Article
Engineering, Biomedical
M. Vallet-Regi, A. J. Salinas
Summary: Mesoporous bioactive glasses (MBGs) play an important role in bone regeneration with their outstanding textural properties, quick bioactive responses, and biocompatibility. They can be enhanced by adding small amounts of oxide elements to provide additional biological capacities. MBGs are versatile in various forms and can be further improved by loading with biomolecules, drugs, and stem cells.
MATERIALS TODAY BIO
(2021)
Article
Biochemistry & Molecular Biology
Muhammad Umar Aslam Khan, Saiful Izwan Abd Razak, Sarish Rehman, Anwarul Hasan, Saima Qureshi, Goran M. Stojanovic
Summary: Bone tissue engineering is an advanced approach for treating bone fractures and defects. In this study, polymeric nano-composite scaffolds with different characteristics were prepared and characterized. The scaffolds exhibited different pore morphology and mechanical behavior, and promoted bone mineralization and cell proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biophysics
Banafsheh Safari, Ayuob Aghanejad, Leila Roshangar, Soodabeh Davaran
Summary: Bone tissue engineering is an alternative therapeutic approach that aims to replace lost tissue and restore function by recapitulating the natural regeneration process. By utilizing biocompatible materials, osteoprogenitor/stem cells, and bioactive factors to mimic the bone microenvironment, the goal is to promote bone regeneration effectively.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Ceramics
J. M. Tainio, T. Anttila, J. Pohjola, D. S. Brauer, J. Massera
Summary: Understanding the crystallization mechanism and sintering ability of bioactive glasses is important for their application. This study investigated the crystallization and sintering properties of B12.5 borosilicate glasses containing varying amounts of magnesium and/or strontium. The results showed that the addition of magnesium and strontium facilitated sintering and densification, and the crystallization had unexpected effects on the bioactivity of the glasses.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2024)
Article
Biochemistry & Molecular Biology
Mehdi Azizi, Amin Shavandi, Masoud Hamidi, Shayan Gholizadeh, Mahnaz Mohammadpour, Mohammad Saeid Salami, Hadi Samadian
Summary: Tissue engineering is an innovative approach that combines engineering, biomaterials, and biomedicine to improve conventional bone defect treatment. This study developed bioengineered electroactive and bioactive mineralized carbon nanofibers as a scaffold for bone tissue engineering. The fabricated scaffold showed osteoactivity, electrical conductivity, and biocompatibility, making it an effective solution for bone tissue engineering.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biotechnology & Applied Microbiology
Baoqing Pei, Mengyuan Hu, Xueqing Wu, Da Lu, Shijia Zhang, Le Zhang, Shuqin Wu
Summary: Bone tissue engineering (BTE) is crucial for bone defect repair. Loading bioactive factors into scaffolds allows for controlled release, with scaffold microstructure playing a significant role. This review examines how scaffold microstructure affects the release rate of bioactive factors, with variables including pore size, shape, and porosity. The study concludes that pore size and porosity impact the release rate, providing valuable insights for developing new treatment strategies for bone disease.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Engineering, Biomedical
Adam Shearer, Maziar Montazerian, Jessica J. Sly, Robert G. Hill, John C. Mauro
Summary: At least 25 bioactive glass medical devices have been approved for clinical use worldwide. These devices have diverse applications, including implants, fillers, agents for dentin hypersensitivity, wound dressing, and cancer therapeutics. Bioactive glasses have evolved in morphology and delivery systems, allowing for greater flexibility and control. This article critically discusses the approved products, regulatory standards, and the future development, applications, and challenges of bioactive glasses.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Ceramics
Aylin M. Deliormanli, Mertcan Ensoylu, Ghada ALMisned, H. O. Tekin
Summary: In this study, polycaprolactone (PCL) and polylactide-co-glycolide (PLGA) coated bioactive glass scaffolds containing molybdenum disulfide (MoS2) nanoparticles were prepared and evaluated for their usability in bone tissue engineering applications. The results showed that the presence of MoS2 nanoparticles in the polymer matrix improved the mechanical properties of the scaffolds and increased the hydroxyapatite-forming ability of the bioactive glass-based composites. Additionally, the composite scaffolds demonstrated high radiation-shielding ability due to the presence of MoS2 nanoparticles.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Biomedical
Elisa Fiume, Alessandro Schiavi, Gissur Orlygsson, Cristina Bignardi, Enrica Verne, Francesco Baino
Summary: Proper microstructural and transport properties are crucial for scaffold design in tissue engineering applications. Evaluating permeability remains a challenge, while pore characteristics are relatively easier to assess.
