Article
Biochemistry & Molecular Biology
Jiaxing Huang, Jingyue Guo, Yunsheng Dong, Hui Xiao, Pinyi Yang, Yufei Liu, Sunan Liu, Shuhan Cheng, Jianwei Song, Yuchen Su, Shufang Wang
Summary: In this study, a hyaluronic acid-coated liposome (HALP) nanocomplexes targeting renal epithelial cells was developed to relieve acute kidney injury (AKI). HALP demonstrated higher antioxidant, anti-inflammatory, and anti-apoptotic capacities compared to liposomes (LP) in vitro. HALP not only targeted and accumulated in the injured kidney, but also effectively reduced the inflammatory response, decreased tubular necrosis, and restored kidney function in the AKI model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Jiachuan Xiong, Li Ran, Yingguo Zhu, Yaqin Wang, Shaobo Wang, Yue Wang, Qigang Lan, Wenhao Han, Yong Liu, Yinghui Huang, Ting He, Yan Li, Li Liu, Jinghong Zhao, Ke Yang
Summary: The study reveals the important role of the DUSP2-STAT1 axis in regulating RTEC pyroptosis in AKI and highlights it as an attractive therapeutic target for AKI.
Article
Biochemistry & Molecular Biology
Yinyin Ye, Lingling Xu, Hao Ding, Xiao Wang, Jing Luo, Yu Zhang, Ke Zen, Yi Fang, Chunsun Dai, Yuwei Wang, Yang Zhou, Lei Jiang, Junwei Yang
Summary: PKM2 plays a role in fibroblast activation in AKI, and its loss impairs fibroblast proliferation, promotes tubular epithelial cell death, and may worsen AKI by blocking HGF signal activation. Targeting PKM2 expression could be a novel strategy for treating AKI.
Article
Multidisciplinary Sciences
Xinyi Cao, Jiuchen Wang, Tianye Zhang, Zhiheng Liu, Lijun Liu, Ying Chen, Zehua Li, Youlu Zhao, Qi Yu, Tong Liu, Jing Nie, Yuanjie Niu, Yupeng Chen, Li Yang, Lirong Zhang
Summary: Renal tubular epithelial cells can respond to varying kidney injuries either adaptively or maladaptively. This study elucidates the chromatin-mediated mechanism underlying the responses of renal tubular epithelial cells to different kidney injuries, and identifies RXR alpha as a therapeutic target for acute kidney injury.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Zhenzhen Li, Shan Lu, Xiaobing Li
Summary: Acute kidney injury (AKI) is a common clinical syndrome that can lead to chronic kidney disease (CKD). Damage to renal tubules is a key factor in AKI progression, and metabolic reprogramming plays a crucial role in the development of AKI.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yan Li, Ke Li, Weihao Zhao, Haodong Wang, Xiaodong Xue, Xianghui Chen, Wantao Li, Peihao Xu, Kexin Wang, Pengfei Liu, Xuefei Tian, Rongguo Fu
Summary: This study found that valproic acid (VPA) prevents cisplatin-induced renal injury through regulating glutathione peroxidase 4 (GPX4) and inhibiting ferroptosis. This suggests that inhibiting ferroptosis through VPA is a viable treatment for cisplatin-induced acute kidney injury.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Wei-Cheng Tseng, Pei-Ying Lee, Ming-Tsun Tsai, Fu-Pang Chang, Nien-Jung Chen, Chiang-Ting Chien, Shih-Chieh Hung, Der-Cherng Tarng
Summary: This study demonstrates that the enhancing effect of MSCs, especially HMSCs, on tissue autophagy can be applied to suppress renal tubular apoptosis and attenuate renal impairment during renal I/R injury in rats. These findings provide further mechanistic support for HMSC therapy and its investigation in clinical trials of ischemic AKI.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Pharmacology & Pharmacy
Jialu Li, Chao Yu, Fengchen Shen, Binbin Cui, Na Liu, Shougang Zhuang
Summary: This study found that the inhibition of class IIa HDACs can improve renal function and reduce tubular cell injury and apoptosis in acute kidney injury (AKI), while promoting cellular autophagy and renal tubular cell proliferation. It also targets multiple signaling pathways associated with AKI pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhi-Wei Huang, Yannan Shi, Yuan-Yuan Zhai, Chu-Chu Du, Jiaoyuan Zhai, Run-Jie Yu, Longfa Kou, Jian Xiao, Ying-Zheng Zhao, Qing Yao
