Article
Chemistry, Applied
Jun Yang, Mingyue Shen, Yu Luo, Ting Wu, Huiliang Wen, Jianhua Xie, Mesona Chinensis
Summary: A novel kind of polyelectrolyte complex hydrogels, MCP-CH, was generated through physical crosslinking, with improved properties and stability as the deacetylation degree (DD) increased, along with enhanced microstructure.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Serap Namli, Ozge Guven, Feyza Nur Simsek, Anton Gradisek, Gulum Sumnu, Meryem Esra Yener, Mecit Oztop
Summary: Chitosan aerogels, obtained by (supercritical) CO2 drying of hydrogels, are novel adsorbents with large surface area and high porosity. The study investigates the combined effects of chitosan's molecular weight and degree of deacetylation on the properties of aerogels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Jonathan Carrasco-Sandoval, Mario Aranda, Karem Henriquez-Aedo, Marcos Fernandez, Amparo Lopez-Rubio, Maria Jose Fabra
Summary: This study aimed to investigate the impact of chitosan's molecular weight and degree of deacetylation on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles. The chitosan coating layer resulted in nanoparticulate systems with good stability, high encapsulation efficiency, and increased bioaccessibility of quercetin after in-vitro digestion. The best results were obtained using low molecular weight chitosan and high degree of deacetylation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Cecilio Carrera, Carlos Bengoechea, Francisco Carrillo, Nuria Calero
Summary: Surface characterization of unmodified chitosan samples with different molecular weights and deacetylation degrees was conducted. The results showed that chitosan exhibited good surface activity at high ionic strength. The concentration of chitosan in the solution and the molecular weight influenced the formation of aggregates, which enhanced adsorption kinetics. Surface rheology revealed a predominantly elastic behavior of chitosan film, indicating its role as a surface-active hydrophilic Pickering agent.
FOOD HYDROCOLLOIDS
(2023)
Article
Polymer Science
Jomarien Garcia-Couce, Miriela Tomas, Gaston Fuentes, Ivo Que, Amisel Almirall, Luis J. Cruz
Summary: This study developed injectable thermosensitive hydrogels for long-term treatment of osteoarthritis. The results showed that the hydrogels exhibited good biocompatibility and controlled drug release properties, indicating their potential as an effective drug delivery platform for osteoarthritis treatment.
Article
Biochemistry & Molecular Biology
Janek Weisspflog, David Vehlow, Martin Mueller, Benjamin Kohn, Ulrich Scheler, Susanne Boye, Simona Schwarz
Summary: Chitosan has attracted interest due to its sufficient charge density under biological, non-hazardous conditions. This work focuses on characterizing important parameters of chitosan, such as solubility, crystallinity, degree of deacetylation, and molecular weight, in a simple and convenient way. Various techniques including NMR, PCD, FTIR, CHN-EA, conductometric/potentiometric titrations, and AF4-LS were used to determine these parameters.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Mousumi Sukul, Priyanka Sahariah, Helene L. Lauzon, Joao Borges, Mar Masson, Joao F. Mano, Havard J. Haugen, Janne E. Reseland
Summary: The DDA and Mw of chitosan sponges affect adhesion, growth, and differentiation of primary human osteoblasts. Higher DDA promotes the secretion of bone growth factors, while lower DDA promotes the secretion of other proteins. The variations in cellular responses to different chitosan sponges suggest potential for individual tailoring of desired responses in guided bone regeneration.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Enci Mei, Cunguo Chen, Chunxiao Li, Xiaoxia Ding, Jiashe Chen, Qiaoer Xi, Sen Zhou, Jingjing Liu, Zhiming Li
Summary: This study developed a local delivery platform using a hydrogel-based approach to co-encapsulate indocyanine green and imiquimod for the treatment of tumors. The combination therapy showed synergistic therapeutic effects by inducing thermal ablation with laser and enhancing immune responses.
Article
Chemistry, Applied
Wentao Wang, Qicheng Zhang, Ming Zhang, Xintong Lv, Zihan Li, Mohsen Mohammadniaei, Ninglin Zhou, Yi Sun
Summary: A novel therapeutic nanocomposite was developed for wound bacterial infections and tumor recurrence, utilizing released reactive oxygen species to kill bacteria and inhibit tumor cell regeneration, as well as utilizing photothermal properties to penetrate the blood tumor barrier for brain tumor treatment. The combination of the nanocomposite with immunotherapy showed potential for improving postoperative therapy and multi-tumor treatments.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Ting Xue, Wenqing Wang, Zhiyuan Yang, Fanjun Wang, Lei Yang, Jian Li, Hui Gan, Ruolan Gu, Zhuona Wu, Guifang Dou, Zhiyun Meng
Summary: This study detected characteristic ions of CS using LC-ESI-MS/MS and analyzed their relationship with CS's DD. The UPLC-MS/MS method was found to accurately determine the DD of CS, unaffected by sample concentration. This study established a highly sensitive, fast, accurate, stable, and durable method for detecting the DD of CS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Asma Sharkawy, Filomena Barreiro, Alirio Rodrigues
Summary: This study investigated the effect of the degree of deacetylation of chitosan on the properties of chitosan/gum Arabic particles and Pickering emulsions. The formulation with higher degree of deacetylation showed higher stability and smaller emulsion droplet size. There was no significant difference in the absorption of cannabidiol between the two formulations.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Multidisciplinary Sciences
Ahmed Mohamed Omer, Basant Yossry Eweida, Tamer Mahmoud Tamer, Hesham M. A. Soliman, Safaa Mohamed Ali, Ahmed Amin Zaatot, Mohamed Samir Mohy-Eldin
Summary: A novel amphiphilic polymer, chitosan grafted citronellal (Ch-Cit) schiff base, was developed for the adsorptive removal of oil spills with high oil adsorption capacity. The chemical structure was verified and optimized using various analysis tools, providing a low-cost oil-adsorbent solution for crude oil spills on sea-water surfaces.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Multidisciplinary
Riwang Li, Yuhui Zhang, Zhen Lin, Qiqi Lei, Yi Liu, Xinyang Li, Mingxian Liu, Gang Wu, Simin Luo, Huajun Wang, Xiaofei Zheng, Lihua Li, Ningjian Ao, Zhengang Zha
Summary: Injectable biocompatible thiolated chitosan (CSSH) hydrogel with pH-response was designed for accurate treatment of tumor cells and tissue reconstruction. Modified halloysite nanotubes (HNTs) improved the mechanical strength of hydrogels and slow the release of doxorubicin (DOX). The drug-loaded gel effectively inhibited tumor growth and recurrence, and repaired defect tissue after tumor resection.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Fei-Chien Chang, Yang Zhou, Matthew Michael James, Hadi M. Zareie, Yoshiki Ando, Jihui Yang, Miqin Zhang
Summary: The degree of deacetylation (DD) of chitosan plays a crucial role in the behavior of human neural stem cells (hNSCs). Films with a higher DD promote hNSC proliferation and maintain multipotency, while films with a lower DD lead to the formation of neural spheroids and a reduction in multipotency protein expression.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Yueliang Zhao, Hongmei Yang, Nana Zhang, Qian Zhou, Daming Fan, Mingfu Wang
Summary: The deacetylation degree of chitosan has a significant impact on heterocyclic aromatic amine formation, with 85% DD chitosan showing the strongest inhibitory effect on PhIP formation. In roast beef patties, the addition of 0.15% (w/w) 85% DD chitosan significantly reduced the formation of various heterocyclic aromatic amines and aldehydes, while potentially promoting fatty acid oxidation. Chitosan addition below 0.15% (w/w) did not have a significant effect on the texture of the roast samples.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Physical
Anisha Anand, Hong-Jyuan Jian, Hao-Hsin Huang, Li Er Hean, Yu-Jia Li, Jui-Yang Lai, Hung-Da Chou, Yu-Chuan Kang, Wei-Chi Wu, Chi-Chun Lai, Chih-Ching Huang, Huan-Tsung Chang
Summary: In this study, anti-angiogenic carbon nanovesicles (CNVs) were synthesized for sustained release of anti-VEGF antibody to treat ocular neovascularization. The CNVs showed good loading efficiency, low cytotoxicity, and strong inhibitory effects on VEGF-induced cell proliferation and migration. In vivo studies demonstrated the superior efficacy of CNVs compared to bevacizumab alone, making them a promising therapeutic agent for age-related macular degeneration.
Article
Chemistry, Physical
Shih-Chun Wei, Amit Nain, Yu-Feng Lin, Ren-Siang Wu, Pavitra Srivastava, Lung Chang, Yu-Fen Huang, Huan-Tsung Chang, Kuan-Ting Chuang, Chih-Ching Huang
Summary: Bacterial infection in chronic wounds can be effectively treated using light-triggered carbon dot liposomes (CDsomes) to accelerate the healing process by targeting the inflammation and proliferation phase.
Article
Engineering, Environmental
Hung-Yun Lin, Ka-Long Luo, Ju-Yi Mao, Chin-Jung Lin, Chen-Yow Wang, Lauren Panny, Shiow-Yi Chen, Shih-Chao Lin, Chih-Ching Huang, Scott G. Harroun, Robert Y. L. Wang, Chang-Jer Wu
Summary: Pandemic of H1N1 infections are frequently reported around the world, and the emergence of drug-resistant strains and limitations of current anti-flu drugs have increased the demand for novel antivirals. In this study, a potent alginate-derived anti-flu material, Alg@AS CNGs, was developed from seaweeds. The Alg@AS CNGs exhibited high biocompatibility and remarkable viral suppression properties against H1N1, surpassing other sulfated polysaccharides. It was found that Alg@AS CNGs could inhibit H1N1 infection by binding to viral particles and lowering oxidative stress in cells.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Ophthalmology
Hsiang-Wen Chien, Chia-Yi Lee, Jing-Yang Huang, Hung-Chi Chen, Kai Wang, Shun-Fa Yang
Summary: This study, using the National Health Insurance Research Database of Taiwan, found a relationship between congenital cytomegalovirus (CMV) infection and late-onset keratitis. Severe congenital CMV infection was found to be significantly correlated with late-onset keratitis in individuals with congenital CMV infection.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Po-Yi Wu, Hung-Chi Chen, Yi-Jen Hsueh, Kuan-Jen Chen, Nan-Kai Wang, Laura Liu, Yen-Po Chen, Yih-Shiou Hwang, Chi-Chun Lai, Wei-Chi Wu
Summary: This study evaluated corneal topography in full-term and preterm children with or without retinopathy of prematurity (ROP). The findings showed that the corneal parameters were higher in preterm children compared to full-term children, and laser-treated preterm children had steeper corneal curvature. The effect of laser treatment and intravitreal injection of anti-vascular endothelial growth factor (VEGF) treatment on corneal topography was minimal.
Article
Biochemistry & Molecular Biology
Chia-Yi Lee, Hsiang-Wen Chien, Jing-Yang Huang, Chieh-Hung Yen, Hung-Chi Chen, Yih-Shiou Hwang, Chao-Kai Chang, Shun-Fa Yang
Summary: Evaluating glaucoma management numbers in patients with both glaucoma and obstructive sleep apnea (OSA) using the NHIRD of Taiwan, it was found that the presence of OSA does not increase the need for glaucoma management.
Review
Health Care Sciences & Services
Po-Yi Wu, Yuan-Kai Fu, Rey-In Lien, Ming-Chou Chiang, Chien-Chung Lee, Hung-Chi Chen, Yi-Jen Hsueh, Kuan-Jen Chen, Nan-Kai Wang, Laura Liu, Yen-Po Chen, Yih-Shiou Hwang, Chi-Chun Lai, Wei-Chi Wu
Summary: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide, involving angiogenesis and cytokine-mediated inflammation. Characteristics and actions of cytokines in ROP pathogenesis are discussed, considering their time-dependent expression and differences between blood and vitreous levels. Animal models of oxygen-induced retinopathy provide valuable data. Less destructive novel therapeutics targeting signaling pathways are needed. Linking ROP-related cytokines to maternal and neonatal diseases can improve ROP management. Modulation of hypoxia-inducible factor, insulin-like growth factor (IGF)-1/IGF-binding protein 3 complex, erythropoietin and its derivatives, polyunsaturated fatty acids, and secretogranin III inhibition are potential treatments for disordered retinal angiogenesis. Emerging therapies such as gut microbiota modulation, non-coding RNAs, and gene therapies show promise for regulating ROP in preterm infants.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Bbumba Patrick, Tahira Akhtar, Rubina Kousar, Chih-Ching Huang, Xing-Guo Li
Summary: Cancer immunotherapy has made significant progress, but it is effective only for a limited number of patients. Carbon nanomaterials have attracted attention due to their unique structure and interaction with the immune system, and they have been explored for their potential in cancer therapy. This article focuses on the latest advances in the immunological effects of carbon nanomaterials and reviews their current preclinical applications. The challenges in fully utilizing the potential of carbon nanomaterials in cancer therapies are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Cheng-Ruei Yang, Yu-Syuan Lin, Ren-Siang Wu, Chin-Jung Lin, Han-Wei Chu, Chih-Ching Huang, Anisha Anand, Binesh Unnikrishnan, Huan-Tsung Chang
