMP into a G-quadruplex that binds hemin, can be modulated by nucleotide concentration, temperature and the identity of the nucleotide's sugar.