Summary: Acute kidney injury (AKI) is a common pathological process associated with high morbidity and mortality worldwide. Bilirubin, with its antioxidant, anti-inflammatory, and anti-apoptotic properties, shows promise as a therapeutic candidate for AKI. Nanotechnology-mediated therapy, particularly using hyaluronic acid-coated epsilon-polylysine-bilirubin conjugate nanoparticles (nHA/PLBR), has shown potential for targeted delivery and enhanced efficacy in protecting against renal injury induced by oxidative stress and inflammation in AKI.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Qisheng Lin, Shu Li, Haijiao Jin, Hong Cai, Xuying Zhu, Yuanting Yang, Jingkui Wu, Chaojun Qi, Xinghua Shao, Jialin Li, Kaiqi Zhang, Wenyan Zhou, Minfang Zhang, Jiayi Cheng, Leyi Gu, Shan Mou, Zhaohui Ni
Summary: This study investigated the mechanism by which mitophagy protects against ferroptosis in cisplatin-induced acute kidney injury. The results showed aggravated iron accumulation, lipid peroxidation, and ferroptosis in mice lacking BNIP3, Pink1, or Park2. Additionally, the synthetic antioxidant ferroptosis inhibitor, Ferrstatin-1, rescued the effects of mitophagy inhibition.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Medicine, General & Internal
Anna Faivre, Thomas Verissimo, Hannah Auwerx, David Legouis, Sophie de Seigneux
Summary: Acute and chronic kidney disease result in significant healthcare costs worldwide. Kidney metabolism undergoes profound changes during injury, potentially affecting fibrosis progression. Glucose metabolism may play a crucial role in both acute and chronic phases of renal disease.
FRONTIERS IN MEDICINE
(2021)
Article
Urology & Nephrology
Lirui Wang, Jiangtao Li, Chen Yu
Summary: The study indicated that SENP3 played a significant regulatory role in LPS-induced AKI, inducing cell apoptosis through protein deSUMOylation and exacerbating damage to renal tubular epithelial cells.
Article
Physiology
Ping Jia, Sujuan Xu, Xiaoyan Wang, Xiaoli Wu, Ting Ren, Zhouping Zou, Qi Zeng, Bo Shen, Xiaoqiang Ding
Summary: This study provides a mechanistic insight into how C-C motif chemokine ligand 2 (CCL2) is upregulated in renal tubular epithelial cells (TECs) and contributes to kidney dysfunction during sepsis. The data reveal that lipopolysaccharide induces CCL2 expression through the Toll-like receptor 2/NF-KB signaling pathway in TECs. Endogenous CCL2 released from TECs, not from myeloid cells, is responsible for sepsis-induced kidney inflammation and acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Liping Deng, Mengqing Xiao, Anshan Wu, Dong He, Sanqian Huang, Tanggang Deng, Jiawei Xiao, Xinyu Chen, Yongbo Peng, Ke Cao
Summary: This study investigates the role of selenium nanoparticles in alleviating cisplatin-induced acute kidney injury. The results suggest that selenium nanoparticles can reduce renal damage by inhibiting ferroptosis, and our self-developed Se/Albumin nanoparticles show superior therapeutic effects compared to regular selenium nanoparticles.
ACS APPLIED NANO MATERIALS
(2022)
Review
Transplantation
Eleni Stamellou, Katja Leuchtle, Marcus J. Moeller
Summary: Acute tubular injury is the most common intrinsic cause of acute kidney injury, and tubular cells can exhibit a rapid capacity for regeneration and repair upon injury. The scattered tubular cell (STC) phenotype represents a uniform reaction triggered by injury, characterized by increased robustness and proliferation during tubular damage.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)