The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1–IRF3 signaling

Regulation of type I interferon signaling in immunity and inflammation: A comprehensive review

(2017) Kun Chen et al.   JOURNAL OF AUTOIMMUNITY

Arginine Methylation: The Coming of Age

(2017) Roméo S. Blanc et al.   MOLECULAR CELL

Arginine methyltransferases in normal and malignant hematopoiesis

(2016) Sarah M. Greenblatt et al.   EXPERIMENTAL HEMATOLOGY

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes

(2016) Liu-Ting Chen et al.   JOURNAL OF IMMUNOLOGY

cFLIPLInterrupts IRF3–CBP–DNA Interactions To Inhibit IRF3-Driven Transcription

(2016) Lauren T. Gates et al.   JOURNAL OF IMMUNOLOGY

S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3

(2016) Fuan Wang et al.   NATURE IMMUNOLOGY

Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

(2016) Xia Li et al.   NATURE IMMUNOLOGY

Protein arginine methylation/demethylation and cancer

(2016) Coralie Poulard et al.   Oncotarget

Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis

(2015) Fan Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone Arginine Methylation by PRMT7 Controls Germinal Center Formation via RegulatingBcl6Transcription

(2015) Zhengzhou Ying et al.   JOURNAL OF IMMUNOLOGY

The tumor suppressor PTEN has a critical role in antiviral innate immunity

(2015) Shun Li et al.   NATURE IMMUNOLOGY

PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents

(2015) Makoto Nakakido et al.   Oncotarget

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

(2014) Delphine Goubau et al.   NATURE

Non-histone protein methylation as a regulator of cellular signalling and function

(2014) Kyle K. Biggar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A gain-of-function mouse model identifies PRMT6 as a NF-κB coactivator

(2014) Alessandra Di Lorenzo et al.   NUCLEIC ACIDS RESEARCH

Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation

(2013) Weilin Chen et al.   CELL

Protein arginine methylation of non-histone proteins and its role in diseases

(2013) Han Wei et al.   CELL CYCLE

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation

(2013) Ailan Guo et al.   MOLECULAR & CELLULAR PROTEOMICS

Innate immune detection of microbial nucleic acids

(2013) Claudia Gürtler et al.   TRENDS IN MICROBIOLOGY

PPM1B negatively regulates antiviral response via dephosphorylating TBK1

(2012) Yanling Zhao et al.   CELLULAR SIGNALLING

TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1

(2012) Meng Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Method for Large-scale Identification of Protein Arginine Methylation

(2012) Thomas Uhlmann et al.   MOLECULAR & CELLULAR PROTEOMICS

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

(2012) Jun Cui et al.   NATURE IMMUNOLOGY

Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor

(2012) Mathieu Neault et al.   NUCLEIC ACIDS RESEARCH

p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6

(2012) Sameer Phalke et al.   NUCLEIC ACIDS RESEARCH

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

(2011) Xingguang Liu et al.   NATURE IMMUNOLOGY

Methylation of H2AR29 is a novel repressive PRMT6 target

(2011) Tanja Waldmann et al.   Epigenetics & Chromatin

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Arginine methylation of the B cell antigen receptor promotes differentiation

(2010) Simona Infantino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-β Production

(2010) Joan Ní Gabhann et al.   JOURNAL OF IMMUNOLOGY

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

(2009) Chen Wang et al.   NATURE IMMUNOLOGY

Glucocorticoids Inhibit IRF3 Phosphorylation in Response to Toll-like Receptor-3 and -4 by Targeting TBK1 Activation

(2008) Claire E. McCoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE