Review
Biochemistry & Molecular Biology
Thiecla Katiane Osvaldt Rosales, Joao Paulo Fabi
Summary: Pectin is a polysaccharide that can be used as a coating nanomaterial to form nanostructures for protection, increased absorption, and bioavailability of active compounds. It is easily extracted from natural sources, biodegradable, biocompatible, and non-toxic. Pectin-derived nanoparticles can be added to foods and dietary supplements, opening up broad technological applications as nanocarriers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Food Science & Technology
Pedro Paulo Saldanha Coimbra, Flavio de Souza Neves Cardoso, Edira Castello Branco de Andrade Goncalves
Summary: This study discusses the physicochemical characteristics of wall materials used in encapsulating bioactive compounds for human consumption via spray drying, suggesting that blends of carbohydrate-based and protein-based biopolymers may be the better choice.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Chemistry, Applied
Hamdi Nsairat, Zainab Lafi, Mazen Al-Sulaibi, Lobna Gharaibeh, Walhan Alshaer
Summary: Nanotechnology has significant potential in enhancing the properties and applications of phyto-bioactive compounds (PBCs) in the field of nutraceuticals and food. By encapsulating PBCs into suitable nanocarriers, their solubility and stability can be improved, thus increasing their bioavailability and targeted delivery.
Article
Chemistry, Physical
Shahida Anusha Siddiqui, Nur Alim Bahmid, Ahmed Taha, Abdel-Moneim Eid Abdel-Moneim, Abdelrazeq M. Shehata, Chen Tan, Mohammad Saeed Kharazmi, Yuan Li, Elham Assadpour, Roberto Castro-Munoz, Seid Mahdi Jafari
Summary: This study reviews the application of nanoencapsulation in animal feedings and relevant drugs. Nanoencapsulation design can protect feed bioactives and improve their absorption and release in animals. Chitosan is found to be the most effective carrier. Nanoparticles and nanocapsules are commonly used nanocarriers. Nanofibers, nanohydrogels, and nanoemulsions have not been applied in feeds yet. For ruminants, nano-minerals, vitamins, phytochemicals, essential fatty acids, and drugs are encapsulated using nanoparticles for improved delivery and bioavailability. Safety and regulatory issues, as well as advantages and disadvantages of nanoencapsulation in animal feeds, are also discussed.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Review
Food Science & Technology
Thamila Dib, Haibo Pan, Shiguo Chen
Summary: This review highlights the recent advances in pectin-based nanoencapsulation techniques for the enrichment of bioactive components. The entrapment and release properties of curcumin in pectin-based nanoparticles, as well as the improvement of carrier properties through the addition of natural polymers, are of particular interest.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Food Science & Technology
Yongqiu Cai, Hooi Ren Lim, Kuan Shiong Khoo, Hui-Suan Ng, Yanxue Cai, Jihui Wang, Andy Tak-Yee Chan, Pau Loke Show
Summary: The study examines the challenges of utilizing microalgae bioactive compounds in food applications and explores the application of nanoencapsulation technology to enhance the functionality of microalgae nutraceutical products for improving human health.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Jina Yammine, Adem Gharsallaoui, Alexandre Fadel, Samah Mechmechani, Layal Karam, Ali Ismail, Nour-Eddine Chihib
Summary: Free and nanoencapsulated carvacrol and thymol were found to be effective antimicrobials against Salmonella Enteritidis biofilms on stainless steel. The spherical nanocapsules prepared using the spray-drying technique showed small size and stability, enabling them to disrupt the bacterial membranes and eradicate the biofilms. Furthermore, these antimicrobials showed no toxicity to the environment.
Review
Food Science & Technology
Yongkai Yuan, Mengjie Ma, Ying Xu, Dongfeng Wang
Summary: Biopolymer-based nanoencapsulation shows great potential in delivering functional food ingredients. The pH-driven method has gained attention for its low energy and organic solvent-free characteristics. This review provides an overview of the pH-driven method in biopolymer-based nanoencapsulation, including the protonation reaction and the influence of pH regulators. Different coating materials, particularly proteins, used in pH-driven nanoencapsulation are discussed, along with its application in food. Future development trends focus on the influence of pH regulators on carriers, designing non-protein-based carriers, quantifying driving forces, understanding nutrient absorption mechanisms, and exploring molecular interactions. In conclusion, pH-driven biopolymer-based nanoencapsulation for functional food ingredients has promising prospects.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Applied
Meigui Huang, Yan Sun, Chen Tan
Summary: This review presents the recent advances in utilizing pectin for constructing various emerging nanocarriers. These nanocarriers, including polyelectrolyte nanocomplexes, protein-pectin core-shell nanoparticles, nanoemulsions, nanoliposomes, and nanofibers, can improve the protection, stability, and controlled release of bioactive compounds. The focus is on the applications and challenges for delivering bioactive compounds in the functional food field. This review provides insights into the potential of pectin-derived nano-encapsulating systems for achieving higher bioavailability and health benefits of bioactive compounds.
