Article
Medicine, General & Internal
Joanna Kaminska, Marek Stopinski, Krzysztof Mucha, Michal Pac, Marek Golebiowski, Monika A. Niewczas, Leszek Paczek, Bartosz Foroncewicz
Summary: The study found that serum OPN, OC, and OPG concentrations significantly increased with the progression of renal disease, with a significant positive correlation among these proteins. OPN and OPG were significantly and positively correlated to the coronary calcium score. Serum OPG showed the strongest correlation to GFR decline and an increased risk of death, particularly in patients with CKD3-4 or ESRD.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Robert A. Olek, Emilia Samborowska, Piotr Wisniewski, Pawel Wojtkiewicz, Krystian Wochna, Jacek Zielinski
Summary: This study investigated the effects of 12 weeks of LC supplementation on BMD and bone metabolism in postmenopausal women participating in a resistance training program. The results showed that LC supplementation increased TMAO and SPARC levels in the blood, but did not significantly affect BMD.
NUTRITION & METABOLISM
(2023)
Review
Chemistry, Physical
Dagmara Slota, Karina Pietak, Josef Jampilek, Agnieszka Sobczak-Kupiec
Summary: The conventional intake of drugs and active substances through oral administration often results in unwanted side effects and the need for increased dosage to achieve the desired effect, as the substances also distribute to other tissues. Tissue engineering offers a solution by designing intelligent systems to deliver active substances precisely to the site of disease conversion.
Article
Cardiac & Cardiovascular Systems
Nikolaos P. E. Kadoglou, Dimitrios Kapetanios, Emmanouil Korakas, Georgia Valsami, Nikolaos Tentolouris, Nikolaos Papanas, Vaia Lambadiari, Christos Karkos
Summary: This study investigated the relationship between osteoprotegerin (OPG) and osteopontin (OPN) levels and adverse outcomes after endovascular revascularization in patients with peripheral arterial disease (PAD). Baseline high levels of OPG and OPN were independently associated with the presence of PAD, but their prognostic role in adverse cardiovascular events needs further clarification.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kaori Ikezaki-Amada, Yoichi Miyamoto, Kiyohito Sasa, Atsushi Yamada, Mitsuhiro Kinoshita, Kentaro Yoshimura, Ryota Kawai, Fumiko Yano, Tatsuo Shirota, Ryutaro Kamijo
Summary: Osteocytes can sense microenvironmental stimuli and regulate bone metabolism by modulating bone resorption and bone formation. This study found that extracellular acidification affects osteocyte function by increasing the production of sclerostin and osteoprotegerin and reducing the nuclear localization of HDAC5 in osteocytes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Kohsuke Shirakawa, Motoaki Sano
Summary: Advances in secondary prevention of cardiovascular diseases have greatly improved prognosis, but CVDs remain a leading cause of global mortality, warranting a re-evaluation of cardiovascular risk and optimal therapy. Inflammation, pro-thrombotic factors, and gene mutations have emerged as potential therapeutic targets for CVDs, with recent studies suggesting the possibility of anti-inflammatory therapy. Osteopontin (OPN) has shown dual roles in cardiovascular pathology, with acute increases having protective effects and chronic increases predicting a poor prognosis, highlighting its potential as a therapeutic target.
