Review
Immunology
Kilian Kelly, John E. J. Rasko
Summary: GvHD is a life-threatening complication of hematopoietic stem cell transplantation, often requiring high-dose corticosteroid treatment. MSCs show promise as a potential therapy due to their immunosuppressive and immunoregulatory effects, but their efficacy may be influenced by donor variability and manufacturing processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Andreas Kreft, Katrin Hippe, Eva Maria Wagner-Drouet, Isabelle Ries, Arne Kandulski, Maike Buettner-Herold, Helmut Neumann, Daniela Weber, Ernst Holler, Mario Schindeldecker
Summary: Multiple simultaneous colon biopsies improve diagnostic sensitivity in patients with acute graft versus host disease (aGvHD). Higher histological grades are associated with steroid therapy initiation and refractoriness, particularly when advanced damage is present in all samples. The Lerner system is generally superior to other grading methods for predicting treatment response and outcome.
Article
Biochemistry & Molecular Biology
Andrei Mircea Vacaru, Ana-Maria Mazilu, Madalina Dumitrescu, Ioana Madalina Fenyo, Anca Violeta Gafencu, Ana-Maria Vacaru
Summary: This study found that treatment with FasL-overexpressing MSC can improve GvHD and increase survival in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Mariella Lo Schirico, Roberto Passera, Jessica Gill, Chiara Dellacasa, Irene Dogliotti, Luisa Giaccone, Sofia Zompi, Alessandro Busca
Summary: The use of 5 mg/kg of rabbit antilymphocyte serum (ATG/ATLG) as GVHD prophylaxis in transplantation patients is highly effective in reducing the incidence of both acute and chronic GVHD, as well as non-relapse mortality, relapse incidence, and infection occurrence.
Review
Immunology
Makoto Murata, Takanori Teshima
Summary: This article discusses the potential of MSC therapy in the treatment of acute GVHD, along with a comparison of studies on the two products, Remestemcel-L and Temcell. While Temcell's real-world efficacy was found to be equivalent to that observed in a prospective study, the precise position of Remestemcel-L/Temcell therapy in the treatment of acute GVHD remains to be determined.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
J. Bolanos-Meade, M. Hamadani, J. Wu, M. M. Al Malki, M. J. Martens, L. Runaas, H. Elmariah, A. R. Rezvani, M. Gooptu, K. T. Larkin, B. C. Shaffer, N. El Jurdi, A. W. Loren, M. Solh, A. C. Hall, A. M. Alousi, O. H. Jamy, M. -A. Perales, J. M. Yao, K. Applegate, A. S. Bhatt, L. S. Kean, Y. A. Efebera, R. Reshef, W. Clark, N. L. DiFronzo, E. Leifer, M. M. Horowitz, R. J. Jones, S. G. Holtan
Summary: This study compared the efficacy of two prophylaxis regimens for graft-versus-host disease (GVHD) in patients with hematologic cancers. The results showed that patients receiving cyclophosphamide-tacrolimus-mycophenolate mofetil had significantly higher GVHD-free, relapse-free survival at 1 year compared to those receiving tacrolimus-methotrexate.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Immunology
Sumedha Pareek, Alexandra S. Flegle, Drew Boagni, Jin Yong Kim, Dohyun Yoo, Abel Trujillo-Ocampo, Sung-Eun Lee, Mao Zhang, Sangyong Jon, Jin S. Im
Summary: This study found that post-transplantation treatment with bilirubin nanoparticles (BRNP) can reduce the occurrence of graft versus host disease (GVHD). BRNP can alleviate tissue damage, reduce inflammation, and regulate immune responses, thereby improving the clinical manifestations and survival rates of GVHD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Andrea Maria Novaes Machado, Morgani Rodrigues, Helena Malvezzi, Carla de Azevedo Piccinato, Nelson Hamerschlak, Sergio Podgaec
Summary: The study found that approximately one-third of females undergoing HSCT develop genital GVHD, emphasizing the importance of early detection and treatment.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Review
Pediatrics
Maria Tsimeki, Antonios Tsimpidakis, Stella Roidi, Themos Gregoriadis, Alexandra Soldatou, Vasiliki Kitra, Lina Michala
Summary: This study provides a systematic literature review of genital GVHD in girls and adolescents post HSCT, suggesting early pediatric gynecologic examination within the first year after HSCT for early diagnosis and treatment initiation.
