期刊
CARBOHYDRATE POLYMERS
卷 195, 期 -, 页码 601-612出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.05.003
关键词
Marine polysaccharide; Metabolic syndrome; Gut microbiota; SCFA; Signal pathway
资金
- National Natural Science Foundation of China [31670811]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Qingdao National Laboratory for Marine Science and Technology [2016ASKJ08-2]
- Taishan scholar project special funds
- Major Science and Technology Projects in Shandong Province [2015ZDJS04002]
Marine polysaccharides (MPs), including plant, animal, and microbial-derived polysaccharides, can alleviate metabolic syndrome (MetS) by different regulation mechanisms. MPs and their derivatives can attenuate MetS by vary cellular signal pathways, such as peroxisome proliferator-activated receptor, 5' adenosine monophosphate-activated protein kinase, and CCAAT/enhancer binding protein-alpha. Also, most of MPs cannot be degraded by human innate enzymes, but they can be degraded and fermented by human gut microbiota. The final metabolic products of these polysaccharides are usually short-chain fatty acids (SCFAs), which can change the gut microbiota ecology by altering the existing percentage of special microorganisms. In addition, the SCFAs and changed gut microbiota can regulate enteroendocrine hormone secretion, blood glucose, lipid metabolism levels, and other MetS symptoms. Here, we summarize the up-to-date findings on the effects of MPs, particularly marine microbial-derived polysaccharides, and their metabolites on attenuating MetS.
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