Review
Endocrinology & Metabolism
Jialiang S. Wang, Courtney M. Mazur, Marc N. Wein
Summary: The skeleton serves as an endocrine organ controlling mineral metabolism and energy homeostasis. Different bone cell types secrete factors that affect multiple target organs, with osteocalcin and sclerostin playing key roles.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zerrin Kutlu, Arzu Bilen, Muhammet Celik, Adem Maman, Mine Gulaboglu, Ayhan Kul, Zeynep Celik, Zekai Halici
Summary: The study aimed to elucidate the relationship between Ang II and Scl in osteoporotic rats, as well as the role of Scl in the antiosteoporotic effect mechanism of angiotensin receptor blockers. Treatment with telmisartan was found to increase bone mineral density and bone-specific alkaline phosphatase mRNA expression, while decreasing the level of Scl in serum and tissue in OVX groups. These results suggest a potential therapeutic target for osteoporosis.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuichi Takashi, Daiji Kawanami
Summary: Bone plays multiple roles in the body, and recent studies have revealed its endocrine function through the secretion of hormones. These bone-derived hormones are involved in glucose metabolism and diabetic complications, and some of them can serve as biomarkers for predicting diabetes and its progression. Understanding the role of bone-derived hormones may offer new insights into the prediction, prevention, and treatment of diabetes and its complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Mathias Haarhaus, Anders Fernstrom, Abdul Rashid Qureshi, Per Magnusson
Summary: Studies have found that in patients with chronic kidney disease (CKD), serum B1x is associated with improved survival, changes in abdominal aortic calcification score, and aortic pulse wave velocity (PWV). Patients with B1x as an indicator have lower bone turnover, suggesting a reduced cardiovascular risk profile.
Article
Medicine, Research & Experimental
R. A. Zubavlenko, S. Belova, V. Yu Ulyanov
Summary: In rats with modeled posttraumatic knee osteoarthrosis, negative changes in subchondral bone metabolism were observed, emphasizing the crucial importance of structural integrity of subchondral bone in improving the results of reconstructive therapy for local cartilage defects.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Mirthe Dekker, Farahnaz Waissi, Max J. M. Silvis, Joelle Bennekom, Arjan H. Schoneveld, Robbert J. de Winter, Ivana Isgum, Nikolas Lessmann, Birgitta K. Velthuis, Gerard Pasterkamp, Arend Mosterd, Leo Timmers, Dominique P. de Kleijn
Summary: This study investigated the association between plasma OPG and its derived EVs with coronary artery calcification, showing that high levels of OPG were associated with VC.
SCIENTIFIC REPORTS
(2021)
Article
Peripheral Vascular Disease
Kang Liu, Yanqiu Yu, Yu Yuan, Xuedan Xu, Wenhui Lei, Rundong Niu, Miaoyan Shen, Lue Zhou, Rong Peng, Qiuhong Wang, Handong Yang, Huan Guo, Yang Ge, Gang Liu, Meian He, Tangchun Wu, Xiaomin Zhang
Summary: The aim of this study was to investigate the associations between serum alkaline phosphatase (ALP) levels and incident cardiovascular disease (CVD), coronary heart disease (CHD), and stroke, as well as their subtypes. The findings showed that higher ALP levels, even within the normal range, were significantly associated with increased risks of CVD in a dose-dependent manner.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Urology & Nephrology
Yan Lin, Liman Mao, Siqi Chen, Canxin Zhou
Summary: This study systematically investigated the role of serum sclerostin in vascular calcification (VC) in chronic kidney disease (CKD). The results showed that serum sclerostin is associated with the presence of VC and increased risk of all-cause mortality among patients with CKD, but with a decreased risk of cardiovascular events.
Article
Cell Biology
Alexander Tacey, Sophie Millar, Tawar Qaradakhi, Cassandra Smith, Alan Hayes, Susan Anderson, Anthony Zulli, Saoirse O'Sullivan, Itamar Levinger
Summary: The study shows that ucOC has no significant effects on endothelial cell function, with no alteration in blood vessel relaxation or changes in cellular signalling markers observed.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Amee M. Buziau, Philip J. Law, Gabriella Blokland, Casper Schalkwijk, Jean Scheijen, Pomme Simons, Carla van der Kallen, Simone Eussen, Pieter C. Dagnelie, Marleen van Greevenbroek, Richard S. Houlston, Anke Wesselius, Molly Went, Coen Stehouwer, Martijn C. G. J. Brouwers
Article
Endocrinology & Metabolism
Pomme I. H. G. Simons, Olivier Valkenburg, Marjo P. H. van de Waarenburg, Marleen M. J. van Greevenbroek, M. Eline Kooi, Jacobus F. A. Jansen, Casper G. Schalkwijk, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers
Summary: Serum SHBG mediates the association between IHL content and type 2 diabetes, with a higher contribution in women.
