期刊
CELL COMMUNICATION AND SIGNALING
卷 16, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s12964-018-0237-y
关键词
TRIOBP; Hearing loss; Cancer; Actin-binding protein; Actin cytoskeletal organization; Tara
类别
资金
- Chungnam National University
- National Research Foundation of Korea (NRF) - Korea Government (MEST) [NRF-2017R1A6A3A11031556, NRF-2016K1A3A1A08953546, NRF-2015R1A2A2A01003597, NRF-2015R1D1A3A01015694]
TRIO and F-actin-binding protein (TRIOBP) also referred to as Tara, was originally isolated as a cytoskeleton remodeling protein. TRIOBP-1 is important for regulating F-actin filament reorganization. TRIOBP variants are broadly classified as variant-1 or -4 and do not share exons. TRIOBP variant-5 contains all exons. Earlier studies indicated that TRIOBP-4/5 mutation is a pivotal element of autosomal recessive nonsyndromic hearing loss. However, recent studies provide clues that TRIOBP variants are associated with other human diseases including cancer and brain diseases. In this review, recent functional studies focusing on TRIOBP variants and its possible disease models are described.
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