ACTA BIOMATERIALIA
(2021)
Review
Engineering, Biomedical
Kai Zheng, Wen Niu, Bo Lei, Aldo R. Boccaccini
Summary: The regulatory functions of immune response in tissue regeneration, ways to modulate immune cell responses (especially macrophages), and the potential of bioactive glasses in bone regeneration and wound healing have been recognized. Understanding the immunomodulatory effects of BGs and the interactions with immune cells are crucial for enhancing tissue regeneration. Emerging research focuses on harnessing macrophage responses through active ions, surface functionalization, and controlled release of immunomodulatory agents for improved tissue regeneration.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Chemical
Itay Zusmanovitch, Thabet Asbi, Oshrat Regev, Hadar Zigdon Giladi, Havazelet Bianco-Peled
Summary: The study aimed to create an improved scaffold for bone tissue engineering that meets the requirements of cells, cytokines, and mechanical demands. By using an integrative approach and considering crucial design criteria, such as high porosity, a wide range of pore sizes, a hydrophilic and rough surface, and biofunctionalization, polycaprolactone (PCL) was chosen as the scaffold material and its bioactivity was improved using various methods. The thoroughly characterized scaffolds demonstrated enhanced cell adhesion and proliferation, as well as high hydrophilicity, high porosity with interconnected pores, stiffness, and improved bioactivity compared to other studied scaffolds, making them a promising platform for bone engineering.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Engineering, Biomedical
Lidong Huang, Weiyu Gong, Guibin Huang, Jingyi Li, Jilin Wu, Yuguang Wang, Yanmei Dong
Summary: This study explored the effects of photobiomodulation (PBM) combined with bioactive glass (BG) on early angiogenesis. The results showed that the combination of PBM and BG significantly promoted endothelial cell proliferation, gene expression, and tubule formation. In vivo experiments confirmed that PBM induced early angiogenesis, with more vascular-like structures observed in the BG + PBM group.
BIOMEDICAL MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Elisa Batoni, Amedeo Franco Bonatti, Carmelo De Maria, Kenneth Dalgarno, Raasti Naseem, Umberto Dianzani, Casimiro Luca Gigliotti, Elena Boggio, Giovanni Vozzi
Summary: This work presents a computational model to study the degradation behavior of functionalized polyester-based 3D scaffolds for bone regeneration. A 3D-printed scaffold presenting a functionalized surface with a bioactive protein was investigated as a case study. The aim of the model was to optimize the scaffold design to control degradation and protein release over time and space. Two scenarios, with and without macroporosity, were considered.
Article
Biochemistry & Molecular Biology
Esmat Azizipour, Hossein Aghamollaei, Raheleh Halabian, Delaram Poormoghadam, Mostafa Saffari, Maliheh Entezari, Ali Salimi
Summary: Employing hydrogels with bioactive glass nanowhiskers for bone tissue repair showed successful induction of hMSCs differentiation into osteogenic lineage and biomineralization. Cell viability assays confirmed biocompatibility and increased proliferation with BGnW incorporation. Molecular investigations revealed elevated osteogenic markers level, suggesting Gel-Glu-Col/BGnW as a potential candidate for bone tissue regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Ceramics
Sanam Mohandesnezhad, Mahdieh Hajian Monfared, Saeed Samani, Ali Farzin, S. Ali Poursamar, Jafar Ai, Somayeh Ebrahimi-Barough, Mahmoud Azami
Summary: In this study, scaffolds based on chitosan/Alginate/Hardystonite (Cs/Alg/HD) were developed for bone tissue engineering. Well-ordered porous scaffolds were prepared with four compositions of Cs/Alg/HD using direct ink writing 3D printing technique. The results showed that CsAlg-HD70 had the highest yield strength (1.38 MPa) and elastic modulus (125.71 MPa), as well as the highest degradation rate and bioactivity. The addition of HD particles also had a positive effect on cell viability and attachment, with CsAlg-HD40 reaching a cell viability of 150% on the 7th day. The study concluded that scaffolds prepared from Cs/Alg and HD may be a promising alternative for bone tissue engineering.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)