Article
Geriatrics & Gerontology
Huang-Chun Liu, Der-Sheng Han, Chih-Chin Hsu, Jong-Shyan Wang
Summary: This study suggests that circulating myo-miRNA (c-miR-486) and inflammation-related miRNA (c-miR-146a) may serve as superior biomarkers for age-related sarcopenia compared to inflammatory peroxide and cytokines in plasma.
Article
Endocrinology & Metabolism
Mengqi Zhang, Haojun Yang, Zhuohui Chen, Xinhang Hu, Tong Wu, Weiping Liu
Summary: The study revealed that long noncoding RNA XIST promotes the secretion of inflammatory cytokines in LPS-treated CTX-TNA2 cells by sponging miR-29c-3p and regulating NFAT5 expression. Silencing XIST expression or increasing miR-29c-3p expression can inhibit the secretion of inflammatory factors and promote the transport of glutamate in LPS-treated CTX-TNA2 cells.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Immunology
Hiroyuki Oshiumi
Summary: Vaccination is the best way to prevent infectious diseases, but vaccine efficacy and adverse reactions vary among individuals. miRNAs in serum EVs can regulate immune responses and vaccine efficacy, such as miR-192 and miR-21. EV miRNAs can be used as tools to improve vaccine efficacy and predict immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Sharif Moradi, Esmaeil Jarrahi, Ali Ahmadi, Jafar Salimian, Mehrdad Karimi, Azadeh Zarei, Sadegh Azimzadeh Jamalkandi, Mostafa Ghanei
Summary: Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by airway inflammation and progressive lung airflow obstruction. Research on the PI3K signaling pathway has shown promising outcomes for developing new anti-COPD drugs, as it plays a crucial role in COPD development and exacerbations. The inhibition of the PI3K signaling pathway has shown potential therapeutic benefits in both preclinical animal models and human clinical trials.
JOURNAL OF PATHOLOGY
(2021)
Review
Sport Sciences
William S. Evans, Ryan M. Sapp, Katherine I. Kim, James M. Heilman, James Hagberg, Steven J. Prior
Summary: This article discusses the benefits of exercise training on cardiovascular health and the role of circulating angiogenic cells in these changes. It emphasizes the essential function of secreted factors from these cells in maintaining cardiovascular health and summarizes the findings of studies on the effects of exercise training on these factors.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2021)
Article
Environmental Sciences
Yu Shang, Qianyun Liu, Lu Wang, Xinghua Qiu, Yingjun Chen, Jing An
Summary: This study investigates the role of miR-146a-5p in regulating cytokine expression in response to PM2.5 exposure, and finds that autophagy process plays a crucial role in modulating cytokine expression and inflammatory response caused by PM2.5.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Budhaditya Mukherjee, Kamalika Mukherjee, Piyush Nanda, Rupkatha Mukhopadhayay, V. Ravichandiran, Suvendra N. Bhattacharyya, Syamal Roy
Summary: Visceral leishmaniasis caused by Leishmania donovani can develop resistance to pentavalent antimonial drugs, leading to more aggressive infection in mammals. Alterations in miRNA pathways may provide a new strategy to control infection caused by drug-resistant parasites.
Article
Biochemistry & Molecular Biology
Martha Paluschinski, Sven Loosen, Claus Kordes, Verena Keitel, Anne Kuebart, Timo Brandenburger, David Schoeler, Marianne Wammers, Ulf P. Neumann, Tom Luedde, Mirco Castoldi
Summary: Liver diseases require reliable biomarkers for early detection, prognosis, and therapeutic monitoring. Extracellular vesicles (EVs) have emerged as promising candidates for liver disease biomarkers due to their unique cargo composition, stability, and accessibility in various biological fluids. This study presents an optimized workflow for identifying EVs-based biomarkers in liver disease, including EVs isolation, characterization, cargo analysis, and biomarker validation. It was found that specific microRNAs and cytokines differed in EVs isolated from patients with different liver diseases. Implementation of this workflow can enhance liver disease diagnosis, prognosis, and personalized treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Pirom Noisumdaeng, Thaneeya Roytrakul, Jarunee Prasertsopon, Phisanu Pooruk, Hatairat Lerdsamran, Susan Assanasen, Rungrueng Kitphati, Prasert Auewarakul, Pilaipan Puthavathana
Summary: This study revealed that H5N1 survivors had higher T cell responses to the virus compared to non-survivors, with NP being a highly conserved target for cross-recognition. Therefore, vaccine development targeting the conserved NP may be a novel strategy for influenza vaccine design.
