DNA methylation rather than single nucleotide polymorphisms regulates the production of an aberrant splice variant of IL6R in mastitic cows

Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice

(2016) Volodymyr P. Tryndyak et al.   BMC GENOMICS

Changes in genetic selection differentials and generation intervals in US Holstein dairy cattle as a result of genomic selection

(2016) Adriana García-Ruiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes

(2016) Terri L. Messier et al.   Oncotarget

Combined analysis of DNA methylome and transcriptome reveal novel candidate genes with susceptibility to bovine Staphylococcus aureus subclinical mastitis

(2016) Minyan Song et al.   Scientific Reports

Innate and Adaptive Immunity Synergize to Trigger Inflammation in the Mammary Gland

(2016) Pascal Rainard et al.   PLoS One

Control of Bovine Mastitis: Old and Recent Therapeutic Approaches

(2015) Fernanda Gomes et al.   CURRENT MICROBIOLOGY

The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition

(2015) Christoph Garbers et al.   CURRENT OPINION IN IMMUNOLOGY

The varying faces of IL-6: From cardiac protection to cardiac failure

(2015) Jillian A. Fontes et al.   CYTOKINE

Genetic mutations potentially cause two novel NCF1 splice variants up-regulated in the mammary gland, blood and neutrophil of cows infected by Escherichia coli

(2015) Zijing Zhang et al.   MICROBIOLOGICAL RESEARCH

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

The alternative role of DNA methylation in splicing regulation

(2015) Galit Lev Maor et al.   TRENDS IN GENETICS

Epigenetic mechanisms contribute to enhanced expression of immune response genes in the liver of cows after experimentally induced Escherichia coli mastitis

(2015) Guangjun Chang et al.   VETERINARY JOURNAL

Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis

(2015) Maria Lopez-Lasanta et al.   ARTHRITIS RESEARCH & THERAPY

Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond

(2015) Achim Breiling et al.   Epigenetics & Chromatin

Soluble IL6R represents a miR-34a target: potential implications for the recently identified IL-6R/STAT3/miR-34a feed-back loop

(2015) Huihui Li et al.   Oncotarget

HP1 Is Involved in Regulating the Global Impact of DNA Methylation on Alternative Splicing

(2015) Ahuvi Yearim et al.   Cell Reports

Role of an SNP in Alternative Splicing of Bovine NCF4 and Mastitis Susceptibility

(2015) Zhihua Ju et al.   PLoS One

iTRAQ-proteomics and bioinformatics analyses of mammary tissue from cows with clinical mastitis due to natural infection with Staphylococci aureus

(2014) Jinming Huang et al.   BMC GENOMICS

A SNP in intron 8 of CD46 causes a novel transcript associated with mastitis in Holsteins

(2014) Xiuge Wang et al.   BMC GENOMICS

Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer

(2014) Xiaojing Yang et al.   CANCER CELL

TLR2 Promoter Hypermethylation Creates Innate Immune Dysbiosis

(2014) M. Benakanakere et al.   JOURNAL OF DENTAL RESEARCH

Association of TNP2 Gene Polymorphisms of the bta-miR-154 Target Site with the Semen Quality Traits of Chinese Holstein Bulls

(2014) Qing Gao et al.   PLoS One

SR proteins control a complex network of RNA-processing events

(2014) Todd Bradley et al.   RNA

Caveolin-1, Through its Ability to Negatively Regulate TLR4, is a Crucial Determinant of MAPK Activation in LPS-challenged Mammary Epithelial Cells

(2013) Xiao-Xi Wang et al.   Asian Pacific Journal of Cancer Prevention

The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro

(2013) Anna Lewandowska-Sabat et al.   BMC GENOMICS

Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition

(2013) Alika K Maunakea et al.   CELL RESEARCH

Chromatin’s thread to alternative splicing regulation

(2013) Camilla Iannone et al.   CHROMOSOMA

Aberrant promoter methylation of the CD4 gene in peripheral blood cells of mastitic dairy cows

(2013) X.S. Wang et al.   GENETICS AND MOLECULAR RESEARCH

DNA methylation contributes to natural human variation

(2013) H. Heyn et al.   GENOME RESEARCH

Enhanced IL-6/IL-6R Signaling Promotes Growth and Malignant Properties in EBV-Infected Premalignant and Cancerous Nasopharyngeal Epithelial Cells

(2013) Guitao Zhang et al.   PLoS One

Multiple promoters and targeted microRNAs direct the expressions ofHMGB3gene transcripts in dairy cattle

(2012) Liming Li et al.   ANIMAL GENETICS

Asthma Discordance in Twins Is Linked to Epigenetic Modifications of T Cells

(2012) R. Scott Runyon et al.   PLoS One

In depth analysis of genes and pathways of the mammary gland involved in the pathogenesis of bovine Escherichia coli- mastitis

(2011) Bart Buitenhuis et al.   BMC GENOMICS

Identification of Splice Variants, Targeted MicroRNAs and Functional Single Nucleotide Polymorphisms of the BOLA-DQA2 Gene in Dairy Cattle

(2011) Qinlei Hou et al.   DNA AND CELL BIOLOGY

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

(2011) Simon A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunopathology of Mastitis: Insights into Disease Recognition and Resolution

(2011) Stacey L. Aitken et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Inflammatory Processes Triggered by Helicobacter pylori Infection Cause Aberrant DNA Methylation in Gastric Epithelial Cells

(2010) T. Niwa et al.   CANCER RESEARCH

Comparative Kinetics ofEscherichia coli- andStaphylococcus aureus-Specific Activation of Key Immune Pathways in Mammary Epithelial Cells Demonstrates ThatS. aureusElicits a Delayed Response Dominated by Interleukin-6 (IL-6) but Not by IL-1A or Tumor Necrosis Factor Alpha

(2010) Juliane Günther et al.   INFECTION AND IMMUNITY

Genetic analysis of mastitis data with different models

(2010) D. Hinrichs et al.   JOURNAL OF DAIRY SCIENCE