FOOD HYDROCOLLOIDS
(2023)
Review
Environmental Sciences
Anand Kumar Chaudhari, Vipin Kumar Singh, Akash Kedia, Somenath Das, Nawal Kishore Dubey
Summary: Traditional synthetic pesticides used to control storage insect pests have drawbacks and the search for safer alternatives is urgent. Essential oils and their bioactive compounds have shown promising insecticidal efficacy and favorable safety profiles, but practical application is limited by issues such as volatility, water solubility, and susceptibility to degradation. Nanoencapsulation/nanoemulsion of essential oils is considered a promising tool to overcome these limitations and expand their applicability.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Physical
Aiman Karim, Abdur Rehman, Jianguo Feng, Asia Noreen, Elham Assadpour, Mohammad Saeed Kharazmi, Zhang Lianfu, Seid Mahdi Jafari
Summary: Alginate-based nanocarriers have great potential in the delivery of bioactive compounds. Calcium alginate and sodium alginate, as the most promising wall materials, are non-toxic, relatively cheap, simple to produce, and biocompatible and biodegradable. The review discusses different alginate-based nanocarriers and their entrapment of bioactives, as well as their bioavailability in the gastric environment. Alginate-based nanocarriers can be used as emulsifiers/encapsulants for various bioactives, including vitamins, minerals, peptides, essential oils, and carotenoids. The combination of alginate-based nanocarriers with other polysaccharides/emulsifiers is recognized as the most effective approach for the protection, delivery, and sustained release of bioactives.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Review
Food Science & Technology
Valter F. R. Martins, Manuela E. Pintado, Rui M. S. C. Morais, Alcina M. M. B. Morais
Summary: The encapsulation of bioactive compounds on a micro and nano level has greatly improved industries such as food, nutraceuticals, pharmaceuticals, and agriculture. This technology is used to protect and control the release of various compounds, improving their absorption and targeting them to specific areas in the body. The food industry has utilized nanotechnology to enhance food texture, flavor, nutrient availability, and shelf life. Encapsulating high-value compounds from agro-industrial by-products is not only environmentally sustainable, but also economically beneficial for a circular economy.
Article
Pharmacology & Pharmacy
Jina Yammine, Adem Gharsallaoui, Alexandre Fadel, Layal Karam, Ali Ismail, Nour-Eddine Chihib
Summary: Chemical disinfectants and mechanical methods are commonly used in the food industry to disinfect food contact surfaces. A new strategy involving the use of nanocapsules containing carvacrol and thymol has shown promising potential in replacing these conventional methods. The nanocapsules demonstrated controlled release of the active compounds, resulting in long-term protection against biofilms.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Daniela Cerro, Adrian Rojas, Alejandra Torres, Carolina Villegas, Maria Jose Galotto, Abel Guarda, Julio Romero
Summary: In recent years, there has been a growing interest in the nanoencapsulation of bioactive compounds using Supercritical Fluid Extraction of Emulsions (SFEE) process for the development of nutraceutical products and functional foods. This work provides fundamental information and perspectives on the stages, equipment configurations, and the effect of operational variables on the physicochemical properties of polymeric nanocapsules. The SFEE process offers advantages such as higher encapsulation efficiency, low organic residual solvents, and smaller size, making it suitable for large-scale production of healthier and more bioavailable food products.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Maria A. Azevedo, Miguel A. Cerqueira, Catarina Goncalves, Isabel R. Amado, Lorenzo Pastrana
Summary: The main objective of this study was to encapsulate vitamin D3 (VD3) into nanostructured lipid carriers (NLCs) using rhamnolipids as surfactant. Glycerol monostearate and medium chain triglycerides with 2.625% of VD3 were used as lipid materials. The NLCs + VD3 formulations had sizes ranging from 92.1 to 108.1 nm and showed good stability for 60 days at 4 degrees C. Lower-sized formulations with higher solid lipid content exhibited higher lipolysis rate and VD3 bioaccessibility during in vitro digestion. Rhamnolipids-based NLCs are a promising option for VD3 encapsulation.
