Article
Biochemistry & Molecular Biology
Zhe Liu, Rui Shen, Xingbin Yang, Dehui Lin
Summary: The study investigated the effects of emulsion particle sizes on KGM-based emulsion films. It was found that increasing particle sizes led to smoother films with slightly higher contact angle values, while thermal stability remained unaffected. Physical and mechanical properties of the films were significantly impacted by the particle sizes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Hong Zhuang, Xueqian Li, Sijia Wu, Bing Wang, Haiyang Yan
Summary: The effects of konjac glucomannan (KGM) concentrations on the properties of water-in-oil-in-water emulsion gels were investigated. The addition of KGM improved the stability, rheological properties, and encapsulation efficiency of the emulsion gels. Moreover, KGM delayed the digestion process and enhanced the bioavailability of grape seed proanthocyanidin.
Article
Biochemistry & Molecular Biology
Nitong Bu, Runzhi Sun, Liying Huang, Huanglong Lin, Jie Pang, Lin Wang, Ruojun Mu
Summary: By using emulsion droplets to stabilize cellulose films, it is possible to improve the film's structure and properties, such as surface smoothness, water resistance, UV-shielding performance, mechanical properties, water vapor permeability, antioxidant and antibacterial activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Feng Zhou, Linman Yu, Yang Liu, Zhen Zeng, Cheng Li, Zhengfeng Fang, Bin Hu, Hong Chen, Caixia Wang, Saiyan Chen, Hejun Wu, Wenjuan Wu, Yuntao Liu
Summary: In this study, nanoemulsions of hydroxypropyl-beta-cyclodextrin (HPCD) to lecithin (LEC) at different ratios were prepared and incorporated into a konjac glucomannan/pullulan polysaccharides-based film matrix. The composition and effects of these nanoemulsions on the properties of the composite films were characterized. The results showed that an appropriate HPCD content of 1:1 w/w in the nanoemulsion films restored the mechanical properties and exhibited better structure, retention rate of cinnamon essential oil, antioxidant, and antibacterial activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Wei Xu, Yuli Ning, Yuanyuan Sun, Haomin Sun, Yin Jia, Liwen Chai, Denglin Luo, Bakht Ramin Shah
Summary: The addition of konjac glucomannan (KGM) improved the reversibility of freeze-thaw/re-emulsification in Pickering emulsion stabilized by gliadin/sodium caseinate nanoparticles (Gli/CAS NPs). KGM helped maintain the network structure of the continuous phase, significantly improving the delamination of the emulsion after freeze-thaw treatment. The emulsion with added KGM exhibited good stability and freeze-thaw reversibility, making it promising for long-term storage and re-emulsification.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Chemical
Liling Deng, Yongbo Peng, Yan Li, Geng Zhong, Dan Liu, Zhaojing Zhu
Summary: The chemically modified konjac glucomannan phosphate ester (KGMP) has been developed to overcome the limitations of low solubility, instability, and poor fluidity of konjac glucomannan (KGM). The study investigated the physical, chemical, and rheological properties of KGMP with different degrees of substitution (DS). The results show that KGMP has potential applications in temperature-sensitive matrix materials, gelling food, and water-retaining agents.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Chemistry, Applied
Jingting Xu, Mingxiang He, Cuiping Wei, Mengxia Duan, Shan Yu, Danjie Li, Weiquan Zhong, Cailing Tong, Jie Pang, Chunhua Wu
Summary: TEMPO-oxidized chitin nanocrystal (TOCN) stabilized oregano essential oil (OEO) Pickering emulsions were incorporated into Konjac glucomannan (KGM) matrix to prepare an active food packaging film. The influence of OEO Pickering emulsions on the physical and biological properties of the KGM film was investigated. The results showed that the incorporation of OEO Pickering emulsion improved the barrier properties of the film and enhanced its antioxidant and antimicrobial properties.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Applied
Hyeseung Jeong, Jiseon Lee, Yeon-Ji Jo, Mi-Jung Choi
Summary: Polysaccharide-emulsion gels were prepared using different ratios of methylcellulose (MC) to deacetylated konjac glucomannan (DKG) and two different oils (canola and coconut oil) as animal-fat analogs. These emulsion gels showed thermo-irreversible and thermo-stable properties at 80 degrees C due to the dominant gelling properties of MC. The texture profiles and viscoelasticity of the gels at 20 degrees C were dependent on the DKG:MC ratio and exhibited synergistic effects on gelation.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Applied
Qian Zhang, Sicong Yan, Rong Zhou, Xu Yan, Peineng Zhu, Lingyun Chen, Fatang Jiang
Summary: In this study, a new horizontal casting device and multiple characterization techniques were used to evaluate the compatibility and stability of Konjac glucomannan (KGM) and starch composite systems. The results showed that KGM and starch could form stable dispersions and films with good compatibility at certain ratios. This research provides valuable insights into the interaction mechanism between polysaccharides and starch and offers new perspectives and methods for the development of food design tools.
