Article
Materials Science, Multidisciplinary
Milena Stevanovic, Marija Djosic, Ana Jankovic, Vesna Kojic, Jovica Stojanovic, Svetlana Grujic, Ivana Matic Bujagic, Kyong Yop Rhee, Vesna Miskovic-Stankovic
Summary: This study developed composite coatings based on chitosan using EPD method, and confirmed their bioactivity and biocompatibility through various analytical techniques, while also monitoring the release of gentamicin.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Chemistry, Applied
Sandeep Singh, Gurpreet Singh, Niraj Bala
Summary: In this study, iron oxide particles were combined with hydroxyapatite to produce a coating that enhanced the antimicrobial and bioactive properties of magnesium implants. The composite coating was found to be blood compatible and could potentially be widely utilized in biomedical implant applications.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Chemistry, Physical
Ahmad Saadati, Behnam Nourmohammadi Khiarak, Ayda Asaadi Zahraei, Aida Nourbakhsh, Hurieh Mohammadzadeh
Summary: In this study, magnesium alloys were coated with hydroxyapatite/chitosan using electrophoretic deposition method with different graphene oxide content. It was found that adding 1% graphene oxide and applying 150V potential significantly improved the corrosion resistance of the magnesium alloys. The microstructure of the coatings showed a significant relationship with their corrosion resistance, potentially due to the formation of well dispersed, low porosity, and relatively dense composite coatings.
SURFACES AND INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Qiuhua Yuan, Ziqiang Zhang, Yuan Yang, Youliang Jian, Ruilong Li, Xiaoyi Dai, Wenshan Wu, Junxi Zhong, Chen Chen
Summary: This study prepared dense and uniform composite coatings of Sr-doped HA complexed with chitosan, which showed good biocompatibility and promoted cell proliferation, adhesion, and osteogenic differentiation.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Materials Science, Coatings & Films
Sandeep Singh, Gurpreet Singh, Niraj Bala
Summary: The study fabricated a composite coating of CS-HA-BG-Fe3O4 with bioactivity, high corrosion resistance, and excellent cell proliferation, suitable for biomedical applications.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Polymer Science
Claudio Zanca, Bernardo Patella, Elisa Capuana, Francesco Lopresti, Valerio Brucato, Francesco Carfi Pavia, Vincenzo La Carrubba, Rosalinda Inguanta
Summary: Calcium phosphate/chitosan/collagen composite coating on AISI 304 stainless steel was investigated for its protective behavior and biocompatibility.
Article
Materials Science, Composites
Tugba Mutuk, Mevlut Gurbuz
Summary: In this study, hybrid nano fiber coatings of HaP, CH, and GNS were electrospun onto the surface of GNS and Si3N4 binary powder reinforced hybrid titanium metal composites to improve biofunctionalilty. Tests revealed that HaP showed the best antibacterial properties and pH change among the coated materials.
JOURNAL OF COMPOSITE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Deepak Poddar, Ankita Singh, Pranshu Rao, Sujata Mohanty, Purnima Jain
Summary: Three-dimensional scaffolds have limitations in terms of porosity, mechanical strength, and direct cell-drug contact. However, bisphosphonate drugs have the potential to stimulate osteogenesis. To overcome these limitations, a scaffold architecture was proposed, where the interface of a polycaprolactone scaffold was coated with alendronate-modified hydroxyapatite to allow cell interaction with the bioactive layer. The mechanical strength was provided by the PCL skeleton. The release behavior of alendronate was governed by the hydroxyapatite component, and its presence increased hMSC proliferation and differentiation. The results showed successful release and improved cell adhesion, proliferation, and osteocyte differentiation.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Ji Xu, Yuan He, Yanan Sun, Xiuming Zhang, Yunfeng Yi, Wei Shi, Dongtao Ge
Summary: In this study, a bioactive material hydroxyapatite (HA) was introduced to construct a conductive polypyrrole (PPy)/HA composite, enhancing its bioactivity and osteoinductive capacity. Micron-topological morphology of scattered grid pattern was designed to further enhance the regulation ability of the coatings to the cells. In vitro test results showed that the micropatterned PPy/HA composite coatings exhibited good bioactivity and promoted mineral deposition and cell proliferation and osteogenic differentiation when accompanied by external electrical stimulation (ES).
Article
Materials Science, Multidisciplinary
Hsueh-Chuan Hsu, Shih-Ching Wu, Chien-Yu Lin, Wen-Fu Ho
Summary: Hydroxyapatite/chitosan (HA/CS) composite coatings were prepared on the surface of low-modulus Ti-25Nb-8Sn alloy by hydrothermal treatment to improve the surface bioactivity. The experimental results showed that the HA/CS composite coatings fabricated at various temperatures through hydrothermal treatment exhibited excellent bioactivity.
