期刊
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
卷 45, 期 3, 页码 993-1002出版社
Cell Physiol Biochem Press GmbH & Co
DOI: 10.1159/000487294
关键词
Gal-9; Prognosis; Solid tumour; Meta-analysis
资金
- Natural Science Foundation of Jiangsu Province [BK20141161, BK20150251]
Background/Aims: Recently, many studies have demonstrated that galectin-9 (Gal-9) exhibits altered expression and has a close association with metastasis and recurrence in various cancers. Therefore, we conducted a meta-analysis to assess the prognostic role of Gal-9 expression in solid tumours. Methods: We searched PubMed, Embase, and Web of Science until June 2017 and identified fourteen eligible studies containing 2,408 patients to include in the meta-analysis. Results: The pooled results indicated that higher Gal-9 expression in cancer tissue associated with an improved CSS (HR = 0.48, 95% CI 0.39-0.58). In the subgroup analysis, a significant relationship was observed between higher Gal-9 expression and both CSS (HR = 0.48, 95% CI 0.39-0.59) and OS (HR = 0.62, 95% CI 0.49-0.78) in digestive cancers. Conclusions: The findings of this meta-analysis highlight the role of Gal-9 as a useful clinical prognostic biomarker, which may facilitate the treatment of patients with solid tumours. (C) 2018 The Author(s) Published by S. Karger AG, Basel
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