期刊
CEREBRAL CORTEX
卷 28, 期 7, 页码 2577-2593出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhy082
关键词
cortical development; GABAergic interneurons; neurovascular coupling; Vegfa
资金
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/M009424/1]
- BBSRC [BB/M009424/1] Funding Source: UKRI
Vascular endothelial growth factor (Vegfa) is essential for promoting the vascularization of the embryonic murine forebrain. In addition, it directly influences neural development, although its role in the forming forebrain is less well elucidated. It was recently suggested that Vegfa may influence the development of GABAergic interneurons, inhibitory cells with crucial signaling roles in cortical neuronal circuits. However, the mechanism by which it affects interneuron development remains unknown. Here we investigated the developmental processes by which Vegfa may influence cortical interneuron development by analyzing transgenic mice that ubiquitously express the Vegfa120 isoform to perturb its signaling gradient. We found that interneurons reach the dorsal cortex at mid phases of corticogenesis despite an aberrant vascular network. Instead, endothelial ablation of Vegfa alters cortical interneuron numbers, their intracortical distribution and spatial proximity to blood vessels. We show for the first time that vascular-secreted guidance factors promote early-migrating interneurons in the intact forebrain in vivo and identify a novel role for vascular-Vegfa in this process.
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