Article
Nutrition & Dietetics
Elena C. Tore, Amany K. Elshorbagy, Frans C. H. Bakers, Martijn C. G. J. Brouwers, Pieter C. Dagnelie, Simone J. P. M. Eussen, Jacobus F. A. Jansen, M. Eline Kooi, Yvo H. A. M. Kusters, Steven J. R. Meex, Thomas Olsen, Helga Refsum, Kjetil Retterstol, Casper G. Schalkwijk, Coen D. A. Stehouwer, Kathrine J. Vinknes, Marleen M. J. van Greevenbroek
Summary: This study examined the association between plasma sulfur amino acids and different fat depots. The results showed that methionine was associated with liver fat, while total cysteine was associated with overall obesity and central fat deposition.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Medicine, Research & Experimental
Xiaodi Zhang, Jean L. J. M. Scheijen, Coen D. A. Stehouwer, Kristiaan Wouters, Casper G. Schalkwijk
Summary: In this study, we found that the formation of postprandial methylglyoxal (MGO) in plasma and tissues originates from exogenous glucose and the increase in plasma MGO concentration leads to a fast formation of MGO-derived advanced glycation endproducts (AGEs).
Article
Endocrinology & Metabolism
Mathias D. G. Van den Eynde, Alfons J. H. M. Houben, Jean L. J. M. Scheijen, Armand M. A. Linkens, Petra M. Niessen, Nynke Simons, Nordin M. J. Hanssen, Yvo H. A. M. Kusters, Simone J. M. P. Eussen, Toshio Miyata, Coen D. A. Stehouwer, Casper G. Schalkwijk
Summary: This study found that pyridoxamine (PM), a B6 vitamer and dicarbonyl scavenger, can reduce methylglyoxal (MGO), protein-bound N delta-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1). However, PM does not affect insulin sensitivity and vascular function.
DIABETES OBESITY & METABOLISM
(2023)
Article
Peripheral Vascular Disease
M. Piazza, N. M. J. Hanssen, J. L. J. M. Scheijen, M. Vd Waarenburg, B. Caroccia, T. M. Seccia, C. D. A. Stehouwer, G. P. Rossi, C. G. Schalkwijk
Summary: This study investigated the association between serum AT1AA levels and serum MGO and AGE levels in APA patients, and found no significant correlation between these markers. Furthermore, no significant changes were observed in these markers after adrenalectomy in APA patients.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Review
Endocrinology & Metabolism
Casper G. Schalkwijk, Linda Renata Micali, Kristiaan Wouters
Summary: Diabetes is linked to vascular injury and the development of macrovascular complications. Advanced glycation endproducts (AGEs) and the precursor methylglyoxal (MGO) play important roles in connecting diabetes and vascular injury. While most studies have focused on the relationship between AGEs and vascular injury, the effects of MGO on vasculature are less understood. This review explores the mechanisms linking AGEs and MGO to the progression of atherosclerosis. AGEs and MGO are involved in various stages of atherosclerosis, but further research is needed to understand the exact underlying mechanisms. Nonetheless, targeting AGEs and MGO could provide therapeutic strategies for the macrovascular complications of diabetes.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Nutrition & Dietetics
Marlijne C. G. de Graaf, Jean L. J. M. Scheijen, Corinne E. G. M. Spooren, Zlatan Mujagic, Marieke J. Pierik, Edith J. M. Feskens, Daniel Keszthelyi, Casper G. Schalkwijk, Daisy M. A. E. Jonkers
Summary: A Western diet high in dicarbonyls and advanced glycation endproducts (AGEs) may worsen inflammation in inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). This study examined the intake of dicarbonyls and AGEs in the habitual diet of IBD and IBS patients and their association with intestinal inflammation. The results showed that the absolute intake of dicarbonyls and AGEs was higher in IBD and healthy control subjects compared to IBS. However, after adjusting for energy intake, only glyoxal was lower in IBD compared to IBS and healthy controls. No significant association was found between dietary dicarbonyls and AGEs and intestinal inflammation in either patient group. The findings suggest that potential harmful effects of these compounds in the diet of Dutch patients with IBD or IBS may be counteracted by anti-inflammatory components in the food matrix.
