Constitutive Inactivation of the PRRT2 Gene Alters Short-Term Synaptic Plasticity and Promotes Network Hyperexcitability in Hippocampal Neurons

PRRT2 Regulates Synaptic Fusion by Directly Modulating SNARE Complex Assembly

(2018) Jeff Coleman et al.   Cell Reports

The PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations

(2017) Caterina Michetti et al.   NEUROBIOLOGY OF DISEASE

PRRT2, a network stability gene

(2017) Caterina Michetti et al.   Oncotarget

Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networks

(2017) Davide Lonardoni et al.   PLoS Computational Biology

A Novel Topology of Proline-rich Transmembrane Protein 2 (PRRT2)

(2016) Pia Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+channels

(2016) Pierluigi Valente et al.   JOURNAL OF CELL SCIENCE

Network burst activity in hippocampal neuronal cultures: the role of synaptic and intrinsic currents

(2016) Jyothsna Suresh et al.   JOURNAL OF NEUROPHYSIOLOGY

Network synchronization in hippocampal neurons

(2016) Yaron Penn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRRT2: from Paroxysmal Disorders to Regulation of Synaptic Function

(2016) Flavia Valtorta et al.   TRENDS IN NEUROSCIENCES

PRRT2 Is a Key Component of the Ca 2+ -Dependent Neurotransmitter Release Machinery

(2016) Pierluigi Valente et al.   Cell Reports

The evolving spectrum ofPRRT2-associated paroxysmal diseases

(2015) Darius Ebrahimi-Fakhari et al.   BRAIN

PRRT2 Mutant Leads to Dysfunction of Glutamate Signaling

(2015) Ming Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Severe phenotypic spectrum of biallelic mutations inPRRT2gene

(2015) Marion Delcourt et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Quantification of bursting and synchrony in cultured hippocampal neurons

(2015) Lawrence N. Eisenman et al.   JOURNAL OF NEUROPHYSIOLOGY

Molecular mechanisms of epilepsy

(2015) Kevin Staley   NATURE NEUROSCIENCE

From 2D to 3D: novel nanostructured scaffolds to investigate signalling in reconstructed neuronal networks

(2015) Susanna Bosi et al.   Scientific Reports

Phosphorylation of Synapsin I by Cyclin-Dependent Kinase-5 Sets the Ratio between the Resting and Recycling Pools of Synaptic Vesicles at Hippocampal Synapses

(2014) A. M. J. Verstegen et al.   JOURNAL OF NEUROSCIENCE

Regional Diversity and Developmental Dynamics of the AMPA-Receptor Proteome in the Mammalian Brain

(2014) Jochen Schwenk et al.   NEURON

Parameters for burst detection

(2014) Douglas J. Bakkum et al.   Frontiers in Computational Neuroscience

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability

(2013) Davide Pozzi et al.   EMBO JOURNAL

Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity

(2013) Gabriele Lignani et al.   HUMAN MOLECULAR GENETICS

Role ofPRRT2in common paroxysmal neurological disorders: a gene with remarkable pleiotropy

(2013) Sarah E Heron et al.   JOURNAL OF MEDICAL GENETICS

Altered intrinsic brain activity in patients with paroxysmal kinesigenic dyskinesia by PRRT2 mutation

(2013) ChunYan Luo et al.   NEUROLOGICAL SCIENCES

Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels

(2013) Lucian Medrihan et al.   Nature Communications

Homozygous c.649dupC mutation inPRRT2worsens the BFIS/PKD phenotype with mental retardation, episodic ataxia, and absences

(2012) Angelo Labate et al.   EPILEPSIA

Regulators of synaptic transmission: Roles in the pathogenesis and treatment of epilepsy

(2012) Pablo M. Casillas-Espinosa et al.   EPILEPSIA

Site-Specific Synapsin I Phosphorylation Participates in the Expression of Post-Tetanic Potentiation and Its Enhancement by BDNF

(2012) P. Valente et al.   JOURNAL OF NEUROSCIENCE

The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members

(2012) Markus Sällman Almén et al.   PLoS One

Large-scale, high-resolution electrophysiological imaging of field potentials in brain slices with microelectronic multielectrode arrays

(2012) E. Ferrea et al.   Frontiers in Neural Circuits

Mutations in the Gene PRRT2 Cause Paroxysmal Kinesigenic Dyskinesia with Infantile Convulsions

(2012) Hsien-Yang Lee et al.   Cell Reports

Short-term forms of presynaptic plasticity

(2011) Diasynou Fioravante et al.   CURRENT OPINION IN NEUROBIOLOGY

Network bursts in hippocampal microcultures are terminated by exhaustion of vesicle pools

(2011) Dror Cohen et al.   JOURNAL OF NEUROPHYSIOLOGY

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Exome sequencing identifies truncating mutations in PRRT2 that cause paroxysmal kinesigenic dyskinesia

(2011) Wan-Jin Chen et al.   NATURE GENETICS

Spiking Signatures of Spontaneous Activity Bursts in Hippocampal Cultures

(2011) Alexey Pimashkin et al.   Frontiers in Computational Neuroscience

Hyperactive putamen in patients with paroxysmal kinesigenic choreoathetosis: A resting-state functional magnetic resonance imaging study

(2010) Bo Zhou et al.   MOVEMENT DISORDERS

A comparison of binless spike train measures

(2009) António R. C. Paiva et al.   NEURAL COMPUTING & APPLICATIONS

Low-Frequency Stimulation Induces Stable Transitions in Stereotypical Activity in Cortical Networks

(2008) Ildikó Vajda et al.   BIOPHYSICAL JOURNAL

Opposite Changes in Glutamatergic and GABAergic Transmission Underlie the Diffuse Hyperexcitability of Synapsin I–Deficient Cortical Networks

(2008) Michela Chiappalone et al.   CEREBRAL CORTEX

A novel algorithm for precise identification of spikes in extracellularly recorded neuronal signals

(2008) Alessandro Maccione et al.   JOURNAL OF NEUROSCIENCE METHODS