Article
Chemistry, Physical
Sadaf Mohandesnezhad, Mohamadreza Etminanfar, Soheil Mahdavi, Mir Saman Safavi
Summary: This study successfully produced a polymer-ceramic layered hybrid coating system containing polypyrrole-hydroxyapatite on the surface of 316L stainless steel through modifying the electrolyte and electrodeposition parameters. The results showed that the coating had higher adhesion strength, corrosion resistance, and promoted appropriate bioactivity.
SURFACES AND INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Yuki Shirosaki, Yasuyo Tsukatani, Kohei Okamoto, Satoshi Hayakawa, Akiyoshi Osaka
Summary: In this study, the mechanical stability of chitosan-based drug delivery capsules was improved by crosslinking the chitosan and coating them with hydroxyapatite to control the release rate. The injection method was found to result in the highest drug loading.
Article
Materials Science, Ceramics
Weiwei Han, Li Liu, Benrui Yu, Qingxia Zhu
Summary: Graphene oxide (GO)/hydroxyapatite (HA) composite coatings were successfully prepared on titanium substrates using electrophoretic deposition technology. The coating's microstructure, phase composition, adhesion strength, hydrophilicity, corrosion resistance, bioactivity, antibacterial activity, and biocompatibility were evaluated. The adhesive strength of the coating increased by 76% when the GO content increased from 0 wt% to 12 wt%, and the corrosion rate reached its minimum at (1.493 x 10-3mm/a) with 8 wt% GO. Biomineralization experiments demonstrated the excellent bioactivity of the GO/HA composite coatings. The water contact angle of the composite coatings increased from 20.6 degrees (0 wt% GO) to 38.1 degrees (12 wt% GO). The antibacterial rate of the coating with 5 wt% GO was 96.7%, but decreased to 25% after thermal treatment. In-vitro L929 cell culture experiments confirmed the biocompatibility of the composite coatings with 5 wt% GO.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Inorganic & Nuclear
A. Sasireka, R. Renji, R. Mohan Raj, S. Vignesh, V. Raj, I. M. Ashraf, Mohd Shkir
Summary: This study developed TNT/CS-PPy@Sr-HAP composite coatings using an electrophoretic deposition method and investigated their antimicrobial activity and corrosion behavior. The results showed that the composite coating exhibited significant antimicrobial activity against bacteria and had better corrosion behavior compared to other coatings, suggesting its potential as a material for orthopedic applications.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Ruquan Ren, Yan Zhong, Xueyong Ren, Yongming Fan
Summary: This article introduces a one-step hydrothermal method to fabricate oxygen-doped activated carbon/graphene composite hydrogels. The composite hydrogels have low cost, high specific surface area, and high conductivity, making them suitable for flexible and wearable energy storage devices. They exhibit excellent energy storage performance and cycling stability.
Article
Materials Science, Multidisciplinary
Bhavana Rikhari, S. Pugal Mani, N. Rajendran
JOURNAL OF MATERIALS SCIENCE
(2020)
Article
Polymer Science
Murugaiyan Manimohan, Sivashanmugam Pugalmani, Mohamed Aboobucker Sithique
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2020)
Article
Polymer Science
Murugaiyan Manimohan, Sivashanmugam Pugalmani, Mohamed Aboobucker Sithique
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2020)
Article
Materials Science, Multidisciplinary
S. Pugal Mani, M. Kalaiarasan, K. Ravichandran, N. Rajendran, Y. Meng
Summary: The single layers of TiN, TiAlN and TiN/TiAlN multilayer coatings were deposited on 316L SS bipolar plate by physical vapor deposition technique. Studies showed that TiN/TiAlN coating exhibited better water management and higher electrochemical impedance behavior in the fuel cell, even meeting the U.S. Department of Energy's 2020 target, and significantly reducing the metal ions dissolution.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
S. Pugal Mani, P. Agilan, M. Kalaiarasan, K. Ravichandran, N. Rajendran, Y. Meng
Summary: This study investigates the deposition of CrN, CrAlN, and CrN/CrAlN coatings on 316L stainless steel to enhance corrosion resistance and reduce interfacial contact resistance in high-temperature proton exchange membrane fuel cells. The results show that CrN/CrAlN coating provides superior protection with a high protective efficiency and lower interfacial contact resistance compared to single CrN and CrAlN coatings.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Metallurgy & Metallurgical Engineering
M. Kalaiyarasan, S. Pugalmani, N. Rajendran
Summary: Biocompatible chitosan and chitosan/silica hybrid coatings were prepared to enhance the biocompatibility and corrosion resistance of biodegradable AZ31 Mg alloy. The optimized coatings showed high corrosion resistance and the chitosan/silica hybrid coating had a small globular rough structure. The presence of functional groups was confirmed by ATR-IR, and the chemical states were examined by XPS studies. The coated samples exhibited a dense layer of coral-like structure and less stoichiometric ratio of calcium-deficient apatite in Earle's solution. In-vitro cell culture studies showed good cell proliferation and the Ch-3/Si coating was non-hemolytic. Bacterial studies demonstrated the inherent antibacterial activity of the Ch-3/Si coating.
