Cancer evolution, mutations, and clonal selection in relapse neuroblastoma

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

(2017) Christopher Abbosh et al.   NATURE

Neuroblastoma is composed of two super-enhancer-associated differentiation states

(2017) Tim van Groningen et al.   NATURE GENETICS

Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

(2016) Mathieu Chicard et al.   CLINICAL CANCER RESEARCH

Deep Sequencing Reveals Occurrence of Subclonal ALK Mutations in Neuroblastoma at Diagnosis

(2015) A. Bellini et al.   CLINICAL CANCER RESEARCH

KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia

(2015) K Malinowska-Ozdowy et al.   LEUKEMIA

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

(2015) Thomas F Eleveld et al.   NATURE GENETICS

Mutational dynamics between primary and relapse neuroblastomas

(2015) Alexander Schramm et al.   NATURE GENETICS

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

(2015) E. M. Van Allen et al.   SCIENCE

Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia

(2015) Xiaotu Ma et al.   Nature Communications

Emergence of New ALK Mutations at Relapse of Neuroblastoma

(2014) Gudrun Schleiermacher et al.   JOURNAL OF CLINICAL ONCOLOGY

A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies

(2014) K Althoff et al.   ONCOGENE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

The genetic landscape of high-risk neuroblastoma

(2013) Trevor J Pugh et al.   NATURE GENETICS

Regulation of Stem Cell Plasticity: Mechanisms and Relevance to Tissue Biology and Cancer

(2012) Robert Strauss et al.   MOLECULAR THERAPY

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma

(2012) Mark Sausen et al.   NATURE GENETICS

Microenvironment and Radiation Therapy

(2012) Michio Yoshimura et al.   Biomed Research International

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Copy number defects of G1-Cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis

(2011) Jan J. Molenaar et al.   GENES CHROMOSOMES & CANCER

Exploring the Genomes of Cancer Cells: Progress and Promise

(2011) M. R. Stratton   SCIENCE

Accumulation of Segmental Alterations Determines Progression in Neuroblastoma

(2010) Gudrun Schleiermacher et al.   JOURNAL OF CLINICAL ONCOLOGY

Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers

(2009) K. D. Siegmund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of ALK as a major familial neuroblastoma predisposition gene

(2008) Yaël P. Mossé et al.   NATURE

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

(2008) Isabelle Janoueix-Lerosey et al.   NATURE

Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing

(2008) P. J. Campbell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative lesion sequencing provides insights into tumor evolution

(2008) S. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA