期刊
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
卷 45, 期 1, 页码 291-300出版社
KARGER
DOI: 10.1159/000486810
关键词
25-hydroxyvitamin D; Gestational diabetes; Meta-analysis
资金
- National Key Basic Research Program of China [2013CB530604]
- National Natural Science Foundation of China [81600685, 81402147]
- Natural Science Foundation of Jiangsu Province [BK20160141]
- Medical Science and technology development Foundation of Nanjing Department of Health [YKK16201]
- Science and Technology Development Fund of the Nanjing Medical University [2015NJMUZD062]
- Changzhou Natural Science Foundation [CJ20140021]
- Jiangsu Provincial Medical Youth Talent [QNRC2016304]
Background/Aims: Whether maternal vitamin D deficiency is associated with gestational diabetes remains controversial. This meta-analysis aimed to systematically evaluate published evidence on the association between maternal vitamin D status and the risk of gestational diabetes. Methods: We retrieved relevant articles from the PubMed, Medline and Embase databases up to May 2017 for observational studies investigating the association between vitamin D status and the risk of gestational diabetes. Odds ratios (OR) or risk ratios (RR) from individual studies were pooled using the fixed and random effect models. Results: The meta-analysis of 29 observational studies included 28,982 participants, of which 4,634 were diagnosed with gestational diabetes, and showed that maternal vitamin D insufficiency was associated with a significantly increased risk of gestational diabetes by 39% (pooled OR = 1.39, 95% CI = 1.20-1.60) with moderate heterogeneity (I (2) = 50.2%; P = 0.001). Moreover, the 25(OH) D level was significantly lower in gestational diabetes cases than in controls with a pooled effect of -4.79 nmol/L (95% CI = -6.43, -3.15). Significant heterogeneity was also detected (I (2) = 65.0%, P < 0.001). Further subgroup analysis indicated that this association was also evident in most subpopulations. Conclusion: This meta-analysis indicated a significant association between vitamin D insufficiency and increased risk of gestational diabetes. Further well-designed large-scale clinical trials are essential to verify this association. (C) 2018 The Author(s) Published by S. Karger AG, Basel
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