期刊
CELL CYCLE
卷 17, 期 9, 页码 1037-1047出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2018.1464851
关键词
Apoptosis; dynein light chain (DLC); Bim; Bmf; intrinsically disordered protein; nanny protein
类别
资金
- Deutsche Forschungsgemeinschaft [DFG-FOR-2036]
The mitochondrial pathway of apoptosis is regulated by the interplay between the members of Bcl-2 family. Within this family, BH3-only proteins are the sensors of apoptotic stimuli and can trigger apoptosis either by inhibiting the anti-apoptotic Bcl-2-family proteins or by directly activating the effectors Bax and Bak. An expanding body of research suggests that a number of non-Bcl-2 proteins can also interact with Bcl-2 proteins and contribute to the decision of cell fate. Dynein light chain (LC8, DYNLL or DLC), a hub protein and a dimerizing engine has been proposed to regulate the pro-apoptotic activity of two BH3-only proteins, Bim and Bmf. Our recent work has provided insight into the mechanisms through which DLC1 (DYNLL1) modulates Bim activity. Here we discuss the present day understanding of Bim-DLC interaction and endeavor to evaluate this interaction in the light of information from studies of DLC with other binding partners.
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