期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 65, 页码 8944-8959出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc03844a
关键词
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资金
- PRESTO, Japan Science and Technology Agency (JST)
- KAKENHI from the Japan Society for the Promotion of Science (JSPS) [15H03838, 18H02089, 18H04558]
This feature article describes recent progress in synthetic strategies to construct viral capsid-like spherical nanomaterials using the self-assembly of peptides and/or proteins. By mimicking the self-assembly of spherical viral capsids and clathrin, trigonal peptide conjugates bearing beta-sheet-forming peptides, glutathiones, or coiled-coil-forming peptides were developed to construct viral capsid-like particles. beta-Annulus peptides from tomato bushy stunt virus self-assembled into viral capsid-like nanocapsules with a size of 30-50 nm, which could encapsulate various guest molecules and be decorated with different molecules on their surface. Rationally designed fusion proteins bearing symmetric assembling units afforded precise viral capsid-like polyhedral assemblies. These synthetic approaches to construct artificial viruses could become useful guidelines to develop novel drug carriers, vaccine platforms, nanotemplates and nanoreactors.
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