Article
Immunology
Thomas Krueger, Rebekka Wehner, Maik Herbig, Martin Kraeter, Michael Kramer, Jan Moritz Middeke, Friedrich Stoelzel, Catrin List, Katharina Egger-Heidrich, Raphael Teipel, Uta Oelschlaegel, Martin Wermke, Helena Jambor, Manja Wobus, Johannes Schetelig, Korinna Joehrens, Torsten Tonn, Julien Subburayalu, Marc Schmitz, Martin Bornhauser, Malte von Bonin
Summary: Functional impairment of the bone marrow niche, particularly a decrease in mesenchymal stromal cells (MSCs), is associated with cytopenia and graft failure after hematopoietic cell transplantation. Acute graft-versus-host disease (aGvHD) is shown to significantly reduce MSC numbers, and this reduction can be observed before clinical onset of aGvHD. The different phenotypic and functional characteristics of MSCs depending on the occurrence of aGvHD suggest that they may contribute to alloreactivity after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Xiang Shu, Qin Zhou, Xiaohui Sun, Michelle Flesaker, Xingyi Guo, Jirong Long, Mark E. Robson, Xiao-Ou Shu, Wei Zheng, Jonine L. Bernstein
Summary: This study identified 98 proteins that may have potential causal associations with the risk of breast cancer subtypes. The associations of ICAM1, PLA2R1, and TXNDC12 varied significantly across the subtypes. These findings contribute to understanding the heterogeneity in the etiology of different subtypes of breast cancer and may aid in personalized risk assessment of the disease.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Robert B. Levy, Hazem M. Mousa, Casey O. Lightbourn, Eric J. Shiuey, David Latoni, Stephanie Duffort, Ryan Flynn, Jing Du, Henry Barreras, Michael Zaiken, Katelyn Paz, Bruce R. Blazar, Victor L. Perez
Summary: Graft versus host disease (GVHD) is a complication of stem cell transplants, and ocular involvement occurs in a high percentage of patients. This study found a correlation between ocular and cutaneous involvement in chronic GVHD, suggesting shared immune mechanisms. Evaluating the ocular surface in patients with skin involvement may be valuable.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hui Li, Qi Liu, Xiaofeng Gao, Di Zhang, Shengjun Mao, Yongqian Jia
Summary: The study explored the potential of human umbilical mesenchymal stem cells transfected with IFN-γ gene and found that this treatment significantly reduced the incidence and severity of GVHD in vivo, providing a significant survival benefit.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Immunology
Carina A. Baeuerlein, Musga Qureischi, Zeinab Mokhtari, Paula Tabares, Christian Brede, Ana-Laura Jordan Garrote, Simone S. Riedel, Martin Chopra, Simone Reu, Anja Mottok, Estibaliz Arellano-Viera, Carolin Graf, Miriam Kurzwart, Katharina Schmiedgen, Hermann Einsele, Matthias Woelfl, Paul-Gerhardt Schlegel, Andreas Beilhack
Summary: Research suggests that the upregulation of alpha 4 beta 7 integrin, CD162E, CD162P, and downregulation of CD62L on peripheral blood T-cells may be correlated with the development of aGvHD after allo-HCT. Other surface markers like CD25, CD69, and CC-chemokine receptors were not found to be predictive markers in this study. Based on preclinical data from mouse models, a panel of surface markers combining alpha 4 beta 7 integrin with CD62L, CD162E, and CD162P is proposed to identify patients at risk for early aGvHD after allo-HCT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Jemma Nicholls, Benjamin Cao, Laetitia Le Texier, Laura Yan Xiong, Christopher R. Hunter, Genesis Llanes, Ethan G. Aguliar, Wayne A. Schroder, Simon Phipps, Jason P. Lynch, Huimin Cao, Shen Y. Heazlewood, Brenda Williams, Andrew D. Clouston, Christian M. Nefzger, Jose M. Polo, Susan K. Nilsson, Bruce R. Blazar, Kelli P. A. MacDonald
Summary: BM-Treg and pTreg exhibit distinct characteristics, including differential expression of chemokine receptors, transcription factors, and cell cycle control genes. BM-Treg show unique properties and are functionally and phenotypically different from splenic Treg.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xue Li, Yihui Wu, Chenghao Shen, Tatyana Y. Belenkaya, Lorraine Ray, Xinhua Lin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Cell Biology
Ying Feng, Xue Li, Lorraine Ray, Haiyun Song, Jia Qu, Shuyong Lin, Xinhua Lin
CELLULAR SIGNALLING
(2014)
Article
Cell Biology
Lanlan Zha, Xue Li, Xiangyu Meng, Yuanlin Liu, Weijiang Liu, Yang Wang, Yue Fan, Bin Zhou, Pei Li, Rongxiu Zheng, Yi Zhang
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Cell Biology
Na Zhou, Weijiang Liu, Wei Zhang, Yuanlin Liu, Xue Li, Yang Wang, Rongxiu Zheng, Yi Zhang
Summary: This study reveals the crucial role of Wip1 in modulating the immunosuppressive capacities of MSCs in T1DM mice, showing that Wip1(-/-)MSCs have weaker therapeutic effects and immunosuppressive capabilities. The findings suggest that Wip1 is essential for regulating the immunomodulation properties of MSCs in T1DM treatment.
CELL DEATH DISCOVERY
(2021)