Review
Physiology
Corey Wittig, Robert Szulcek
Summary: This review explores how the ratios of ECM proteins change in cardiovascular diseases and the aged individuum, with a focus on collagen-I, collagen-III, and elastin. The study reveals a tendency for increased collagen-I/collagen-III and decreased elastin/collagen ratios in cardiovascular diseases, highlighting the potential implications for pathological states and differences between human heart and aortic ECM protein ratios.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cell Biology
Akiko Mammoto, Kienna Matus, Tadanori Mammoto
Summary: The aging population is rapidly increasing, with arterial aging leading to various age-related pathologies such as cardiovascular diseases. Age-related changes in the aortic wall affect stable circulation and lead to organ dysfunction. Remodeling of the extracellular matrix is a hallmark of aortic functional stiffening in aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiao Lu, Greg Kelley, Mengjun Wang, Xiaomei Guo, Ling Han, Ghassan S. Kassab
Summary: This study evaluates the chronic performance of bovine pulmonary visceral pleura (PVP) as bioprosthetic valve cusps. The results show that PVP cusps have suitable mechanical strength and biocompatibility.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Amadeus S. Zhu, Tasneem Mustafa, Jennifer P. Connell, K. Jane Grande-Allen
Summary: Mitral valve disease is a common cardiovascular condition characterized by fibrotic remodeling. In this study, it was found that pro-inflammatory cytokines TNF-alpha and IL-1 beta can downregulate myofibroblast differentiation in mitral VICs via the NF-kappa B signaling pathway, suggesting potential new avenues for pharmaceutical treatments for mitral valve disease.
ACTA BIOMATERIALIA
(2021)
Article
Cardiac & Cardiovascular Systems
Hannah J. Riley, Ryan R. Kelly, An O. Van Laer, Lily S. Neff, Shaoni Dasgupta, Catalin F. Baicu, Lindsay T. McDonald, Amanda C. LaRue, Michael R. Zile, Amy D. Bradshaw
Summary: In this study, it was demonstrated in a murine model of cardiac fibrosis induced by LVPO that SPARC expression by bone marrow-derived cells is critical for driving cardiac fibrosis and increasing cardiac macrophages. The findings suggest that SPARC plays a key role in fibrotic deposition of collagen and expansion of myocardial macrophages in response to chronic pressure overload.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sana Nasim, Popular Pandey, Rosemeire M. Kanashiro-Takeuchi, Jin He, Joshua D. Hutcheson, Lidia Kos
Summary: The study demonstrates the importance of pigmentation in organizing elastic fibers and dictating biomechanical properties of the aortic valve in mice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ki Wung Chung, Seh Hyon Song, Man-seok Kim
Summary: The study demonstrated that a mixture of amino acids and copper ions significantly increased the expression of genes and proteins related to ECM in human dermal fibroblasts. Copper ions dose-dependently increased gene expression of elastin and collagen I, while the amino acid-Cu2+ mixture enhanced protein expression of these components. Furthermore, the synergistic effects of amino acids and copper ions on ECM protein synthesis in dermal fibroblasts were highlighted in the results.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Engineering, Biomedical
Xiaodan Shi, Song Zhang, Yue Liu, Bryn Brazile, Jim Cooley, J. Ryan Butler, Sara R. McMahan, Karla L. Perez, Jiazhu Xu, Timothy Eastep, Kytai T. Nguyen, Pietro Bajona, Matthias Peltz, Huajian Gao, Yi Hong, Jun Liao
Summary: Cardiac extracellular matrices, particularly elastin, play important roles in cardiac mechanics. This study investigated the distribution and morphology of cardiac elastin in porcine left ventricles. The results showed location-dependent and depth-dependent epicardial elastin network, a thicker endocardial layer with higher elastin-collagen ratio and denser elastin fiber network, and the presence of elastin fibers in myocardial interstitium connecting cardiomyocyte bundles. The collagen-elastin combination provides mechanical strength and facilitates elastic recoil. The association between elastin fibers and Purkinje cells suggests a protective role during deformations. This study provides a structural basis for further biomechanical investigations and biomimicking of cardiac ECM.
BIOACTIVE MATERIALS
(2023)
Article
Dermatology
Aniqa Chowdhury, Nasim Nosoudi, Saketh Karamched, Vaideesh Parasaram, Naren Vyavahare
Summary: The combination of polyphenols with short exposure to UVA light can increase extracellular matrix deposition of elastin and collagen, potentially improving skin properties.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Chrysostomi Gialeli, Annelie Shami, Isabel Goncalves
Summary: Recent studies have highlighted the critical role of ECM and its main binding partners in driving the development and destabilization of atherosclerotic plaques. Key findings include the impact of PGs-GAGs synthesis, elastin synthesis, and plaque collagen structure on disease progression, offering potential therapeutic interventions and diagnostic imaging targets. The growing acknowledgment of the importance of studying the ECM in atherosclerosis has led to the development of various systems to visualize, target, and mimic its functions.
CURRENT OPINION IN LIPIDOLOGY
(2021)
Review
Medicine, General & Internal
Javier Martin-Lopez, Consuelo Perez-Rico, Selma Benito-Martinez, Barbara Perez-Kohler, Julia Bujan, Gemma Pascual
Summary: Pterygium is a complex and multifactorial fibrovascular lesion attributed to sun exposure to ultraviolet-B radiation. Studies have shown that changes in collagen and elastic fibers occur in pterygium, suggesting dysregulation in the synthesis and crosslinking of the fibroelastic component as an important pathogenetic mechanism for the disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Juergen Becker, Sonja Schwoch, Christina Zelent, Maren Sitte, Gabriela Salinas, Joerg Wilting
Summary: Lymphedema is a chronic disease affecting millions globally, with no pharmacological treatment available. The disease is characterized by swelling, fibrosis, and collagen accumulation in affected tissues. This study found that hypoxia may contribute to fibrosis in lymphatic endothelial cells (LECs), with hypoxic LECs showing a high ability to alter the extracellular matrix.
Article
Multidisciplinary Sciences
Eijiro Maeda, Yoriko Ando, Kazuhiro Takeshita, Takeo Matsumoto
Summary: This study used tissue clearing method to successfully observe changes in the structure of the three primary components of rat thoracic aorta, and found that the deformation of elastic fibers and smooth muscle cells was greater on the intimal side.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Gregory Halsey, Dipasha Sinha, Saphala Dhital, Xiaoying Wang, Naren Vyavahare
Summary: Elastin is a crucial protein that provides structural integrity to tissues by forming elastic fibers. The degradation of elastic fibers is linked to the manifestation and pathogenesis of various diseases. Stabilizing elastic fiber structures and repairing lost elastin may be effective strategies to reverse the effects of these diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Riyuan Wang, Yuancheng Wang, Jianxin Song, Huanhuan Tan, Chi Tian, Dongchao Zhao, Sheng Xu, Ping Zhao, Qingyou Xia
Summary: In this study, a novel method of screening targeted therapeutic peptides in natural proteins was established, with details provided for library construction, transcription assays, receptor selection, therapeutic peptide screening, and biological activity analysis. This method successfully screened the therapeutic peptides TS263 and TS1000, which have the ability to specifically promote the synthesis of the extracellular matrix. We believe that this method provides a reference for screening other drugs in natural resources, including proteins, peptides, fats, nucleic acids, and small molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)