Article
Gastroenterology & Hepatology
Kazumichi Abe, Rei Suzuki, Masashi Fujita, Manabu Hayashi, Atsushi Takahashi, Hiromasa Ohira
Summary: This study identified EV-miR-557 in serum as a potential biomarker for autoimmune hepatitis (AIH) and demonstrated its association with diagnostic and relapse markers. The findings suggest that EV-miR-557 may have potential as a therapeutic target for AIH.
HEPATOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ebru Cenk, Cornelia Schmutz, Gudrun Pahlke, Anne Oertel, Jessica Kollarova, Hans-Peter Mock, Andrea Matros, Doris Marko
Summary: An anthocyanin-rich diet is believed to protect against chronic inflammation, despite the unclear immunomodulatory role of anthocyanins. The study found that cyanidin-3O-glucoside in blackberry juice can reduce TNF-alpha levels, indicating protective effects, but other fractions from blackberry juice may have pro-inflammatory properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Nima Zouei, Abdolhossein Dalimi, Majid Pirestani, Fatemeh Ghaffarifar
Summary: By analyzing the changes in biomarkers such as miR-146a, BAG-1 gene, IL-6, and IL-10 in a mouse model of cerebral toxoplasmosis, this study found that these indicators can be used to evaluate the efficacy of antiparasitic and antibiotic treatment.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Subbiah Kombiah, Manoj Kumar, Harshad Vinayakrao Murugkar, Shanmugasundaram Nagarajan, Chakradhar Tosh, Dhanapal Senthilkumar, Katherukamem Rajukumar, Semmannan Kalaiyarasu, Siddharth Gautam, Rajendra Singh, Mathesh Karikalan, Anil Kumar Sharma, Vijendra Pal Singh
Summary: The study found that both the H9N2PB2 reassortant H5N1 virus and non-reassortant H5N1 virus led to dysregulation of cytokines in the lungs and brain of BALB/c mice.
MICROBIAL PATHOGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Haifeng Lian, Xiaoying S. Zhong, Ying Xiao, Zhe Sun, Yuanyuan Shen, Kaile Zhao, Xingbin Ma, Yanmin Li, Qiong Niu, Max Liu, Don W. Powell, Chengxia Liu, Qingjie Li
Summary: The study identified a potential link between plasma exosomal miRNAs in patients with ulcerative colitis and cardiac remodeling. Excessive levels of miR-29b in exosomes were found to suppress critical proteins like BDNF in IBD, leading to cardiac impairment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
So-Yeon Park, Da-Seul Kim, Hyun-Mun Kim, Jun-Kyu Lee, Dong-Youn Hwang, Tae-Hyung Kim, Seungkwon You, Dong Keun Han
Summary: Mesenchymal stem cells (MSCs) have been used in clinical studies due to their versatility and low immunogenicity. However, safety issues remain a concern. Recently, extracellular vesicles (EVs) derived from MSCs have been explored as an alternative. EVs are nano-sized particles released by cells and have similar biological functions as their origin cells. They carry bioactive molecules and facilitate tissue regeneration. EVs derived from adipose-derived MSCs (ADMSC) also have neuroprotective and neurogenesis effects. This study aimed to enhance the neural differentiation ability of ADMSC-derived EVs by investigating the neurogenic-differentiation process. The results showed that differentiated EVs (dEVs) obtained from neurogenesis conditioned media increased neurogenic ability by altering microRNA expression and cytokine composition. dEVs promoted neuronal differentiation of neural progenitor cells in vitro, indicating their potential in EV-based therapy for neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hongwei Liang, Zichen Jiao, Weiwei Rong, Shuang Qu, Zhicong Liao, Xinlei Sun, Yao Wei, Quan Zhao, Jun Wang, Yuan Liu, Xi Chen, Tao Wang, Chen-Yu Zhang, Ke Zen
