期刊
CELL HOST & MICROBE
卷 23, 期 2, 页码 169-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2017.12.018
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资金
- National Institute of Health (NIH) [NS080833, AI132387]
- NIH/NIAID [AI072360, AI108710]
- NIH/NIAID (Harvard-wide Antibiotic Resistance Program) [AI083214]
- Swedish Research Council [2014-5667]
- Wenner-Gren Foundation
- Swedish Cancer Society
- NIH [F32GM121005, P30DK034854]
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-435973-2013]
- Ontario Early Researcher Award
- Boston Children's Hospital Intellectual and Developmental Disabilities Research Center [P30HD18655]
- FunGCAT program from the Office of the Director of National Intelligence (ODNI), Intelligence Advanced Research Projects Activity (IARPA), via the Army Research Office (ARO) [W911NF-17-2-0089]
- Burroughs Wellcome Fund
Botulinumneurotoxins (BoNTs), produced by various Clostridium strains, are a family of potent bacterial toxins and potential bioterrorism agents. Here we report that an Enterococcus faecium strain isolated from cow feces carries a BoNT-like toxin, designated BoNT/En. It cleaves both VAMP2 and SNAP-25, proteins that mediate synaptic vesicle exocytosis in neurons, at sites distinct from known BoNT cleavage sites on these two proteins. Comparative genomic analysis determines that the E. faecium strain carrying BoNT/En is a commensal type and that the BoNT/En gene is located within a typical BoNT gene cluster on a 206 kb putatively conjugative plasmid. Although the host species targeted by BoNT/En remains to be determined, these findings establish an extended member of BoNTs and demonstrate the capability of E. faecium, a commensal organism ubiquitous in humans and animals and a leading cause of hospital-acquired multi-drug-resistant (MDR) infections, to horizontally acquire, and possibly disseminate, a unique BoNT gene cluster.
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