期刊
FITOTERAPIA
卷 102, 期 -, 页码 41-48出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2015.01.009
关键词
Amaryllidaceae; Narcissus jonquilla quail; Alkaloids; Jonquailine; Cancer cells; Antiproliferative effects
资金
- Italian Ministry University and Research (MIUR)
- Belgian Brain Tumor Support (BBTS)
- National Cancer Institute [CA186046-01A1]
- Welch Foundation [AI-0045]
- National Science Foundation (NSF) [0946998]
- NMT Presidential Research Fund
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0946998] Funding Source: National Science Foundation
A new alkaloid, belonging to the pretazettine group of Amaryllidaceae alkaloids, was isolated from dried bulbs of Narcissus jonquilla quail and named jonquailine. Its structure, including the absolute configuration, was elucidated using various NMR, ECD and ESI MS techniques. Initial biological evaluation revealed significant antiproliferative effects against glioblastoma, melanoma, uterine sarcoma and non-small-cell lung cancer cells displaying various forms of drug resistance, including resistance to apoptosis and multi-drug resistance. Jonquailine was also found to synergize with paditaxel in its antiproliferative action against drug-resistant lung cancer cells. The results obtained compared with literature data also showed that the hydroxylation at C-8 is an important feature for the anticancer activity but this seems unaffected by the stereochemistry or the acetalization of the lactol. (C) 2015 Elsevier B.V. All rights reserved.
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