FOOD HYDROCOLLOIDS
(2024)
Article
Food Science & Technology
Yaqiong Pei, Yanqiu Zhang, Hui Ding, Bin Li, Jun Yang
Summary: The aim of this study was to investigate the physical stability and rheological properties of an oil-in-water emulsion stabilized by a mixture of konjac glucomannan (KGM) and whey protein (WP). Results showed that increasing the concentrations of KGM and WP led to a decrease in droplet size and the formation of a gel-like structure with inverted and resistive flow and stackability. The emulsions exhibited shear thinning behavior and viscoelasticity, with the storage modulus greater than the loss modulus. The findings suggested that the KGM-WP mixture could be used as a substitute for egg yolk in cholesterol-free mayonnaise-like emulsions.
Article
Chemistry, Applied
Liping Guo, Wallace Yokoyama, Ling Chen, Fei Liu, Maoshen Chen, Fang Zhong
Summary: The objective of this research was to identify the structural and physicochemical factors of konjac glucomannan (KGM). The results indicated that hydration rate and viscosity development of KGM solutions were related to particle size and surface morphology, rather than molecular structure. Lower M/G ratios led to lower viscosity, while higher acetyl content exhibited higher viscosity.
FOOD HYDROCOLLOIDS
(2021)
Article
Food Science & Technology
Luhui Wang, Xinru Zhang, Junxia Xiao, Jiayi Shi
Summary: The stability of curcumin-loaded secondary and tertiary emulsions, stabilized by whey protein isolate (WPI) and coated with chitosan (CHI), carboxymethyl konjac glucomannan (CMKGM), or their combination, was investigated. Electrostatic interaction played an important role in the stability of the emulsions, and extra coating with CHI and CMKGM improved the stability and retention of curcumin against environmental stresses. The multilayered emulsions, especially the tertiary emulsion with CMKGM in the outermost layer, could be used as an effective carrier for targeted delivery of curcumin.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biochemistry & Molecular Biology
Ning Liu, Ping Lin, Kun Zhang, Dan Li, Dan Yang, Nishinari Katsuyoshi, Mouming Zhao, Xiaolin Yao
Summary: Konjac glucomannan (KGM) combined with hydroxypropyl methyl cellulose was used to create diacylglycerol oleogels (DGOs) through the emulsion-templated method, and compared with triacylglycerol oleogels (TGOs). The study demonstrated the advantages of using biopolymers as thickening agents for stable emulsion and oleogel formation. The specific characteristics of DGOs, such as earlier transverse relaxation time and slightly lower mechanical strength and oil holding ability compared to TGOs, were attributed to the different properties between the liquid oils.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Liying Huang, Huanglong Lin, Nitong Bu, Jie Pang, Ruojun Mu
Summary: In this research, PVP microfibers incorporated water-in-oil (W/O) emulsions were prepared. The W/O emulsions consisted of hexadecyl konjac glucomannan (HKGM, emulsifier), corn oil (oil phase), and purple corn anthocyanins (PCAs, water phase). The emulsions and microfibers were characterized using CLSM, SEM, FT-IR, Raman, and NMR spectroscopy. The results demonstrated that the addition of PCAs improved the water resistance, mechanical strength, antioxidation, and antibacterial activity of the microfiber films. The microfiber films also exhibited controlled release of PCAs, making them suitable for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Ling Hu, Xiangwei Zhu, Longchen Shang, Yongxin Teng, Jing Li, Bin Li
Summary: This study confirmed for the first time that intrinsic spoilage bacteria are responsible for the decrease in viscosity of KGM hydrosol. The addition of zinc ions is proposed as a new strategy to maintain viscosity for further food applications.
FOOD HYDROCOLLOIDS
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
