期刊
CELL
卷 174, 期 1, 页码 143-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2018.04.010
关键词
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资金
- Agence National de la Recherche [ANR-08-PCVI-0032]
- Fondation pour la Recherche Medicale [DEI20151234399]
- Integrative Biology of Emerging Infectious Diseases (IBEID) laboratory of excellence [ANR-10-LABX-62]
- VIP European Research Council [310790-VIP]
- Institut Pasteur
- College de France
- Agence Nationale de la Recherche (ANR) [ANR-08-PCVI-0032] Funding Source: Agence Nationale de la Recherche (ANR)
Neisseria meningitidis, a bacterium responsible for meningitis and septicemia, proliferates and eventually fills the lumen of blood capillaries with multicellular aggregates. The impact of this aggregation process and its specific properties are unknown. We first show that aggregative properties are necessary for efficient infection and study their underlying physical mechanisms. Micropipette aspiration and single-cell tracking unravel unique features of an atypical fluidized phase, with single-cell diffusion exceeding that of isolated cells. A quantitative description of the bacterial pair interactions combined with active matter physics-based modeling show that this behavior relies on type IV pili active dynamics that mediate alternating phases of bacteria fast mutual approach, contact, and release. These peculiar fluid properties proved necessary to adjust to the geometry of capillaries upon bacterial proliferation. Intermittent attractive forces thus generate a fluidized phase that allows for efficient colonization of the blood capillary network during infection.
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