Summary: A ratiometric fluorescent probe based on o-phenylenediamine-derived carbonized polymer dots (o-PD CPDs) was developed for real-time intracellular detection of singlet oxygen (1O2). The o-PD CPDs can produce 1O2 and selectively quench the yellow fluorescence, allowing for the selective detection of 1O2 against other reactive oxygen species (ROS). The probe was successfully applied to monitor 1O2 level in the intracellular environment and detect 1O2 and other ROS species in an inflammatory neutrophil cell model.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Girum Getachew, Chien-Hua Hsiao, Aswandi Wibrianto, Akash S. Rasal, Worku Batu Dirersa, Chih-Ching Huang, Neralla Vijayakameswara Rao, Je-Hsin Chen, Jia-Yaw Chang
Summary: The design of therapeutic nanoplatforms based on fluorescent carbon dots (CDs) has become a viable strategy due to their aqueous solubility, biocompatibility, and ease of functionalization. Through doping heteroatoms into CDs structures, N-, Cl-, and S-doped CDs (NClS/CDs) and Se-, N-, and Cl-doped CDs (NClSe/CDs) were synthesized with superior optoelectronic properties. These doped CDs showed enhanced quantum efficiencies and were used for photodynamic therapy (PDT) by efficiently producing reactive oxygen species (ROS) under laser irradiation. Nanovesicles (NVs) loaded with camptothecin (CPT) drug were designed using NClS/CDs, which exhibited ROS-triggered drug release. The study presented an image-guided PDT and chemotherapeutic platform based on the NVs, showing potential for future cancer treatment.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Health Care Sciences & Services
Yi-Jen Hsueh, Yaa-Jyuhn James Meir, Hui-Yi Hsiao, Chao-Min Cheng, Hui-Kang David Ma, Wei-Chi Wu, Hung-Chi Chen
Summary: Understanding the regulatory mechanisms underlying corneal epithelial cell (CEC) proliferation in vitro may provide the means to boost CEC production in cell therapy for ocular disorders. This study aimed to investigate the relationship between Delta Np63 and ATF3 in CECs. The results showed that Delta Np63 increased ATF3 expression and promoter activity, and ATF3 overexpression promoted CEC proliferation through the Delta Np63/ATF3/CDK pathway.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Zi-Rong Chen, Shin-Chieh Chen, Tsung-Yao Wan, Lan-Hsin Chuang, Hung-Chi Chen, Lung-Kun Yeh, Yu-Kai Kuo, Pei-Chang Wu, Yun-Wen Chen, Ing-Chou Lai, Yih-Shiou Hwang, Chun-Fu Liu
Summary: This study aimed to compare the efficacy of atropine 0.125% once every two nights (QON) and once every night (HS) in treating myopia in children. The results showed that the treatment effects of atropine 0.125% HS and QON were similar, suggesting that atropine 0.125% QON may be an alternative strategy for children who cannot tolerate the side effects of atropine 0.125% HS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Snigdha Roy Barman, Shuen-Wen Chan, Fu-Cheng Kao, Hsuan-Yu Ho, Imran Khan, Arnab Pal, Chih-Ching Huang, Zong-Hong Lin
Summary: A next generation of wearable self-powered wound dressing is developed, which can be activated by diverse stimuli from the patient's body and provide on-demand treatment for both normal and infected wounds. The dressing utilizes thermocatalytic bismuth telluride nanoplates (Bi2Te3 NPs) functionalized onto carbon fiber fabric electrodes, generating hydrogen peroxide to effectively inhibit bacterial growth at the wound site. The integrated electrodes connected to a wearable triboelectric nanogenerator (TENG) accelerate wound closure by enhancing cellular proliferation, migration, and angiogenesis. This self-powered dressing has great potential in personalized and user-friendly wound care with improved healing outcomes.
Article
Cell Biology
Hung-Chi Chen, Shun-Fa Yang, Chia-Yi Lee, Yi-Jen Hsueh, Jing-Yang Huang, Chao-Kai Chang
Summary: This study compared the effects of femtosecond laser in situ keratomileusis (FS-LASIK) and laser-assisted lenticule extraction (LALEX) on total antioxidant capacity (TAC) and ascorbic acid (AA). The results showed that LALEX surgery caused a smaller reduction in ascorbic acid, especially in patients with dry eye disease.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Ophthalmology
Yueh-ling Chen, Tsung-ying Tsai, Li-yen Pan, Yueh-ju Tsai, Shin-yi Chen, Ching-hsi Hsiao, Lung-kun Yeh, Hsin-yuan Tan, Hung-chi Chen, Kuo-hsuan Hung, Wuyong Quan, Chun-bing Chen, Wen-hung Chung, David hui-kang Ma
Summary: This study compared the clinical features and visual outcomes in children and adults with SJS/TEN and found that pediatric patients had more severe ocular complications. However, most children were able to maintain good long-term vision. Early intervention and aggressive treatment are crucial for preserving vision.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