Article
Chemistry, Physical
Carla G. Fonseca, Gustavo S. G. de Carvalho, Fernando Wypych, Renata Diniz, Alexandre A. Leitao
APPLIED CLAY SCIENCE
(2016)
Article
Biochemistry & Molecular Biology
Patricia de A. Machado, Jessica O. F. Morais, Gustavo S. G. Carvalho, Wallace P. Lima, Gilson C. Macedo, Elizandra A. Britta, Celso V. Nakamura, Adilson D. da Silva, Alexandre Cuin, Elaine S. Coimbra
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2017)
Article
Materials Science, Multidisciplinary
A. H. Lima, J. P. Mendonca, M. Duarte, F. Stavale, C. Legnani, G. S. G. De Carvalho, I. O. Maciel, F. Sato, B. Fragneaud, W. G. Quirino
ORGANIC ELECTRONICS
(2017)
Article
Agricultural Engineering
Elisa Tatiana Silva Damasceno, Regiamara Ribeiro Almeida, Stephanne Yonara Barbosa de Carvalho, Gustavo Senra Goncalves de Carvalho, Valdir Mano, Arnaldo Cesar Pereira, Luiz Gustavo de Lima Guimaraes
INDUSTRIAL CROPS AND PRODUCTS
(2018)
Article
Chemistry, Organic
Walysson Ferreira de Paiva, Ingredy Bastos Braga, Joao Vitor de Assi, Sandra Milena Bonilla Castaneda, Angel Gabriel Sathicq, Valeria Palermo, Gustavo Pablo Romanelli, Ricardo Natalino, Marcio Jose da Silva, Felipe Terra Martins, Gustavo Senra Goncalves de Carvalho, Giovanni Wilson Amarante, Sergio Antonio Fernandes
Article
Chemistry, Inorganic & Nuclear
Leona S. Flores, Roselia Ives Rosa, Dayara F. Assis, Gustavo Senra G. de Carvalho, Klaus Krambrock, Renata Diniz, Charlane C. Correa
Article
Chemistry, Applied
Alisson Silva Granato, Gustavo S. Goncalves de Carvalho, Carla G. Fonseca, Javier Adrio, Alexandre A. Leita, Giovanni Wilson Amarante
Summary: A series of mixed oxides-supported niobium-based catalysts have been successfully synthesized and applied for the oxidation reactions of benzylamine derivatives, showing enhanced selectivity towards oximes as the main products. Even alpha-substituted benzylamines yielded good isolated yields of oximes under optimized reaction conditions.
Article
Chemistry, Analytical
Rafael Marques, Nerilson M. Lima, Luiz Felipe Cantarino, Gustavo S. G. de Carvalho, Alexandre A. Leitao, Claudimir Lucio do Lago, Marcone A. L. de Oliveira
Summary: This study prepared monolithic stationary phases for capillary chromatography by polymerizing MPTMS monomer, applied them in separating PAHs, and attempted to improve the stationary phase by incorporating BM as a comonomer. The physical homogeneity of the columns was evaluated using an optical microscope and a conductivity detector, while the chemical characterization was done using solid-state NMR spectroscopy.
MICROCHEMICAL JOURNAL
(2021)
Article
Materials Science, Paper & Wood
Amanda Maria Claro, Nayara Cavichiolli Do Amaral, Vitoria Maria Medalha Colturato, Nadia Andrade Aleixo, Robert Paiva, Sandra Andrea Cruz, Gustavo Claro Monteiro, Gustavo Senra Goncalves De Carvalho, Flavia Aparecida Resende Nogueira, Elenice Deffune, Monica Rosas da Costa Iemma, Hernane da Silva Barud
Summary: This study functionalized bacterial cellulose (BC) membranes to improve cell adhesion. The results showed that the MPTMS modification on BC surface was efficient regardless of the drying process. Cell adhesion to the BC surface depends on both the functional group in the matrix and the surface wettability.
Article
Materials Science, Ceramics
Amanda Maria Claro, Caroline Cassia Alves, Kelvin Sousa dos Santos, Euzane Gomes da Rocha, Marina de Lima Fontes, Gustavo Claro Monteiro, Gustavo Senra Goncalves de Carvalho, Jose Mauricio Almeida Caiut, Andrei Moroz, Sidney Jose Lima Ribeiro, Hernane S. Barud
Summary: Tissue engineering is a multidisciplinary field that aims to improve health and quality of life by restoring tissue and organ functions. Cells and scaffolds are the major components of tissue engineering, and 3D porous scaffolds are more suitable for tissue regeneration. In this study, a regenerated cellulose sponge was used as a sacrificial template to synthesize a three-dimensional porous alumina-silica scaffold.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Gustavo Senra Gonsalves de Carvalho, Marcelo Magno de Siqueira, Maria Patricia do Nascimento, Marcone Augusto Leal de Oliveira, Giovanni Wilson Amarante
Review
Chemistry, Physical
Gustavo Senra Goncalves De Carvalho, Alisson Silva Granato, Pedro Possa De Castro, Giovanni Wilson Amarante
CURRENT ORGANOCATALYSIS
(2020)
Article
Chemistry, Multidisciplinary
Gustavo Senra Goncalves De Carvalho, Luciano Honorato Chagas, Carla Grijo Fonseca, Pedro Possa de Castro, Antonio Carlos Sant'Ana, Alexandre Amaral Leitao, Giovanni Wilson Amarante
NEW JOURNAL OF CHEMISTRY
(2019)
Article
Chemistry, Analytical
Lucas Vinicius de Faria, Thalles Pedrosa Lisboa, Rafael Arromba de Sousa, Gustavo Senra Goncalves de Carvalho, Maria Auxiliadora Costa Matos, Renato Camargo Matos
ANALYTICAL METHODS
(2018)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