Article
Nutrition & Dietetics
Kim Maasen, Simone J. P. M. Eussen, Pieter C. Dagnelie, Coen D. A. Stehouwer, Antoon Opperhuizen, Marleen M. J. van Greevenbroek, Casper G. Schalkwijk
Summary: The intake of dicarbonyls, such as methylglyoxal, glyoxal, and 3-deoxyglucosone, in the diet is associated with improved insulin sensitivity and a lower prevalence of newly diagnosed type 2 diabetes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Inez Trouwborst, Kristiaan Wouters, Johan W. Jocken, Kelly M. Jardon, Anouk Gijbels, Pieter C. Dagnelie, Marleen M. J. van Greevenbroek, Carla J. van Der Kallen, Coen D. A. Stehouwer, Casper G. Schalkwijk, Nathalie Richard, Igor Bendik, Lydia A. Afman, Ellen E. Blaak, Gijs H. Goossens
Summary: This study explored the relationships between adipose tissue and immune cells, gene expression, and inflammatory markers with liver and muscle insulin sensitivity in overweight and obese individuals. The findings revealed that specific immune cell populations and gene expression showed distinct associations with liver and muscle insulin sensitivity.
Article
Clinical Neurology
Frank C. T. J. van der Heide, Anthony Khawaja, Tos T. J. M. Berendschot, Thomas J. Littlejohns, Elzbieta Kuzma, Robert Luben, Praveen Patel, Paul Foster, Geir Bertelsen, Therese von Hanno, Bente Johnsen, Henrik Schirmer, Sara C. L. Reboucas, Leslie Grasset, Cecile Delcourt, Catherine Helmer, Coen D. A. Stehouwer
Summary: This study investigated the association between retinal neurodegeneration and incident all-cause dementia and AD, finding that lower baseline retinal thickness was associated with a higher incidence of both conditions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Endocrinology & Metabolism
Sara B. A. Mokhtar, Frank C. T. van der Heide, Karel A. M. Oyaert, Carla J. H. van der Kallen, Tos T. J. M. Berendschot, Fabio Scarpa, Alessia Colonna, Bastiaan E. de Galan, Marleen M. J. van Greevenbroek, Pieter C. Dagnelie, Casper G. Schalkwijk, Rudy M. M. A. Nuijts, Nicolaas C. Schaper, Abraham A. Kroon, Miranda T. Schram, Carroll A. B. Webers, Coen D. A. Stehouwer
Summary: This study used population-based observational cross-sectional data to assess the associations between glucose metabolism status and measures of glycaemia with corneal nerve fibre measures. The results showed a linear association between adverse glucose metabolism status, higher levels of glycaemic measures, and corneal neurodegeneration. This study provides evidence that hyperglycaemia-associated corneal neurodegeneration is a continuous process that occurs before the onset of type 2 diabetes.
Article
Immunology
Jan Nagenborg, Han Jin, Adele V. Ruder, Lieve Temmerman, Barend Mees, Casper Schalkwijk, Daniel Mueller-Klieser, Thorsten Berg, Pieter Goossens, Marjo M. P. C. Donners, Erik A. L. Biessen
Summary: In this study, the researchers identified STAT5A as an important determinant of macrophage functions and inflammation in the context of human atherosclerosis, highlighting its potential as a therapeutic target for plaque inflammation in human atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Ophthalmology
S. B. A. Mokhtar, F. C. T. van der Heide, K. A. M. Oyaert, C. J. H. van der Kallen, T. T. J. M. Berendschot, F. Scarpa, A. Colonna, B. E. de Galan, M. M. J. van Greevenbroek, C. G. Schalkwijk, R. M. M. A. Nuijts, M. T. Schram, C. A. B. Webers, C. D. A. Stehouwer
ACTA OPHTHALMOLOGICA
(2023)
Article
Pathology
U. Baylan, A. Baidoshvili, S. Simsek, Cg Schalkwijk, Hwm Niessen, Paj Krijnen
Summary: This study reveals increased presence of CML deposition in the heart of patients with epicarditis, suggesting its involvement in vascular disease pathogenesis.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2023)
