期刊
CELL CALCIUM
卷 72, 期 -, 页码 132-134出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2018.05.005
关键词
SERCA; Excitation contraction coupling/ECC; Long non coding RNA/lncRNA; Calcium/Ca2; Cardiac myocytes
类别
资金
- Research Foundation Flanders (FWO)
- FWO
Loss of SERCA function contributes to reduced contractility, Ca2+ overload and arrhythmias in the diseased heart. A long non-coding RNA (ZFAS1) upregulated in cardiac disease is reported to directly inhibit SERCA function. The implications for cardiac disease and the wider roles of SERCA are discussed.
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