NUCLEIC ACIDS RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Ying Wang, Feifei Huang, Ming Liu, Quan Zhao
Summary: UBE2C is frequently overexpressed in gastric cancer patients, primarily through high expression of UBE2C mRNA, which can inhibit gastric cancer colony formation by suppressing DNA biosynthesis. MicroRNA-300 and an RNA binding protein HuR also play a role in suppressing gastric cancer progression by reducing UBE2C mRNA abundance. Additionally, analysis of genes correlated with UBE2C expression in gastric cancer cell lines identified key genes regulated by UBE2C, contributing to its oncogenic activity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Bing Yao, Tao Gui, Xiangwei Zeng, Yexuan Deng, Zhi Wang, Ying Wang, Dongjun Yang, Qixiang Li, Peipei Xu, Ruifeng Hu, Xinyu Li, Bing Chen, Jin Wang, Ke Zen, Haitao Li, Melissa J. Davis, Marco J. Herold, Hua-Feng Pan, Zhi-Wei Jiang, David C. S. Huang, Ming Liu, Junyi Ju, Quan Zhao
Summary: PRMT1-mediated H4R3me2a recruits SMARCA4, which promotes colorectal cancer progression by enhancing EGFR signaling.
Article
Biochemistry & Molecular Biology
Tao Gui, Ming Liu, Bing Yao, Haiqin Jiang, Dongjun Yang, Qixiang Li, Xiangwei Zeng, Ying Wang, Jian Cao, Yexuan Deng, Xinyu Li, Peipei Xu, Liqin Zhou, Dake Li, Zhihui Wang, Ke Zen, David C. S. Huang, Bing Chen, Guiping Wan, Quan Zhao
Summary: Endometrial cancer (EC) is the most common gynecological malignancy globally, with limited understanding of its molecular mechanisms and therapeutic options. EZH2 and DNMT3B were found to promote EC cell proliferation, while TCF3 acts as a tumor suppressor epigenetically silenced by EZH2 and DNMT3B. Targeting the EZH2/DNMT3B/TCF3 axis may offer a novel therapeutic strategy for EC treatment.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Xinyu Li, Mengxia Chen, Biru Liu, Peifen Lu, Xiang Lv, Xiang Zhao, Shuaiying Cui, Peipei Xu, Yukio Nakamura, Ryo Kurita, Bing Chen, David C. S. Huang, De-Pei Liu, Ming Liu, Quan Zhao
Summary: This study identified NonO as a novel transcriptional repressor of gamma-globin gene expression in human erythroid cells, through direct binding to the promoter. Depletion of NonO led to significant activation of gamma-globin expression. Further research also revealed a conserved role for NonO during mammalian evolution.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell Biology
Tian Xia, Ming Liu, Quan Zhao, Jian Ouyang, Bing Chen, Peipei Xu
Summary: PRMT5 is upregulated in multiple myeloma, and its inhibition enhances cell pyroptosis, while the expression of CASP1 negatively correlated with PRMT5 can be restored by suppressing PRMT5, promoting cell pyroptosis in MM.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Li Ping Lin, Dan Liu, Jia Cheng Qian, Liang Wu, Quan Zhao, Ren Xiang Tan
Summary: The study investigates the transformation of I3C into antitumor agents LTr1 and DIM in the human body. The research reveals that this transformation is pH-dependent and influenced by gut microbes, and provides a potential drug candidate.
NATIONAL SCIENCE REVIEW
(2022)
Article
Chemistry, Analytical
Yanrong Wen, Jialing Zhao, Hui He, Quan Zhao, Zhen Liu
Summary: The study introduces a new approach for simultaneously detecting multiple signaling proteins in individual living cells with high sensitivity. By applying this method, researchers discovered an imbalance between survival and apoptotic signaling outputs after EGFR pathway inactivation, which contributed to the final fate of the cell.
ANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Yexuan Deng, Sarah T. Diepstraten, Margaret A. Potts, Goeknur Giner, Stephanie Trezise, Ashley P. Ng, Gerry Healey, Serena R. Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J. Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S. Alexander, Jane E. Visvader, Stephen L. Nutt, Andreas Strasser, Benjamin Haley, Quan Zhao, Gemma L. Kelly, Marco J. Herold
Summary: This study successfully models aggressive lymphomas using CRISPR activation technology in a mouse model. It identifies the pro-survival BCL-2 protein A1 as a resistance factor for venetoclax. This CRISPRa model has the potential to mimic diseases and provide insights into resistance mechanisms for targeted therapies.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Ranran Wang, Lulu Wei, Junaid Wazir, Li Li, Shiyu Song, Kai Lin, Wenyuan Pu, Chen Zhao, Zhonglan Su, Quan Zhao, Hongwei Wang
Summary: Curcumin improves adipose atrophy in cancer cachexia by inhibiting the cAMP/PKA/CREB signaling pathway. The study shows that curcumin protects mice with C26 tumors and cachexia from weight loss and adipose atrophy, reducing levels of free fatty acids and increasing triglyceride levels. Curcumin also ameliorates CL316243-induced adipose atrophy and inhibits hormone-mediated PKA and CREB activation.
Article
Pharmacology & Pharmacy
Lulu Wei, Ranran Wang, Kai Lin, Xiaolu Jin, Li Li, Junaid Wazir, Wenyuan Pu, Panpan Lian, Renwei Lu, Shiyu Song, Quan Zhao, Jiabin Li, Hongwei Wang
Summary: This study investigated the impact of creatine supplementation on weight loss and muscle wasting in cancer cachexia, and found that creatine supplementation protected against body weight and muscle loss, improved grip strength, and mitigated mitochondrial dysfunction in cachectic muscle.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xiangwei Zeng, Bing Yao, Jianpeng Liu, Guan-Wen Gong, Ming Liu, Jiahuang Li, Hua-Feng Pan, Qixiang Li, Dongjun Yang, Peifen Lu, Dongliang Wu, Peipei Xu, Bing Chen, Panhai Chen, Ming Zhang, Ke Zen, Jian Jing, David C. S. Huang, Dijun Chen, Zhi-Wei Jiang, Quan Zhao
Summary: This study identifies a specific hotspot mutation (c. 3721C>T) in the SMARCA4 gene in colorectal cancer (CRC) tissues. The mutation enhances SWI/SNF complex ATPase activity and promotes chromatin remodeling, leading to higher-grade tumors and increased progression in CRC. The mutant SMARCA4 also upregulates transcription of EGFR and TNS4 to promote cell proliferation. The study suggests potential therapeutic strategies targeting the SMARCA4(R1157W) mutation in CRC treatment.
NPJ PRECISION ONCOLOGY
(2023)
Review
Oncology
Jiaxuan Xu, Xiaoqing Dong, David C. S. Huang, Peipei Xu, Quan Zhao, Bing Chen
Summary: BCL-2 inhibitors play a critical role in promoting apoptosis in tumor cells, but drug resistance often develops in patients undergoing treatment. We identified crucial gene mutations that can accurately predict clinical responses to BCL-2 inhibitors. Additionally, we reviewed recent progress in using BCL-2 inhibitors to treat solid tumors, including predictive biomarkers and synergistic drug combinations.
Article
Oncology
Peifen Lu, Zenong Yu, Kangning Wang, Yongping Zhai, Bing Chen, Ming Liu, Peipei Xu, Feng Li, Quan Zhao
Summary: This study finds that DDX21 plays a crucial role in colorectal cancer cell proliferation by activating CDK1 expression and enhancing trimethylation of histone H3 on Lys 4 through recruiting WDR5.
Article
Biochemistry & Molecular Biology
Ying Wang, Xinyu Li, Jingru Ge, Ming Liu, Xiaming Pang, Jianpeng Liu, Cheng Luo, Yichen Xu, Quan Zhao
Summary: Inducing fetal hemoglobin is an effective therapeutic strategy for overcoming adult beta-globin gene deficiency in treating beta-hemoglobinopathies. This study identified PRMT1 as a key regulator that can suppress gamma-globin synthesis specifically at the translational level, and this novel mechanism could be targeted by the PRMT1 inhibitor.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)