JOURNAL OF MAGNESIUM AND ALLOYS
(2023)
Article
Chemistry, Physical
S. Pugal Mani, M. Kalaiyarasan, P. Agilan, K. Ravichandran, N. Rajendran, Y. Meng
Summary: This study focused on the corrosion properties and contact resistance behavior of poly(orthophenlyenediamine) (PoPD) coating on 316L SS bipolar plates. By depositing PoPD coating using an electropolymerization technique with different concentrations of orthophenlyenediamine (oPD), the corrosion rate was reduced and the interfacial conductivity of 316L SS bipolar plates was increased. The analysis and tests showed that the optimized 0.04 M oPD concentration of PoPD coating exhibited the best performance in terms of reducing corrosion current density and providing anodic protection.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Chemistry, Physical
Ramalingam Manikandan, Sankar Sekar, S. Pugal Mani, Sejoon Lee, Deuk Young Kim, S. Saravanan
Summary: The BiW@PEPS electrocatalyst, prepared through hydrothermal and ultrasonication methods, showed excellent electrocatalytic performance of hydrogen evolution reactions (HER) in alkaline conditions due to the synergetic effects of bismuth tungstate with PEDOT: PSS conducting polymer. Compared to pristine bismuth tungstate, BiW@PEPS exhibited enhanced electrocatalytic activity, with a lower overpotential of 361 mV at 10 mA cm-2, small Tafel slope of 106 mV/dec, and enduring stability in 1M KOH electrolyte. The enhanced electrocatalytic performance of BiW@PEPS proves its potential as a beneficial alternative to expensive platinum-based materials in hydrogen production applications.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Infectious Diseases
Varun Prasath Padmanabhan, Pugalmani Sivashanmugam, Ravichandran Kulandaivelu, Suresh Sagadevan, Balu Sridevi, Rajakumar Govindasamy, Muthu Thiruvengadam
Summary: This study evaluated the application of silver nanoparticles combined with biphasic calcium phosphate (BCP) composites in the field of orthopedics. The results showed that the composites had good osteoconductivity and biocompatibility, and exhibited antibacterial activity against various microorganisms.
Article
Chemistry, Applied
Ramalingam Manikandan, S. Pugal Mani, Kumar Sangeetha Selvan, Jang-Hee Yoon, Seung-Cheol Chang
Summary: Screen-printed carbon electrodes were modified with sulfur and oxygen-incorporated graphitic carbon nitride linked poly(1,3,4-thiadiazole-2,5-dithiol) film through thioester linkage. The interaction between the Hg2+ ions and the modified materials containing sulfur and oxygen was studied, and a electrochemical selective sensing of Hg2+ ions was achieved. The modified electrode showed promising results with a concentration range of 0.05-390 nM and a detection limit of 13 pM for Hg2+ ions.
Article
Materials Science, Multidisciplinary
Kalaiyarasan Madhu, Saranya Kannan, Agilan Perumal, Pugalmani Shanmugam
Summary: In this study, a nanocomposite coating of graphene oxide/chitosan/silver nanoparticles (GO/Ag/CS) was electrophoretically deposited on commercially pure titanium (Cp-Ti) to improve corrosion resistance and antibacterial properties. The optimized 10-minute coating exhibited a uniform and agglomerated structure forming a network-like pattern. The potentiodynamic polarization and electrochemical studies confirmed the effectiveness of the nanocomposite coating in reducing corrosion rate and inhibiting bacterial adhesion. Therefore, the application of this nanocomposite coating on Cp-Ti can significantly reduce the possibility of implant failure.
Article
Chemistry, Multidisciplinary
Varun Prasath Padmanabhan, Pugalmani Sivashanmugam, S. M. Mubashera, Suresh Sagadevan, Ravichandran Kulandaivelu
Summary: This study investigated the effects of curcumin-loaded ZnO nanoparticles embedded in graphitic-carbon nitride (g-C3N4) sheets on breast cancer cells. The composite sheets were synthesized using a simple co-precipitation method and their physicochemical and thermal properties were characterized. The results confirmed the successful formation of the composite and its thermal stability. The release of curcumin was found to be more significant under acidic conditions, and the composite exhibited antibacterial and anticancer activities.
Article
Biochemistry & Molecular Biology
Murugaiyan Manimohan, Rajakkani Paulpandiyan, Sivashanmugam Pugalmani, Mohamed Aboobucker Sithique
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Multidisciplinary
Murugaiyan Manimohan, Sivashanmugam Pugalmani, K. Ravichandran, Mohamed Aboobucker Sithique
Article
Chemistry, Multidisciplinary
Manimohan Murugaiyan, S. Pugal Mani, Mohamed Aboobucker Sithique
NEW JOURNAL OF CHEMISTRY
(2019)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
