New aspects of glioblastoma multiforme revealed by similarities between neural and glioblastoma stem cells

Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain

(2017) Yoichiro Kawamura et al.   FEBS LETTERS

Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators

(2017) Harry Bulstrode et al.   GENES & DEVELOPMENT

Histone Deacetylase Inhibitors as Anticancer Drugs

(2017) Tomas Eckschlager et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma

(2017) Maria J. Williams et al.   Frontiers in Oncology

Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3

(2017) Maureen M. Sherry-Lynes et al.   PLoS One

Intratumoral Heterogeneity of the Epigenome

(2016) Tali Mazor et al.   CANCER CELL

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

(2016) Baoli Hu et al.   CELL

Editing DNA Methylation in the Mammalian Genome

(2016) X. Shawn Liu et al.   CELL

Epigenetics in Brain Tumors: HDACs Take Center Stage

(2016) Ilker Y. Eyüpoglu et al.   Current Neuropharmacology

Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions

(2016) Sumiyo Morita et al.   NATURE BIOTECHNOLOGY

Epigenetic mechanisms in neurogenesis

(2016) Bing Yao et al.   NATURE REVIEWS NEUROSCIENCE

Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets

(2016) Ryo Sato et al.   STEM CELLS

Epithelial-mesenchymal transition in glioblastoma progression

(2016) YASUO IWADATE   Oncology Letters

Detection of proneural/mesenchymal marker expression in glioblastoma: temporospatial dynamics and association with chromatin-modifying gene expression

(2015) Hideki Murata et al.   JOURNAL OF NEURO-ONCOLOGY

Stem cell signature in glioblastoma: therapeutic development for a moving target

(2015) Ichiro Nakano   JOURNAL OF NEUROSURGERY

miR-130a can predict response to temozolomide in patients with glioblastoma multiforme, independently of O6-methylguanine-DNA methyltransferase

(2015) Huiyuan Chen et al.   Journal of Translational Medicine

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

(2015) Shohei Furutachi et al.   NATURE NEUROSCIENCE

Circulating biomarkers for gliomas

(2015) Manfred Westphal et al.   Nature Reviews Neurology

Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma

(2015) Melissa M. Singh et al.   NEURO-ONCOLOGY

MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells

(2015) Jun Tsuyama et al.   Stem Cell Reports

Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest

(2015) Helena Carén et al.   Stem Cell Reports

Epigenetic dysregulation in glioma

(2014) Yutaka Kondo et al.   CANCER SCIENCE

Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation

(2014) Kotaro Ohnishi et al.   CELL

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

(2014) Mario L. Suvà et al.   CELL

Mechanisms of astrocyte development and their contributions to neurodevelopmental disorders

(2014) Steven A Sloan et al.   CURRENT OPINION IN NEUROBIOLOGY

Isocitrate dehydrogenase 1and2mutations in gliomas

(2014) Magdalena Megova et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Histone deacetylase inhibitors in glioblastoma: pre-clinical and clinical experience

(2014) Pavel Bezecny   MEDICAL ONCOLOGY

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Epigenetic mechanisms regulating differentiation of neural stem/precursor cells

(2014) Aliya Mari D Adefuin et al.   Epigenomics

Concise Review: Dedifferentiation Meets Cancer Development: Proof of Concept for Epigenetic Cancer

(2014) Yosuke Yamada et al.   Stem Cells Translational Medicine

Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

(2013) Sebastian Bender et al.   CANCER CELL

Mechanisms of astrocytogenesis in the mammalian brain

(2013) Masakazu Namihira et al.   CURRENT OPINION IN NEUROBIOLOGY

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte Form and Function in the Developing Central Nervous System

(2013) Lesley S. Chaboub et al.   Seminars in Pediatric Neurology

Dynamics of 5-Hydroxymethylcytosine and Chromatin Marks in Mammalian Neurogenesis

(2013) Maria A. Hahn et al.   Cell Reports

Understanding Neurological Disease Mechanisms in the Era of Epigenetics

(2013) Irfan A. Qureshi et al.   JAMA Neurology

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression

(2012) W. Zhang et al.   NEURO-ONCOLOGY

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

(2011) D Li et al.   CELL DEATH AND DIFFERENTIATION

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells

(2011) Seiji Hitoshi et al.   NATURE NEUROSCIENCE

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Epigenetic aberrations and therapeutic implications in gliomas

(2010) Atsushi Natsume et al.   CANCER SCIENCE

Epigenetic choreographers of neurogenesis in the adult mammalian brain

(2010) Dengke K Ma et al.   NATURE NEUROSCIENCE

Histone variants — ancient wrap artists of the epigenome

(2010) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic control of neural precursor cell fate during development

(2010) Yusuke Hirabayashi et al.   NATURE REVIEWS NEUROSCIENCE

MicroRNA-34a Inhibits Glioblastoma Growth by Targeting Multiple Oncogenes

(2009) Y. Li et al.   CANCER RESEARCH

Targeting DNA Methylation

(2009) J.-P. J. Issa et al.   CLINICAL CANCER RESEARCH

Committed Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells

(2009) Masakazu Namihira et al.   DEVELOPMENTAL CELL

Epigenetics of neurological cancers

(2009) Shaun D Fouse et al.   Future Oncology

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

(2009) Feng Ye et al.   NATURE NEUROSCIENCE

Epigenetic mechanisms in glioblastoma multiforme

(2009) Raman P. Nagarajan et al.   SEMINARS IN CANCER BIOLOGY

Astrocyte Differentiation of Neural Precursor Cells is Enhanced by Retinoic Acid Through a Change in Epigenetic Modification

(2009) Hirotsugu Asano et al.   STEM CELLS

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

(2008) Joachim Silber et al.   BMC Medicine

Epigenetic-Mediated Dysfunction of the Bone Morphogenetic Protein Pathway Inhibits Differentiation of Glioblastoma-Initiating Cells

(2008) Jeongwu Lee et al.   CANCER CELL

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE