期刊
CHEMCATCHEM
卷 10, 期 9, 页码 1993-1997出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201702037
关键词
alcohols; amines; carbene ligands; hydrogen transfer; iridium
资金
- Japan Society for the Promotion of Science KAKENHI [JP16H01018, 26288047]
- Grants-in-Aid for Scientific Research [26288047, 16H01018] Funding Source: KAKEN
A new catalytic system for the N-monoalkylation of aqueous ammonia with a variety of alcohols was developed. Water-soluble dicationic complexes of iridium bearing N-heterocyclic carbene and diammine ligands exhibited high catalytic activity for this type of reaction on the basis of hydrogen-transfer processes without generating harmful or wasteful byproducts. Various primary amines were efficiently synthesized by using safe, inexpensive, and easily handled aqueous ammonia as a nitrogen source. For example, the reaction of 1-(4-methylphenyl)ethanol with aqueous ammonia in the presence of a water-soluble N-heterocyclic carbene complex of iridium at 150 degrees C for 40h gave 1-(4-methylphenyl)ethylamine in 83% yield.
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